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Biomedical subjects

R Brus

Publications and source records attributed to R Brus.

At least 127 records · Page 7Linked to original sources
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Basic pharmacological properties of a novel antiinflammatory drug tryptamide.

In rats and mice the basic pharmacological properties of tryptamide (TRP), a novel antiinflammatory substance were studied. The LD50 doses were for male rats 1260 mg/kg ip or 8.5 g/kg po, for male mice: 1980 mg/kg ip or 9.3 g/kg po. TRP produced evident antiinflammatory effects of potency comparable with those of phenylbutazone when studied by means of carrageenin-induced rat paw oedema and prostaglandin synthetase activity in vitro. TRP reversed pyrogen-induced hyperthermia in rats, elicited analgesic effects in rats, but not in mice, prolonged the time of hexobarbital sleep in rats and inhibited locomotor activity in rats and mice. TRP has not elicited side effects on the circulatory system of rats and cats. It is concluded that TRP may undergo clinical trials as a potential antiinflammatory drug. During these trials the attention should be paid to possible central side effects the drug.

Analgesics↗
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[Leukotrienes].

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Animals↗
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Antinociceptive and behavioral effects of leu-enkephalin (LENK) or D-Ala2-met-enkephalinamide (DAMEA) in rats after central chemical sympathectomy or serotoninectomy.

In rats with central chemical sympathectomy induced by two injections into the lateral brain ventricle (icv) of 250 micrograms of 6-hydroxydopamine or with central chemical serotoninectomy induced by 75 micrograms of 5,6-dihydroxytryptamine icv the antinociceptive and behavioral effects of LENK (200 micrograms icv) or DAMEA (10 or 20 micrograms icv) were examined. The chemical lesion of central noradrenaline or dopamine neurons or specific lesion of serotonin neurons abolished antinociceptive effects of LENK and DAMEA. Both peptides inhibited exploratory activity of rats. Central chemical serotoninectomy but not sympathectomy reversed some behavioral effects induced by LENK and DAMEA. These results suggest modulatory influence of the central noradrenaline and serotonin neurons in the antinociceptive mechanism of action of enkephalins and the participation of the central serotonin neurons on the behavior of rats induced by enkephalins.

5,6-Dihydroxytryptamine↗
PubMedDate not supplied

Behavioral effects of apomorphine during development of rats.

The behavioral effects of apomorphine in a dose of 1.5 mg/kg i.p. were studied in male Wistar rats at the age of 3,4,6 weeks and 3,5,6 months. Behavioral features typical for apomorphine were observed in rats from the 6th week of life. It is concluded that maturation of central dopaminergic receptors in rats occurs at about 6th week of life.

Age Factors↗
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Central action of melanostatin (MIF-1) in mice.

The effects of MIF-1 administered into a lateral ventricle of the brain were studied on the behaviour of mice in the open field test and hole test, apomorphine-induced stereotypy, morphine-induced catalepsy, and reactivity on thermal painful stimuli in the hot plate test. The last test was compared with a similar test with morphine administration. It was demonstrated that MIF-1 exerted a depressing effect on the behaviour of mice, increased the intensity of apomorphine-induced stereotypy and weakened chlorpromazine-induced catalepsy. Moreover, an analgesic action of MIF-1 was demonstrated which was blocked with naloxone. The results of these investigations indicated a significant central action of MIF-1 in mice and a participation of dopaminergic receptors in certain effects of MIF-1 on the behaviour of experimental animals.

Animals↗
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Central action of 6-hydroxytryptamine in rats.

The effects of 6-hydroxytryptamine (6-HT), an analogue of 5-hydroxytryptamine (5-HT) injected into a lateral brain ventricle of rats (i.c.v.) on the behaviour of animals spontaneous and exploratory activity as well as amphetamine and chlorpromazine influenced motor activity were studied. Moreover, 6-HT i.c.v. effect was investigated on rectal body temperature, duration and hexobarbital induced sleep, blood pressure and heart rate. In a separate series of experiments the effect of 6-HT after i.c.v. administration of 200 microgram was studied on the level of 5-HT, 5-hydroxyindoleacetic acid, noradrenaline, dopamine and acetylcholine as well as on the activity of acetylcholine esterase and acetyltransferase in the whole brain and in its various parts. It was demonstrated that 6-HT had a short-lasting inhibitory effect on the behaviour of animals and on the concentrations of biogenic amines in the brain. Although the effects of 6-HT in certain pharmacological tests used here resembled the known effects of 5-HT, it seems that the action of 6-HT on the central nervous system is of low specificity.

Animals↗
PubMedDate not supplied

Effect of prostaglandins on morphine-induced catalepsy in mice.

The effect of prostaglandins (PGs) F1 alpha, F2 alpha, E1, E2, D2, I2, A1, B1 injected into the lateral ventricle of the brain on morphine-induced catalepsy was studied in mice. The PGs were administered in doses of 1 microgram, the dose of morphine was 30 mg/kg intraperitoneally. It was found that PGs E1, E2 and D2 weakened, and F1 alpha, F2 alpha and I2 increased morphine-induced catalepsy. The results of this experiment showed a modifying effect of exogenous PGs on morphine-induced catalepsy, the effect differed depending on the prostaglandin used.

Animals↗
PubMedDate not supplied

Cataleptogenic effect of haloperidol, chlorpromazine and morphine in developing rats.

The intensity of catalepsy produced by haloperidol (0.5 mg/kg), chlorpromazine (10 mg/kg) and morphine (20 mg/kg) given ip was tested in male Wistar rats of age between 3 weeks and 6 months. The cataleptic response was most expressed in the youngest animals, and decreased with age. The results indicate that young rats show higher reactivity of central dopaminergic receptors to the investigated drugs.

Age Factors↗
PubMedDate not supplied

The diuretic action of noradrenaline and dopamine in rats with chemical serotoninectomy and central nervous system sympathectomy.

It was demonstrated that dopamine administered into the lateral ventricle of rats with chemically induced sympathectomy of the central nervous system had an evident diuretic effect observed 4 as well as 24 hours after its injection. Noradrenaline, on the other hand, increased diuresis in control rats and in those with chemical serotoninectomy, but only in the first 4 hours of the experiment. Chemical sympathectomy of the central nervous system abolished the diuretic effect of noradrenaline. The results of the experiment confirm the role of mainly dopaminergic receptors in the central regulation of diuresis in this experimental model.

5,6-Dihydroxytryptamine↗