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Biomedical subjects

R Bussani

Publications and source records attributed to R Bussani.

99 records · Page 6Linked to original sources

[Basal cell epithelioma of the lip. Analysis of 42 cases].

Basal cell epithelioma of the lip. An analysis of 42 cases. The authors carried out a histopathological and epidemiological study of 42 basal cell epitheliomas of the lip. Both sexes were equally affected (male to female ratio 0.9:1) but the females were significantly older than the males (mean age: 70.7 years vs 62.3 years respectively). The incidence in the province of Trieste was 1.44%... for males and 1.46%... for females. More than 80% of the lesions (35 cases) consisted in solid forms, but there were also 4 cheratotic basal cell epitheliomas, 1 fibrosing epithelioma and 1 basosquamous epithelioma. In 2 of the males there was a recurrence a year after the surgical exeresis and in 6 cases another epithelioma was synchronous or metachronous to the lip epithelioma. Despite the fact that in 3 cases invasion of the muscular wall was noted and in another case the neoplasm had infiltrated and eroded the left nostril and the lower part of the septum, no patient died from the tumour nor were any metastasis observed.

Aged↗

[Squamous carcinoma of the lip. Review of 98 cases].

Squamous lip carcinoma. A review of 98 cases. Ninety-eight new cases of squamous lip carcinoma (87 males and 11 females), diagnosed over a 10 year period at the Institute of Pathological Anatomy of the University of Trieste were studied from an epidemiological point of view and in relation to their biological behaviour. The overall incidence was equal to 6.67%... in males and 0.73%... in females, with a male to female ratio of 9.2:1. The distribution of the cases can be directly correlated to age: the incidence in the 80-84 age group among males was 3 times greater than that in the 60-64 age group and 4 times greater than that in the 55-59 age group. Among females the highest number of cases occurred from 85 years of age upwards. The relative frequency of the carcinoma for each of the 3 epithelial surfaces was 46.9% for skin lesions (46 cases) and 50% (49 cases) for those on the vermilion, while the carcinoma originated in the internal mucosa in just 3 cases. In 11 cases the tumour had originated on the upper lip (8 males and 3 females, male to female ratio 2.6:1) and 6 of these were skin tumours. The relative frequency of skin neoplasms of the lip was 38.8% for 1978-81, 43.3% for 1982-85 and 64% for 1986-87. A study of the age specific incidence showed that the maximum number of cases occurred in the 75-84 age group (8.37%) for vermilion carcinomas and in patients over 85 (7.69%) for skin of lip carcinomas. In 17 patients the tumour was already infiltrating at the first biopsy (13% of skin carcinoma and 23% of carcinomas arising on the mucosa), and in 9 cases there were metastasis to the laterocervical nodes and/or salivary glands. In 14 patients the tumour recurred. From a study of the autopsies on the 27 patients who died it emerged that in 18 cases (66.6%) there was no tumour, nor was there any local infiltration or metastasis, while in 4 cases the tumour was still present and infiltrating the surrounding tissue. In 4 other cases the primary tumour was no longer present but metastasis and/or infiltration had developed. Associations with one or more malignant neoplasms of the oral cavity or the upper aerodigestive tract were noted in 9 cases.

Aged↗

[The temporomandibular joint (TMJ) and osteogenesis imperfecta. A study of its embryologic development].

Although the most common oral manifestation of osteogenesis imperfecta is dentinogenesis imperfecta, several authors have described jaw fractures and radiolucent bone lesions associated with this disease. The authors, after reporting the main features of this disease, compare the cranial embryologic growth in twice fetuses of a 15 weeks old: one of these with osteogenesis imperfecta.

Gestational Age↗

[Occurrence of acute refractory hypotension during laparoscopic cholecystectomy. Report of a case and review of the literature].

The authors report the case of a patient who developed irreversible cardiovascular collapse during a laparoscopic cholecystectomy. The abrupt onset of shock and the rapid deterioration of the hemodynamic conditions prevented a thorough diagnostic workup. Possible differential diagnoses of hypotension occurring during laparoscopic procedures are reviewed and discussed.

Acute Disease↗

[DNA ploidy and cell kinetics in cancer of the rectum].

The pathological assessment of rectal cancer remained essentially unchanged for 50 years and it is based mainly on Dukes' classification and histological granding. Alternative methods of classifications have also been developed but, actually, Dukes'taging is the most important prognostic factor. The limit of Dukes' classification is the incomplete discrimination between high risk and low risk patients into the same stages. The measurements of cellular DNA content by flow cytometry is emerging as a prognostic aid in many human tumours. Authors analyze on the basis of their experience on 116 curative operations for the cancer of the rectum, the relationship between tumour's features, CEA, symptoms, recurrences, survival, type of operation and DNA flow cytometry. In 100 cases they studied the percentage of cells in "s" phase. (SPF). Samples of flow-cytometry were prepared using paraffin-embedded tumour blocks. The authors didn't find any statistically significant relation among pathological features, staging, ploidy and SPF. Recurrences rate was 16.6% in diploid tumours and 23% in no diploid (p = 0.3). In SPF < 25% it was 18.2% (p = 0.5). 5-year survival was worse in aneuploid patients (p = 0.06). Using Cox' multivariate regression analysis, ploidy has not independent prognostic significance. In conclusion authors consider ploidy a prognostic factor in rectal cancer, but not independent. However, authors conclude that flow cytometry could help in early staging of the disease, especially in preoperative diagnosis. Flow cytometry has a prognostic significance with informations on tumoral biology and could contribute to select patients for adjuvant therapy or different surgical techniques.

Adult↗