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Biomedical subjects

R C Anderson

Publications and source records attributed to R C Anderson.

261 records · Page 15Linked to original sources
PubMedDate not supplied

Toxic effects of air freshener emissions.

To evaluate whether emissions of a commercial air freshener produced acute toxic effects in a mammalian species, the authors allowed male Swiss-Webster mice to breathe the emissions of one commercial-brand solid air freshener for 1 h. Sensory irritation and pulmonary irritation were evaluated with the ASTM-E-981 test. A computerized version of this test measured the duration of the break at the end of inspiration and the duration of the pause at the end of expiration--two parameters subject to alteration via respiratory effects of airborne toxins. Measurements of expiratory flow velocity indicated changes in airflow limitation. The authors then subjected mice to a functional observational battery, the purpose of which was to probe for changes in nervous system function. Emissions of this air freshener at several concentrations (including concentrations to which many individuals are actually exposed) caused increases in sensory and pulmonary irritation, decreases in airflow velocity, and abnormalities of behavior measured by the functional observational battery score. The test atmosphere was subjected to gas chromatography/mass spectroscopy, and the authors noted the presence of chemicals with known irritant and neurotoxic properties. The Material Safety Data Sheet for the air freshener indicated that there was a potential for toxic effects in humans. The air freshener used in the study did not diminish the effect of other pollutants tested in combination. The results demonstrated that the air freshener may have actually exacerbated indoor air pollution via addition of toxic chemicals to the atmosphere.

Administration, Inhalation↗
PubMedDate not supplied

Respiratory toxicity in mice exposed to mattress covers.

To evaluate factors that might contribute to the rise in prevalence of childhood asthma, we allowed groups of male Swiss-Webster mice to breath the emissions of six brands of waterproof crib mattress covers for 1 h. We used a computerized version of ASTM-E-981 test method to monitor respiratory frequency, pattern, and airflow velocity. Single exposure to the emissions of these mattress covers caused various combinations of sensory irritation, pulmonary irritation, and decreases in mid-expiratory airflow velocity. At the peak effects of these emissions, sensory irritation ranged from 9% to 51% of the breaths, pulmonary irritation ranged from 4% to 16% of the breaths, and airflow limitation ranged from 9% to 38% of the breaths. Three brands caused airflow limitation that persisted for at least 24 h after a single 1-h exposure of naive mice to these emissions. Repeat exposures to the emissions of four brands caused more marked effects (i.e., up to 96% of the breaths showing sensory irritation, up to 44% of the breaths showing pulmonary irritation, and up to 75% of the breaths showing airflow limitation). Histological evaluation of the lungs revealed a mild inflammatory response, with focal collections of polymorphonuclear leukocytes and edema, but there were no eosinophils and no bronchial mucosa changes. We used gas chromatography/mass spectrometry to evaluate one of the test atmospheres, and there was evidence of chemicals for which toxic properties have been documented previously. The results of our study demonstrated that some mattress covers emit mixtures of chemicals that can cause a variety of acute toxic effects in mice, including asthma-like reactions.

Animals↗
PubMedDate not supplied

Acute respiratory effects of diaper emissions.

Mice were monitored with pneumotachographs while they breathed emissions of three brands of disposable diapers (described herein as brands A, B, and C) and one brand of cloth diapers for 1 hr. The authors used a computerized version of the ASTM-E-981 test method to measure changes in the pattern and frequency of respiration. In response to two brands of disposable diapers, many mice exhibited reduced mid-expiratory airflow velocity, sensory irritation, and pulmonary irritation. During the peak effects, brand A caused sensory irritation in 47% of the breaths and reduced mid-expiratory airflow velocity in 17% of the breaths (n = 39 mice), whereas the respective percentages noted for brand B were 20% and 15% of the breaths (n = 28 mice). The effects were generally larger during repeat exposures to these emissions, with up to 89% of breaths showing sensory irritation in response to brand A and up to 35% of breaths showing reduced mid-expiratory airflow velocity with brand B. A third brand of disposable diapers caused increases in respiratory rate, tidal volume, and mid-expiratory airflow velocity. The emissions of cloth diapers produced only slight SI and slight PI. Chemical analysis of the emissions revealed several chemicals with documented respiratory toxicity. The results demonstrate that some types of disposable diapers emit mixtures of chemicals that are toxic to the respiratory tract. Disposable diapers should be considered as one of the factors that might cause or exacerbate asthmatic conditions.

Acute Disease↗
PubMedDate not supplied

Sensory irritation and multiple chemical sensitivity.

Many of the symptoms described in Sick Building Syndrome (SBS) and multiple chemical sensitivity (MCS) resemble the symptoms known to be elicited by airborne irritant chemicals. Irritation of the eye, nose, and throat is common to SBS, MCS, and sensory irritation (SI). Difficulty of breathing is often seen with SBS, MCS, and pulmonary irritation (PI). We therefore asked the question: can indoor air pollutants cause SI and/or PI? In laboratory testing in which mice breathed the dilute volatile emissions of air fresheners, fabric softeners, colognes, and mattresses for 1 h, we measured various combinations of SI and PI as well as airflow decreases (analogous to asthma attacks). Air samples taken from sites associated with repeated human complaints of poor air quality also caused SI, PI, and airflow limitation (AFL) in the mice. In previous publications, we have documented numerous behavior changes in mice (which we formally studied with a functional observational battery) after exposure to product emissions or complaint site air; neurological complaints are a prominent part of SBS and MCS. All together, these data suggest that many symptoms of SBS and MCS can be described as SI, PI, AFL, and neurotoxicity. All these problems can be caused by airborne irritant chemicals such as those emitted by common commercial products and found in polluted indoor air. With some chemical mixtures (e.g., emissions of some fabric softeners, disposable diapers, and vinyl mattress covers) but not others (e.g., emissions of a solid air freshener), the SI response became larger (2- to 4-fold) when we administered a series of two or three 1-h exposures over a 24-h period. Since with each exposure the intensity of the stimulus was constant yet the magnitude of the response increased, we concluded that there was a change in the sensitivity of the mice to these chemicals. The response was not a generalized stress response because it occurred with only some mixtures of irritants and not others; it is a specific response to certain mixtures of airborne chemicals. This is one of the few times in MCS research that one can actually measure both the intensity of the stimulus and the magnitude of the response and thus be allowed to discuss sensitivity changes. The changing SI response of the mice might serve as a model of how people develop increasing sensitivity to environmental pollutants. Intensive study of this system should teach us much about how people respond to and change sensitivity to airborne irritant chemicals.

