The penetration of cephalosporin antibiotics into bone.
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Biomedical subjects
Publications and source records attributed to R C Anderson.
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The Leopard syndrome, an acronym, consists of the following features: L-lentigines (multiple), E-electrocardiographic abnormalities, O-ocular hypertelorism, P-pulmonary stenosis, A-abnormalities of genitalia, R-retardation of growth and D-deafness (sensorineural). In addition to the lentigines a few large dark café-noir spots may be scattered over the trunk. Electrocardiographic abnormalities include the S1, S2, S3 pattern and frequently there is pulmonary valvular dysplasia characterized by a pulmonary systolic ejection murmur but no ejection click. Some patients have had subaortic or subpulmonic defects. Others have had atrial septal defect. Hypospadias, cryptorchidism or absence of one ovary has been found. The syndrome is inherited as an autosomal dominant trait.
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Kids, 6-28 weeks of age, infected with 200-1000 infective larvae of meningeal worm (Pneumostrongylus tenuis) of white-tailed deer (Odocoileus virginianus), developed colitis and peritonitis. Bacteroides sp., Bacillus sp., Escherichia coli, Proteus sp. and Enterococcus sp. were found in the peritoneal cavity. Most kids were moribund or dead 4-11 days after infection and frequently the colon had ruptured. Only two kids (of 11) in which the disease was allowed to run its course survived colitis and peritonitis but these two animals developed severe neurologic signs 18 and 38 days after infection. Numerous developing worms and various traumatic and other lesions were found in the central nervous system of kids which developed neurologic signs.
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