We studied the effect of high cholesterol fat breakfast containing approximately 527 mg cholesterol and 33 gm fat given for seven days in 10 healthy females of young age (18 to 21 years) and in healthy older females of age group (48 to 60 years). Serum total cholesterol and low density lipoprotein did not alter significantly after feeding and after withdrawal of high cholesterol fat breakfast. Serum high density lipoprotein increased significantly in young females after feeding and further increased after withdrawal for seven days, while in older females no appreciable change occurred. Serum triglyceride showed a significant decline in young persons after feeding but gradually increased after withdrawal while in older females no significant change occurred.

Adolescent↗

PubMedDate not supplied

A comparative study of three different test diets in change in plasma total cholesterol in young healthy individuals.

The effect of single dose of three different types of high cholesterol diet on plasma total cholesterol (PTC) in 24 young healthy subjects (male:female = 1:1) aged 15 to 35 years was studied. One group (n1 = 8) was given a butter and milk diet (300 mg cholesterol and 95 g fat). In the first postprandial hour PTC level increased significantly in all but one subject (mean +/- S.D., 4.96 +/- 0.57 m mol/l to 5.61 +/- 0.60 m mol/l, P < 0.005). Second group (n2 = 8) was given a single egg diet (300 mg cholesterol and 6 g fat). In the first hour the PTC level decreased significantly in all but 2 subjects (4.82 +/- 0.58 m mol/l to 4.42 +/- 0.63 m mol/l, P < 0.02). Third group subjects (n2(3) = 8) were given a test diet consisting of crystalline cholesterol with 200 ml milk (1020 mg cholesterol and 14 g fat). The PTC level increased insignificantly. In the first hour in all but 2 subjects (4.94 +/- 0.43 m mol/l to 5.35 +/- 0.88 m mol/l, P > 0.10). In the third postprandial hour the PTC values in all the 3 groups showed a tendency to return to fasting values. Therefore, we conclude that the effect of dietary cholesterol on PTC depends not only on the amount of cholesterol content in the diet, but on the type of diet (cholesterol vehicle) as such and probably also on the fat content of the diet.

Adolescent↗

PubMedDate not supplied

A study of short term lipoprotein changes induced by single high cholesterol diet in healthy and diseases human volunteers.

Changes in lipid lipoprotein profile were observed in the first and third hours after feeding 750 mg of egg cholesterol in 13 healthy male subjects (Group A), 6 patients of coronary artery disease (Group B), 10 diabetic patients (Group C), and 10 hypertensive patients (Group D), all belonging to the age group of 35-60 years. 61.53% of healthy male subjects showed a fall in the total serum cholesterol (STC) in the first hour after feeding, while in the rest there was a rise. On the other hand, 66.67% of coronary artery disease patients, 50% of diabetics and 50% hypertensives showed a rise in the first hour while the rest showed either a fall or no change in STC. All groups showed a fall in LDL at the first hour. In the third hour the STC and LDL level increased in group A, C and D, whereas in group B STC showed a fall and LDL showed a rise. All these changes were, however, statistically insignificant. The changes in HDL values were also statistically insignificant except in group D where they showed a progressive rise increase in the first and third hours.

Adult↗

PubMedDate not supplied

Diabetic retinopathy: a clinical study with special reference to fluorescein angiography.

The present study was conducted on 25 patients with Diabetes Mellitus (DM) having positive indication of diabetic retinopathy on ophthalmoscopic examination. The patients were examined clinically, ophthalmoscopically and with Fluorescein Angiography (FA). It was found that the maximum number of patients with retinopathy were in their 5th and 6th decade and that retinopathy was more common in Non Insulin dependent diabetics (NIDDM) than Insulin dependent Diabetics (IDDM). It was also seen that retinopathy takes longer time to develop in IDDM patients (16.37 years vs 11.7 years). Proliferative diabetic retinopathy was more common with patients having poor glycemic control and in IDDM patients. FA was very helpful in detecting microaneurysms and for exact localization of neovascularization, and other microangiopathic lesions as well as for permanent record.

Adult↗

PubMedDate not supplied

A study of high fat and cholesterol induced lipoprotein changes in first degree relatives of patients of myocardial infarction.

The effect of seven days feeding of high cholesterol and high fat breakfast (HCFB) (79.5 g fat, 1655 mg cholesterol) and its withdrawal was studied on 20 first degree relatives of patients of myocardial infarction (Group A) and 18 controls (Group B). All subjects were young (30 years of age) and had no other risk factor for ischaemic heart disease (IHD). At basal level the first degree relatives had significantly lower values for all lipid fractions except that of HDL. In the control group seven days after giving HCFB a significant rise occurred in all lipid fractions except LDL. The rise of HDL was dominant which led to a significant reduction in LDL/HDL ratio. However, in the first degree relatives no significant change could be observed in any lipid fraction. Seven days after the withdrawal of HCFB there was a significant reduction in all lipid fractions in controls but in first degree relatives the cholesterol level increased significantly from its basal value. However, other lipid fractions showed no significant change, and LDL/HDL ratio remained constant throughout. These different types of behavioural responses to cholesterol could be helpful in identifying high risk hereditarily predisposed persons at early age when basal lipid values are inconclusive.

Adult↗

PubMedDate not supplied

Effect of administration and withdrawal of oral contraceptive pills on serum lipids and lipoproteins.

We studied the effects of oral contraceptive pills (OCP) supplied by the Govt of India in its Family Welfare Campaign, on serum lipid levels of women. The OCP, containing 30 micrograms ethinyl estradiol and 1 mg of norethisterone acetate were administered to the women for six months continuously and serum lipid levels were estimated after three and six months of the treatment. There were no significant changes in serum cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), serum triglycerides and very low density lipoprotein (VLDL). In a simultaneous study we also measured serum lipid levels at 3 and 6 months after withdrawal of the pills in women who had been receiving OCP containing 50 micrograms of ethinyl estradiol and 0.5 mg of one of the progesterones for the past 1 1/2 to 2 years continuously. Only serum LDL level fell significantly (P less than 0.01) on 3 months withdrawal period. It is concluded that 6 months of usage of the OCP marketed by the Govt. of India does not affect the serum lipid profile.

Adult↗

PubMedDate not supplied