Biomedical subjects

R Brand

Publications and source records attributed to R Brand.

184 records · Page 11Linked to original sources

PubMedDate not supplied

Nerve lesions in proximal humeral fractures.

In the literature nerve injury is not frequently considered a problem in proximal humeral fractures. Only a few studies exist concerning traction injury of nerves in fractures of the proximal humerus after low-velocity trauma. Almost all of them are retrospective and did not use electromyography. Patients with identical fractures can show quite different outcomes, which vary between complete recovery and severely limited shoulder function. On the assumption that nerve lesions can play a role in the recovery of conservatively and operatively treated proximal humeral fractures, we started a prospective follow-up study with electromyographic investigation. For this study, 143 consecutive proximal humeral fractures due to low-velocity trauma were included. According to the Neer classification, 93 were nondisplaced and 50 were displaced fractures. Denervation on the electromyogram was found in 96 patients (67%). The nerves most frequently involved were the axillary nerve (83 [58%]) and the suprascapular nerve (69 [48%]). Frequently a combination of nerve lesions was seen. Nerve lesions were much more frequent in displaced fractures (82% [41/50]) than in nondisplaced fractures (59% [55/93]). Complicating nerve lesions in patients older than 20 years of age were seen in about the same percentage of patients per decade. Nerve injury and the corresponding loss of muscle strength recovered well in all patients; however, the duration of the recovery was prolonged in cases with nerve lesions. Restoration of the function of the shoulder was less favorable. It is important to realize that, in both conservative and operative treatment of proximal humeral fractures, a paresis due to nerve injury can affect the restoration of shoulder motions. An electromyogram can be useful in the investigation of nerve lesions, because detection only by clinical examination proved to be very difficult. Because of the favorable electrophysiological recovery, no indication for exploration of nerve lesions was present in this series of fractures due to low-velocity trauma.

Adolescent↗

PubMedDate not supplied

Self-reference and coronary heart disease incidence in the Western Collaborative Group Study.

Previous research has indicated that the spoken frequency of the self-references "I," "me," and "my" in a structured interview was prospectively related to coronary heart disease (CHD). To assess whether the findings would replicate in another population, we conducted a case-control analysis of 750 structured interviews from the Western Collaborative Group Study. To measure self-references, auditors counted all first person pronouns (I, me, my) and clauses spoken in the audiotaped baseline structured interviews. Matched multiple logistic regression analyses, with or without adjustment for major CHD risk variables, indicated that those who incurred CHD did not self-reference more frequently or densely than the CHD-free control subjects. Type As spoke more clauses and more total self-references but did not have a higher density of self-references than Type Bs. The results question both the method for measuring self-references and the hypothesis that self-referencing are associated with CHD.

Adult↗

PubMedDate not supplied

Is alexithymia a risk factor for unexplained physical symptoms in general medical outpatients?

OBJECTIVE: Alexithymia is presumed to play an important predisposing role in the pathogenesis of medically unexplained physical symptoms. However, no research on alexithymia has been done among general medical outpatients who present with medically unexplained physical symptoms as their main problem and in which anxiety and depression have been considered as possible confounding factors. This study investigated whether patients with medically unexplained physical symptoms are more alexithymic than those with explained symptoms and whether, in patients with unexplained symptoms, alexithymia is associated with subjective health experience and use of medical services. METHODS: We conducted a cross-sectional study among patients attending an internal medicine outpatient clinic. All patients were given a standardized interview and completed a number of questionnaires. RESULTS: After complete physical examinations, 169 of 321 patients had unexplained physical symptoms according to two independent raters. Patients with medically unexplained symptoms more often had a mental disorder, but overall they were not more alexithymic. In patients with unexplained physical symptoms, alexithymia was not associated with subjective health experience or use of medical services. However, patients with both unexplained symptoms and a mental disorder who also denied any possible connection between emotional problems and their physical symptoms did have more alexithymic traits. CONCLUSIONS: In the majority of patients with medically unexplained physical symptoms, alexithymia does not play a role of clinical significance. Patients with unexplained physical symptoms are heterogeneous with respect to psychiatric syndrome pathology and probably also with respect to personality pathology.

Adult↗

PubMedDate not supplied

The diagnosis of pancreatic cancer.

Despite increasing interest and research on pancreatic cancer, patients with this devastating disease have a very poor prognosis. The principal reason for this grim prognosis is the inability to diagnose the disease at an early, localized, and curable stage. This review is intended to present an overview of our current status on the diagnosis of pancreatic cancer and emphasize recent advances in imaging and tumor markers that are attempting to overcome the challenges of this dreaded disease. Clinical presentation and risk factors for pancreatic cancer are reviewed. Various imaging modalities-including endoscopic and transabdominal ultrasound, ERCP, CT, MRI and PET-are described, with emphasis on their limitations for diagnosing pancreatic cancer at a size that has a significant impact on survival rates. The most promising approach for the early diagnosis of pancreatic adenocarcinoma utilizes tumor markers. Many of the tumor markers investigated over the past 20 years as well as some promising markers under current investigation are reviewed. The combination of serum markers may improve sensitivity and specificity in making the diagnosis of pancreatic adenocarcinoma. We conclude that the current status of imaging and tumor markers does not permit the early diagnosis of an adenocarcinoma of the pancreas. The development of improved early detection methods for pancreatic cancer is essential; however, at the present time it should be limited to high-risk individuals to allow for a better opportunity for success.

Biomarkers, Tumor↗