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Biomedical subjects

R C Collins

Publications and source records attributed to R C Collins.

At least 109 records · Page 6Linked to original sources
PubMed1974

Implant chemotherapy of experimental filariasis.

The in vitro diffusion of the organophosphate famphur from polydimethylsiloxane (PDS) capsules into plasma and their effects on Litomosoides carinii and Dipetalonema witei in jirds was studied. The in vitro rate of diffusion per 24 hours was constant and was directly proportional to the capsule lumen surface area and inversely proportional to the capsule wall thickness. One capsule implanted subcutaneously into each jird almost completely eliminated the microfilaremia of L. carinii while in situ (5 weeks) but had no effect on the levels of microfilaremia of D. witei. The adults of both species were unaffected. The capsules were well tolerated by the jirds and little tissue response to them was noted. The possibilities of using PDS-incapsulated drugs for prophylactic chemotherapy of canine and human filariasis is discussed.

Animals↗
PubMed1970

Energy and epilepsy.

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Adenosine Triphosphate↗
PubMedDate not supplied

Adverse reactions after community treatment of onchocerciasis with ivermectin in Guatemala.

Male and female residents on a Guatemalan coffee plantation where Onchocerca volvulus infections were hyperendemic were offered oral ivermectin (100-200 micrograms/kg) as part of a community-wide treatment programme for onchocerciasis. Forty-five persons were treated and then questioned daily for 28 d about changes in their health. Those with complaints were monitored until all signs and symptoms had resolved. Sixty-seven percent complained of some adverse event after treatment; 60% developed observable adverse reactions attributed clinically to ivermectin. No reaction was life-threatening; the most common were oedema (53%) and fever (47%). Expulsion of intestinal helminths was reported by 38%. Almost all reactions began 24-48 h after treatment; their mean duration was 5 d, despite treatment with acetaminophen and antihistamines. Three patients had oedematous changes lasting over 2 weeks. Incidence, but not severity, of reactions was related to the pretreatment density of microfilariae in skin.

Adolescent↗