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Biomedical subjects

R C George

Publications and source records attributed to R C George.

97 records · Page 6Linked to original sources
PubMedDate not supplied

Septicaemia caused by an Enterobacter cloacae strain varying in resistance against cephalosporins.

Enterobacter cloacae, sensitive to third-generation cephalosporins (cefotaxime and ceftazidime), was isolated from the stoma of a patient with leukaemia. One month later, he developed a fatal septicaemia, caused by an identical strain isolated from blood cultures. He had been treated with several antibacterial agents, including cefotaxime. The blood culture strain seemed to be a mixture of four variants with different resistance patterns to cefotaxime and ceftazidime. One variant was extremely sensitive to third-generation cephalosporins, one was completely resistant, and two showed variations in zone diameter within sensitivity group 2, both for cefotaxime and ceftazidime. Minimal inhibitory concentration (MIC) studies also showed different resistance patterns between the four variants. Similar variants were found when the stoma isolate was further investigated.

Adult↗
PubMedDate not supplied

Thermospray liquid chromatographic-mass spectrometric analysis of castanospermine-related alkaloids in Castanospermum australe.

Crude sample solution prepared from the seeds of Castanosperum australe was fractionated by preparative liquid chromatography. The fractions thus obtained were subsequently analyzed by means of thermospray liquid chromatography-mass spectrometry (tsp lc-ms). Under the conditions employed, castanospermine [1], 6-epi-castanospermine [2], australine [3], 3,8-di-epi-alexine [4], and fagomine [5] could be separated and detected. The possible structures of other castanospermine-related alkaloids found in the crude sample solution are also discussed.

Alkaloids↗