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Biomedical subjects

R C Arora

Publications and source records attributed to R C Arora.

At least 109 records · Page 6Linked to original sources
PubMed1980

Quantitative relationships between oestradiol-17beta in the milk and blood of lactating buffaloes.

The concentration of oestradiol-17beta was measured by radioimmunoassay in the milk and blood of lactating buffaloes after insemination. The concentration of oestradiol-17beta in milk was observed to be two to three times higher when compared with that in plasma samples. Major peaks of oestradiol-17beta in milk coincided with similar but smaller peaks occurring in plasma samples. In animals which were not pregnant, the major peak of oestradiol-17beta was recorded on the day of oestrus.

Animals↗
PubMed1979

Extrapyramidal side effects and increased serum prolactin following fluoxetine, a new antidepressant.

Fluoxetine (Lilly 110140) is a potent, specific serotonin (5-HT) uptake blocker which is being tested in man for antidepressant activity. One of 9 depressed patients receiving this drug developed a dystonic reaction, parkinsonian rigidity, and increased serum prolactin levels, all signs of decreased dopaminergic activity. Homovanillic acid levels also decreased in the cerebrospinal fluid of this subject. We postulate that fluoxetine, via the increase in 5-HT activity resulting from 5-HT uptake blockade, inhibited both the nigro-striatal and tubero-infundibular dopaminergic neurons. These results provide additional evidence for a linkage between serotonergic and dopaminergic neurons in man.

Adult↗
PubMed1979

Blood and milk progesterone in pregnant and nonpregnant buffalo.

Changes in progesterone concentration of blood and milk were measured by radioimmunoassay in 10 Murrah buffalo up to 40 days after insemination. Progesterone concentration in blood plasma at estrus was .1 ng/ml which rose to a peak of 3.6 ng/ml on day 13. It continued to increase in animals that conceived but dropped to .6 ng/ml on 3 days before next estrus in those that failed to conceive. The average concentration of progesterone in milk was .5 ng/ml at estrus; it increased to 18 ng/ml on day 15, and thereafter it declined to 4.4 ng/ml 3 days preceding next estrus in nonpregnant animals. In pregnant animals, it was maintained and elevated further to 24.8 ng/ml on day 37. Progesterone in milk was four to five times higher than in blood plasma.

Animals↗
PubMed1976

Subsynaptosomal localization and biochemical characterization of serotonin binding sites in the brain.

The subsynaptosomal distribution of the borohydride stabilizable binding of serotonin (5-HT) in the brain was investigated using various enzyme markers, such as NAD glycohydrolase (NADase), Na+, K+-activated ATPase for synaptic membranes, and monoamine oxidase (MAO) for outer mitochondrial membranes. The gross distribution of the activity of NADase and Na+, K+-activated ATPase in various membrane fractions was found to parallel the distribution of 5-HT binding in these fractions. Radioactivity bound to brain fractions was extractable with chloroform-methanol (2:1). The membranous material was solubilized by chloroform-methanol (2:1) and the recovered material, suspended in 0.32 M sucrose was found to retain its 5-HT binding capacity. The protein-phospholipid nature of the binding subcellular macromolecule was demonstrated with proteolytic and lipolytic enzymes.

Adenosine Triphosphatases↗