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Biomedical subjects

R Brockett

Publications and source records attributed to R Brockett.

4 recordsLinked to original sources

Lipid-lowering therapy following major cardiac events: progress and deficits.

OBJECTIVE: To assess hospital prescribing of lipid-lowering agents in a tertiary hospital, and examine continuation of, or changes to, such therapy in the 6-18 months following discharge. DESIGN: Retrospective data extraction from the hospital records of patients admitted from October 1998 to April 1999. These patients and their general practitioners were then contacted to obtain information about ongoing management after discharge. SETTING: Tertiary public hospital and community. PARTICIPANTS: 352 patients admitted to hospital with acute myocardial infarction or unstable angina, and their GPs. MAIN OUTCOME MEASURES: Percentage of eligible patients discharged on lipid-lowering therapy and percentage of patients continuing or starting such therapy 6-18 months after discharge. RESULTS: 10% of inpatients with acute coronary syndromes did not have lipid-level estimations performed or arranged during admission. Documentation of lipid levels in discharge summaries was poor. Eighteen per cent of patients with a total serum cholesterol level greater than 5.5 mmol/L did not receive a discharge prescription for a cholesterol-lowering agent. Compliance with treatment on follow-up was 88% in the group discharged on treatment. However, at follow-up, 70% of patients discharged without therapy had not been commenced on lipid-lowering treatment by their GPs. CONCLUSIONS: Prescribing of lipid-lowering therapy for secondary prevention following acute coronary syndromes remains suboptimal. Commencing treatment in hospital is likely to result in continuing therapy in the community. Better communication of lipid-level results, treatment and treatment aims between hospitals and GPs might encourage optimal treatment practices.

Adult↗

Pseudoepidemic of Aspergillus niger infections traced to specimen contamination in the microbiology laboratory.

We report a pseudo-outbreak of Aspergillus niger that followed building construction in our clinical microbiology laboratory. Because outbreaks of invasive aspergillosis have been linked to hospital construction, strategies to minimize dust in patient care areas are common practice. We illustrate that the impact of false-positive cultures on patient care should compel laboratories to prevent specimen contamination during construction.

Aspergillosis↗

Trajectory estimation from place cell data.

We consider the problem of propagating the conditional probability density associated with the movement parameters (position, heading, velocity, etc.) of an animal, given the responses of an ensemble of place cells. While we are not the first to look at this question, ours seems to be the first treatment that incorporates a general Markov process model for the motion parameters and a general observation model postulating place cells centered in a lower dimensional 'measurement space' formed from combinations of the Markovian variables. An important part of our analysis involves the determination of a suitable set of sufficient statistics for propagating the conditional density in this context. Making use of these results we are led to approximations which greatly simplify the estimation problem and various aspects of its neuroscientific interpretation.

Action Potentials↗