Administration, Inhalation↗
PubMedDate not supplied

Histologic and microradiographic evaluation of textured and nontextured aluminum oxide dental implants.

This paper reports the histological and microradiographical observations of macroscopically textured and nontextured aluminum oxide dental implants. Ion beam bombardment was used to produce a wafflelike pattern of surface undulations approximately 35 microns deep. Twelve nontextured and eight textured implants were placed in the healed extraction sites of the second and forth mandibular premolars of adult mongrel dogs. Eight nontextured and five textured implants remained in situ for six months. Results consistent with previously reported clinical and radiographic findings, indicated a decreased incidence of an interposed fibrous tissue-implant interface associated with the textured implants. Texturing was not found to influence the amount of vertical bone loss. Secondarily, delayed tissue fixation due to post-retrieval mechanical testing procedures resulted in loss of valuable cellular information.

Aluminum↗
PubMedDate not supplied

Family health care: with special emphasis on the USA.

Urbanization and specialization has led to fragmentation of health care. Not only has the whole individual hbeen lost sight of, but the family unit has been ignored. Recent attempts to reconstitute primary care or family medicine concepts have often failed because the focus remains primarily upon individual health care. Family health care foxuses upon the family unit as the primary target of health behavior. The family has a "family health estate". As such the family unit is shown to have the capacity to promote health or produce illness among its memebers. A family's health is defined as its capacity to effectively cope with illness events. The family is a mediator of life stress, a defining agency of health and illness events, and a determinant of health care utilization. The physician can fill six roles in family health care: health educator, health counselor, anticipatory guide, recruitor of resources, crisis intervenor and family therapist.

Child↗
PubMedDate not supplied

An evaluation of skeletal attachment to LTI pyrolytic carbon, porous titanium, and carbon-coated porous titanium implants.

Porous titanium, carbon-coated porous titanium, and low-temperature isotropic (LTI) pyrolytic carbon transcortical implants were placed in the femora of mongrel dogs. Mechanical and histologic analyses were performed in specimens that remained in situ for six months. Qualitative histologic results indicated that the bone formed a direct appositional interface with as-deposited LTI carbon. The bone tissue response to the two systems with porous coatings was similar. Both systems showed little fibrous tissue interposition and a high degree of mineralized bone ingrowth. The ingrown bone was well organized. However, there was some evidence that the ingrown bone mineral differed significantly from the bulk bone mineral. The only difference between carbon-coated and uncoated porous systems was a significant increase in the percentage of bone ingrowth, with carbon-coated specimens having a 4% increase in bone volume. The strength of appositional attachment to LTI carbon was shown to be at least one order of magnitude weaker than bone ingrowth attachment to the porous systems. The interface shear stiffness of the two porous systems was equivalent; however, the attachment shear strength of bone growth into carbon-coated porous titanium was significantly increased compared with that of bone growth into the uncoated porous titanium. Correlation of the percentage of bone ingrowth and pushout strength was also found to be statistically significant, suggesting that the presence of the carbon coating enhanced bone ingrowth, which resulted in significantly increased shear strengths.

Animals↗
PubMedDate not supplied

Effect of a commercial competitive exclusion culture (Preempt) on mortality and horizontal transmission of Salmonella gallinarum in broiler chickens.

A commercial competitive exclusion (CE) culture (PREEMPT) was evaluated for its ability to decrease mortality during the first 10-12 days posthatch resulting from the causative agent of fowl typhoid, Salmonella gallinarum. In the first experiment, chicks provided the CE culture on day of hatch and challenged with 10(5) S. gallinarum on day 3 had a significant decrease in mortality compared with non-CE-treated S. gallinarum-challenged chicks in all four replicates. Mortality for control chicks when averaged across all four replicates was 74% compared with 7.5% for the CE-treated chicks. A second experiment was performed that was designed to measure the efficacy of the CE culture in decreasing the horizontal transmission of this pathogen from infected to uninfected chicks when commingled. Day-of-hatch chicks that were directly infected (seeders) with 10(5) S. gallinarum and provided no CE culture averaged 86% S. gallinarum organ positive and 80% mortality during the first 12 days posthatch across four replicates. Untreated contact (not directly infected) chicks that were commingled with the seeder chicks averaged 84% S. gallinarum organ positive and 54% mortality, and the commingled CE-treated contact chicks (provided CE culture on day of hatch) average 35% S. gallinarum organ positive and 9% mortality during the same time period. These results are of importance to the poultry industry in geographic areas where poultry production is adversely affected by fowl typhoid and indicate that treating newly hatched chicks with this commercial CE culture may be a novel way of decreasing economic losses associated with this highly pathogenic organism.

Animals↗