Search PubMed⌕ Search

Biomedical subjects

R C Bennett

Publications and source records attributed to R C Bennett.

At least 73 records · Page 4Linked to original sources
PubMed1983

Multiple or sequential oestrogen receptor assays in breast cancer.

Multiple oestrogen receptor assays have been performed on primary, locally recurrent, and metastatic breast cancer in 62 patients. A change in receptor status was found in seven of 25 late recurrences (28%). It was noted that the level of oestrogen receptor was higher in lymph nodes than the primary tumour, particularly at the time of initial surgery. Other factors which might contribute to differences in receptor levels include site of metastases, method of handling, heterogeneity of tumours, and subsequent treatment. Such differences have important implications in management.

Antineoplastic Agents↗
PubMed1982

Tennessee antigen: the predictive value of preoperative and postoperative assays in large-bowel cancer.

Twenty-nine of 31 patients bearing resectable colorectal cancers had elevated levels of serum Tennessee antigen in comparison with only eight of 31 patients for carcinoembryonic antigen. This high detection rate is, however, of limited value since the level of serum Tennessee antigen is not specific for the presence of malignancy. There appeared to be no relationship between the level of preoperative serum Tennessee antigen and subsequent prognosis. Furthermore, in only nine of 31 patients did the serum Tennessee antigen level fall after removal of all macroscopic cancer. There also appeared to be no relationship between the level of serum TennaGen at three months after resection and subsequent prognosis. These findings are in contrast to estimations of serum carcinoembryonic antigen.

Antigens, Neoplasm↗
PubMed1982

Tennessee antigen: its value in the monitoring of patients with colorectal cancer.

Serial estimations of serum Tennessee antigen have been performed at regular three-month intervals on 35 patients with colorectal cancer who had undergone resection of all macroscopically obvious tumor but who were considered to be at high risk of developing subsequent metastases. The results were interpreted by a panel of surgeons in order to assess the clinical relevance of using serum Tennessee antigen for monitoring of patients. The serial estimation of serum Tennessee antigen was found to be very variable, difficult to interpret, and clinically unreliable as an accurate marker for the development of recurrent cancer in this group of patients. There are unacceptably high false-positive and false-negative diagnostic rates for serum Tennessee antigen estimations in comparison with serial estimations of carcinoembryonic antigen.

Antigens, Neoplasm↗
PubMed1982

Incidence and toxicological aspects of drugs detected in 484 fatally injured drivers and pedestrians in Ontario.

Results are presented of a comprehensive drug study carried out on specimens from drivers and pedestrians fatally injured in Ontario. Toxicological analyses were regularly performed on blood and urine and occasionally on vitreous humor, stomach contents, and liver. The analytical procedures could detect and quantitate a wide variety of drugs including such illicit drugs as Cannabis. With respect to drivers, alcohol was found in 57% of the study sample and drugs other than alcohol, in 26%. However, in only 9.5% of the drivers were psychoactive drugs (other than alcohol) detected in the blood in concentrations that may adversely affect driving skills. Delta-9-Tetrahydrocannabinol and diazepam accounted for a majority of the findings in this category.

Accidents, Traffic↗
PubMed1980

The histopathology of microlymphaticovenous anastomosis.

Histopathological studies are described on 30 biopsy specimens of lymphaticovenous anastomoses ranging from two days to eight months following operation. Sixteen were patent and 14 were occluded. It was observed that in the non-patent specimens occlusion stemmed from the venous component. The prime determining factor in the success of the anastomosis was the achievement of correct apposition of the cut edges of the vessels, and this was directly dependent on the number and spacing of the sutures as well as the tension applied at their insertion. Correct apposition is more easily achieved with these delicate thin-walled vessels by better visualization afforded by the use of the operating microscope and appropriate instrumentation. The slow rate of repair in this situation is emphasized.

Animals↗
PubMed1979

The fate of choline in the circulating plasma of the rat.

Labelled free choline injected into the peritoneum failed to enter the brain but preferentially entered the liver. Subsequently labelled phospholipid was found in the plasma with a concurrent increase in the brain. This labelled plasma injected by cardiac puncture caused a rapid incorporation of the choline labelled phospholipid into the brain.

Animals↗
PubMed1979

Omental transposition and skin graft in the management of chest wall recurrence of carcinoma of the breast.

