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Biomedical subjects

R C Chen

Publications and source records attributed to R C Chen.

At least 109 records · Page 6Linked to original sources
PubMed1976

Parameters of spikes in human epilepsy.

The parameters of 600 spikes were studied in 100 epileptic patients. Spikes were subdivided morphologically into: monophasic spikes, diphasic spikes, spike-slow wave complexes, polyspike-slow wave complexes and spike followed by spike. The following parameters were analyzed: polarity, amplitude, duration and sequence, 88% of spikes were negative. 98% of spikes raised 30% above the background activity. Spike duration varied, the shortest spike had a 9 msec duration. The range of duration varied from 9 to 200 msec with a mean of 45.06. 75% of spikes were followed by a deflection lasting from 130 to 200 msec. No evidence was found in our study for the differentiation of sharp waves from spikes.

Adult↗
PubMed1975

Effects of ketamine in epilepsy.

Ketamine, a rapid-acting general anesthetic, was administered intravenously to 26 epileptics. The effects of ketamine on the patients' clinical seizures and electroencephalograms were compared with similar periods during alert and sleep states. Epileptic discharges were present in the alert electroencephalogram of 17 (65 percent) of the patients. Epileptic discharges were precipitated or aggravated by sleep in 15 patients (58 percent) and by ketamine in eight patients (31 percent). No siezures were recorded during ketamine anesthesia. Ketamine neither precipitates nor aggravates seizures and is less effective than natural sleep as an activator of epileptic discharges.

Adolescent↗