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Biomedical subjects

R Byck

Publications and source records attributed to R Byck.

45 records · Page 3Linked to original sources

Patienthood.

The experience of being a patient is valuable in learning how to become a humane physician. The behavior of students and house officers is modeled on their attending and senior residents. Interactions with patients will be more likely to resemble the example of senior physicians than any theoretical or ideal example, no matter how well taught.

Medical Staff, Hospital↗

Cocaine and succinylcholine sensitivity: a new caution.

Cocaine was stable (93.6 +/- 5.0 (SD)% remaining after 120 minutes) when incubated in plasma from six patients with histories of succinylcholine sensitivity and low dibucaine numbers (phenotype A), but was rapidly hydrolyzed (40.6 +/- 6.6% remaining after 120 minutes) when incubated in plasma obtained from normal subjects (phenotype U). Intermediate decay (69.4 +/- 9.0% remaining) occurred in three heterozygous offspring of the succinylcholine-sensitive patients. Since serum cholinesterase has recently been implicated in the human metabolism of cocaine, patients who are homozygous for the atypical enzyme may be at greater risk for a toxic reaction when administered this drug. We recommend caution in using cocaine for topical anesthesia in patients with histories of succinylcholine sensitivity or low dibucaine numbers.

Anesthesia, Intravenous↗