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Biomedical subjects

R C Feneley

Publications and source records attributed to R C Feneley.

72 records · Page 4Linked to original sources
PubMed1979

The results of prostatectomy: a symptomatic and urodynamic analysis of 152 patients.

There were 152 patients with prostatism investigated by inflow cystometry and pressure flow analysis of micturition before and after elective prostatectomy. Many symptoms attributed to obstruction were found to be owing to bladder instability, which was demonstrated in 60 per cent of the patients. The symptomatic improvement postoperatively was accompanied by a decrease in the incidence of instability to 25 per cent. The repeat urodynamic studies and symptom analysis demonstrated a surgical success rate of 88 per cent.

Aged↗
PubMed1979

Urinary incontinence: prevalence and needs.

The prevalence of recognised urinary incontinence in a community was found to be 1%; the prevalence of unrecognised incontinence was 3.3% in men and 8% in women in a group practice of 7000 patients. The approach to investigation and management of urinary incontinence in a urodynamic unit and the staffing of this unit are described.

Adolescent↗
PubMed1979

The influence of prostatic anatomy on the differing results of prostatectomy according to the surgical approach.

An anatomical study of cadaver prostates has demonstrated that, in all cases, adenomatous tissue lies inferior to the verumontanum. The proportion of tissue distal to the verumontanum varies from less than 10 to 50%. In a series of 100 patients the post-operative urodynamic studies showed that in the tansurethral resection group the mean urethral length was longer, the flow rate lower and the residual urine higher than in the retropubic prostatectomy group. It is suggested that prostatectomy by the transurethral route is less complete due to residual sub-verumontanal prostatic tissue. However, it is likely that by restricting resection to supra-verumontanal tissue many patients are spared post-operative stress incontinence.

Aged↗
PubMed1978

Transfer of adoptive immunity by intra-arterial injection of tumor-immune pig lymph node cells: treatment of recurrent urinary bladder carcinoma after radical radiotherapy.

Twenty-four patients with invasive transitional cell carcinoma of the urinary bladder, recurrent after radiotherapy, were treated by intra-arterial infusion of tumor-immune pig lymph node cells. In 11 patients there was a remission of the disease process, and 3 patients remain alive and free of disease in excess of one year after treatment.

Aged↗
PubMed1978

Adoptive immunotherapy and radiotherapy in the treatment of urinary bladder cancer.

Thirty-one patients with invasive transitional cell carcinoma of the urinary bladder were treated either by infusion of tumour immune pig mesenteric lymph node cells into the tumour blood supply, followed 6 weeks later by 5500 rad, or by radiotherapy alone. The patients were paired prior to treatment, using 4 criteria: age (nearest decade), sex, clinical stage (T3 or T4) and histological grade (average or high). The first patient in each pair then received combined treatment and the second radiotherapy alone. Administration of pig cells before radiotherapy offered no advantage to the patient in terms of the incidence of remission or the length of survival after treatment.

Animals↗
PubMed1978

Idiopathic bladder instability treated by biofeedback.

Biofeedback training has been used to treat 27 female patients suffering from symptoms associated with detrusor instability Re-education to auditory and visual stimuli took place during 4 to 8 one-hour sessions at weekly intervals. Using subjective and objective methods of assessment 81% of the patients were improved following treatment.

Adolescent↗
PubMed1977

Renography as a prognostic index of urinary tract problems in childhood.

Many radiological methods are used in investigating urinary tract problems in children, and some are poorly tolerated. The simplest and most acceptable technique is isotope renography. Its value has been assessed in predicting the outcome of urinary tract problems in 91 children over the age of 2 years presenting consecutively over a period of 3 months. The results of initial assessment by renography and radiography have been compared with the final clinical assessment 7 years later. 35 patients were identified as being "at risk" and all of these had abnormal renograms and radiograms. Normal renographys was found unexpectedly in some patients with severe reflux but with a good final result. It is concluded that renography can be used to screen children with urinary tract infection, thereby excluding the less acceptable radiological investigations unless the renogram is abnormal.

Child, Preschool↗
PubMed1976

Excretion urography in the investigation of prostatism.

The excretion urogram and urodynamic studies of 201 patients presenting with prostatism were reviewed. The urographic features of trabeculation and diverticula were found to be associated with bladder instability as shown on inflow cystometry but not to be associated with outflow obstruction as shown by the pressure-flow analysis of micturition. The bladder shadow on the preliminary film and the bladder size on the post-evacuation film were associated with the measured residual urine and with outflow obstruction. The basal prostatic filling defect was also associated with outflow obstruction.

Aged↗
PubMed1975

The actions of prostaglandins on the smooth muscle of the human urinary tract in vitro.

14 experiments, 10 on bladder muscle strips and 4 on samples of ureteric muscle, were performed to examine the actions of 4 prostaglandins (PGE, PGE2, PGF1alpha and PGF2alpha) on these tissues. Each of the prostaglandins caused bladder muscle to contract and prostaglandin F2alpha was the most potent in this respect. The F series prostaglandins also caused increased ureteric muscle contraction whilst those of the E series inhibited contractions. It is unlikely that contraction is produced by the direct action of prostaglandins on urinary smooth muscle. The suggestion is made that prostaglandins may have a function in the maintenance of vesical tone.

Acetylcholine↗
PubMed1973

Metabolic effects of oestrogen treatment in patients with carcinoma of prostate: a comparison of stilboestrol and conjugated equine oestrogens.

Serum cholesterol and triglyceride levels were estimated and oral glucose tolerance tests performed on 16 patients with carcinoma of the prostate before treatment and while receiving stilboestrol in doses of 1 mg, 7.5 mg, and 15 mg daily and conjugated equine oestrogens (Premarin) 15 mg daily. Serum triglyceride levels were greater than 170 mg/100 ml in nearly all the patients while receiving Premarin or stilboestrol 7.5 mg and 15 mg daily. In six out of 10 patients who were given stilboestrol 1 mg daily the serum triglycerides remained within the normal range. No significant effects on serum cholesterol levels or glucose tolerance tests were observed with the various oestrogen regimens. The results support previous suggestions that a daily dose of 1 mg of stilboestrol should be regularly used in the treatment of carcinoma of the prostate.

Aged↗