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Biomedical subjects

R C Deka

Publications and source records attributed to R C Deka.

35 records · Page 2Linked to original sources
PubMed1980

Effects of prestimulatory carbogen inhalation on noise-induced temporary threshold shifts in humans and chinchilla.

Human subjects and chinchilla breathed either Carbogen or compressed air prior to high level sound stimulation. Following stimulation, threshold shifts and recovery to prestimulation thresholds were monitored. Behavioral audiometry was used for human subjects and electrocochleography was utilized to measure noise-induced threshold shifts in the animals. Results were similar for both human and animal subjects in that preinhalation of Carbogen (05 percent 02 and 5 percent CO2) was seen to decrease the amount of temporary threshold shift (TTS) and to increase recovery rate. Further, histologic study of a limited sample of the experimental animals suggested a notable reduction in the amount of sensory cell damage in subjects that breathed Carbogen before sound stimulation. To follow up on this encouraging indication, an additional experiment was conducted to investigate any differences between Carbogen-treated and non-Carbogen-treated animals with respect to histologically observable high level noise exposure damage. The follow-up experiment resulted in strong evidence that Carbogen inhalation prior to intense sound stimulation decreases the susceptibility to hair cell damage. Carbogen-treated chinchilla sustained cochlear sensory cell damage ranging between 1.1 percent and 1.5 percent, whereas non-Carbogen-treated, noise-exposed chinchilla were found to have between 1.6 percent and 4.6 percent sensory cell damage. The use of Carbogen in prophylactic treatment for unavoidable or accidental noise exposure is discussed.

Acoustic Stimulation↗
PubMed1978

Intestinal absorption of fluoride preparations.

Gastric intestinal absorption of five different preparations of sodium fluoride was measured by means of ten hour urinary excretion. Best absorption was by nonenteric coated sodium fluoride. All three enteric coated preparations showed poorer absorption, with marked individual variations. Florical, the currently available preparation, showed better absorption than any enteric coated tablets and only slightly less than sodium fluoride alone. For active cochlear otospongiosis two capsules three times a day should be prescribed.

Administration, Oral↗
PubMedDate not supplied

Rhinosporidiosis: a study that resolves etiologic controversies.

We have been able to isolate the cyanobacterium Microcystis aeruginosa from water samples of ponds and river where patients of rhinosporidiosis were bathing. It is likely that this cyanobacterium is the causative agents of this disease. The bluish-green cells of M. aeruginosa also have a colorless small cell stage called nanocyte which has been detected in clear waters of all the pond and river samples studied. Both large cells and nanocytes of M. aeruginosa could be recognized inside the round bodies of rhinosporidiosis by light and electron microscopy. Further work on culturing this organism from excised samples and evaluation for drug therapy are in progress. It is hoped that, if therapy becomes available, no surgery would be required for this disease. It is suggested that the waters from ponds and lakes, as well as municipal and recreational waters, be checked for the nanocyte stage of M. aeruginosa. Etiological controversies of rhinosporidiosis have been reasonably solved. The new findings justify a change in the name "rhinosporidiosis" that had been associated with the fungus Rhinosporidium Seeberi.

Anti-Bacterial Agents↗