Sixty-two outpatients were assessed and divided into the following groups: 20 patients who had had partial gastrectomy (PG group), 22 patients who had had truncal vagotomy and pyloroplasty (TV group) or high selective vagotomy (HSV group), and 20 patients who had had cholecystectomy (CH group). The patients' age ranged from 35 to 64 years (mean 45 years), and the average postoperative period was 9 years. None of the patients evidenced clinical or biochemical symptoms of malnutrition or malabsorption or of diseases affecting vitamin D metabolism. The function of the kidneys and the liver was normal. An age-matched group of volunteers served as a control group. The calcium dietary intake was determined using a standardized questionnaire; and the levels of serum calcium (Cas), phosphate (Ps), alkaline phosphatase (AP), and 25-hydroxyvitamin D [25(OH)D] and the excretion of Ca in a sample of fasting urine corrected for concurrent creatine excretion (FuCa/cr) were assessed by means of standard laboratory techniques. The bone mineral density (BMD) of the lumbar spine (L2-4) and femoral neck (neck-L) was determined by means of dual energy x-ray absorptiometry (DXA). The daily Ca dietary intake was lower than recommended (RDA) in 80% of the patients, with most of them ingesting less than 300 mg daily. The mean values of Cas, Ps, AP, and FuCa/cr did not differ from those in the controls. Significantly reduced 25(OH)D levels were observed in the PG group (7.0 ng/ml) (p < 0.001) and CH group (12.5 ng/ml) (p < 0.01) compared with the values in the control group (20.0 ng/ml).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

PubMedDate not supplied

Etiopathogenesis of UVB stimulated calciuria in chronic gastrointestinal patients with decreased supply of vit. D.

It was stated that in patients with chronic gastrointestinal disorders (CGD) and decreased supply of Vit. D (25/OH/D = 6.8 +/- 3.0 ng/ml) during UVB stimulated skin synthesis of Vit.D the increment of Vit.D and 25-hydroxycholecalciferol (25/OH/D) depends on the starting values of Vit.D and 25/OH/D and is accompanied by significant increment of calciuria (delta mean UCa). Before the irradiation with UVB, mean 1,25/OH/2D in age paired healthy controls (50.66 +/- 12.35 pg/ml) when compared with CGD (47.62 +/- 12.08 pg/ml) and F.1,25/OH/2D in controls (2.02 +/- 0.80) and CGD (2.03 +/- 0.46) did not differ when mean PTH in CGD (135.3 +/- 61.6 pg/ml) was significantly higher in CGD (44.6 +/- 18.54 pg/ml, p less than 0.01) than in control group. During and after UVB irradiation completion of CGD mean 1,25/OH/2D levels (129.0 +/- +31.9 pg/ml) as well as F. 1,25/OH/2D index (5.54 +/- +1.54) were rising with the maximum reached on the 14-th day which was paralleled with a subsequent drop in mean PTH (72.3 +/- 24.42 pg/ml) concentration. The data indicated that UVB stimulated calciuria in CGD patients was correlated with increased synthesis of 1,25/OH/2D and increased F. 1,25/OH/2D index which was accompanied with suppression of mean PTH.

Adult↗

PubMedDate not supplied

[Various problems related to zinc metabolism in the body].

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Adult↗

PubMedDate not supplied

[Serum digoxin level during treatment combined with amiodarone].

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Amiodarone↗

PubMedDate not supplied

Vitamin D deficiency in patients with chronic gastrointestinal disorders: response to UVB exposure.

UVB irradiation of the skin of patients with chronic gastrointestinal disorder (CGD) and decreased serum concentrations of 25-OHD (6.8 +/- 3.0 ng/ml, n = 15) result in a subsequent increase in circulating vitamin D and 25-hydroxyvitamin D (25-OHD) levels and is associated with a marked increase in calcuria (mean increase: 82 mg/d). Before UVB irradiation the mean total 1,25-(OH)2D concentration (48 +/- 12 pg/ml) and free 1,25-(OH)2D index (2.0 +/- 0.5) in CGD was not different from the values obtained in age-matched healthy controls (51 +/- 12 pg/ml and 2.0 +/- 0.8, respectively), but the mean PTH levels were significantly higher in CGD (135 +/- 62 pg/ml) than those in controls (45 +/- 19 pg/ml, p < 0.01). During and after UVB irradiation of CGD, mean 1,25-(OH)2D levels (129 +/- 32 pg/ml) as well as free 1,25-(OH)2D index (5.5 +/- 1.5) were on the rise with a maximum reached on the 14th day and were paralleled with a drop in PTH (72 +/- 24 pg/ml) concentration. These data indicate that UVB stimulated calciuria in CGD is due to increased synthesis of 1,25-(OH)2D and suppression of PTH.

Adult↗