The greater omentum is readily available for the reconstruction of the defect produced after palliative excision of recurrent breast carcinoma. It covers a wide area and readily accepts a skin graft, and it has been observed that there is some local immunity to the reappearance of further recurrence at the site of the graft. The operation can be combined with endocrine ablation.

Aged↗
PubMed1977

The monitoring of serum factors in patients with cancer.

Numerous changes occur in the sera of patients bearing malignant neoplasms. These changes may take the form of appearance of oncofetal proteins that are normally not detectable in non-cancer-bearing patients, or an alteration in the normally present serum constituents such as the serum proteins. Monitoring of these serum factors may be of considerable value in assessing the progress of cancer patients following treatment of their primary tumour. This paper reviews progress in this area to date and documents our early results with six non-specific serum factors (total protein, total protein hexose, total protein hexosamine, ceruloplasmin, alpha-1-antitrypsin, and haptoglobin), in 64 patients bearing a variety of malignant neoplasms in various stages of the disease. Present methods of postoperative assessment of cancer patients are inadequate for detecting early recurrence. Preliminary results indicate that the nonspecific serum factors that we are studying may be of considerable value for monitoring of cancer patients, and may also possibly serve as a diagnostic screen in high-risk groups.

Antigens, Neoplasm↗
PubMed1976

Women's attitudes to mastectomy for breast cancer.

One hundred patients who had been subjected to mastectomy for carcinoma were interviewed retrospectively to gauge their attitudes to any physical and/or emotional disabilities relating to their operation or disease. It was found that 40% of the patients had delayed for longer than a month after the onset of symptoms before seeking medical advice, but the reasons for this were not readily forthcoming. However, fear of mastectomy was not a common cause. Anxiety and embarassment due to an absent breast occurred in about one-third of patients, and did not diminish with time. Knowledge and the use of mammary prostheses was far from universal, and disturbingly only two-thirds were counselled in these matters by their medical advisers. Physical complications were common, particularly lymphoedema of the arm, and as expected this was closely related to the type and extent of treatment undertaken.

Adult↗
PubMed1976

Presence of type III collagen in guinea-pig dermal scar.

Guinea-pig dermal scar was shown to contain type III collagen, and, from densitometric analysis of gel electrophoretograms, it was shown to have a higher concentration than the surrounding dermis. This finding is consistent with the 'embryonic' nature of newly formed dermal wound tissue, reflected in increased hydroxylation of collagen lysine and the presence of dihydroxylysinonorleucine (after reduction) as the major cross-link.

Animals↗
PubMed1976

Bilateral carcinoma of the breast.

A review of patients treated at the Peter MacCallum Clinic, Melbourne, between 1968 and 1973 inclusive, revealed 76 cases of primary carcinoma involving the opposite breast. Twenty-one of these occurred synchronously, when they were usually associated with elderly patients, a strong family history and an increased delay in presentation. The behaviour of these tumours was unremarkable, though the survival of the patients may have been less than those with single lesions, and in accord with the doubled risk of distant spread and local recurrence. Fifty-five patients with metachronous lesions did not present initally with features which would help to identify them as being prone to this double pathology. About 50% of the second carcinomas occurred within five years, but the remainder developed at intervals which were in several cases longer than 20 years. The patients did not present earlier on the second occasion, and several had advanced lesions. There was no evidence that the behaviour of the second carcinoma was influenced by immunological factors or patient susceptibility. Implications with regard to management are outlined, and the importance of long-term follow-up with regular examination is emphasized.

Adult↗
PubMed1975

Major abdominal bleeding in chronic pancreatitis.

This case report concerns a patient with chronic pancreatitis which led to extensive retroperitoneal haemorrhage from a rupture of the abdominal aorta. The rarity of this complication is emphasized, but other reported instances of bleeding in association with chronic pancreatitis are commented upon.

Aorta, Abdominal↗
PubMed1975

Measurement of the immune response to an allograft: amino acid incorporation by peripheral white blood cells in man.

The uptake in vitro of 3H-thymidine and of 3H-uridine by white blood cells freshly taken from the recipients of renal transplants has been followed at regular intervals during the period of the patients' hospitalization. In addition, groups of subjects without renal failure undergoing operation and of patients on chronic dialysis have been studied. Of 33 patients undergoing rejection of their kidney, 28 showed a marked rise in the incorporation of thymidine over the period of rejection. However, a similar rise appears to accompany episodes of inter-current infection.

Graft Rejection↗