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Biomedical subjects

R Boyle

Publications and source records attributed to R Boyle.

At least 73 records · Page 4Linked to original sources
PubMed1988

Neuronal activity in the flocculus of the alert monkey during sinusoidal optokinetic stimulation.

1. Activity of single units was recorded in the flocculus of alert, behaving monkeys during sinusoidal optokinetic (0.02-5.0 Hz), constant velocity optokinetic, vestibular and visual-vestibular conflict stimulation. The maximal stimulus velocity for sinusoidal optokinetic stimulation at different frequencies was 40 deg/s or less (at frequencies above 1 Hz). For an amplitude series at 0.2 Hz, stimulus velocity was varied between +/- 10 to +/- 80 deg/s. In one trained monkey activity was also investigated during smooth pursuit eye movements and suppression of the vestibulo-ocular reflex by visual fixation (VOR-supp.). Only neurons which responded to 0.2 Hz (+/- 40 deg/s) optokinetic stimulation were included in the study. 2. The majority of neurons (44 out of 59) were type I Purkinje cells (PCs), which increased their simple spike activity during optokinetic cylinder rotation to the ipsilateral recording side. The responses during other, vestibular related, paradigms allowed all these neurons to be classified as so called 'gaze velocity' PCs. Three type II PCs were encountered, which responded similarly, but were only weakly modulated. 3. All type I PCs were modulated at frequencies of sinusoidal optokinetic stimulation between 0.05 and 2.5 Hz. PC's showed little or no modulation at 0.03 and 0.02 Hz. About half of the PC's still responded at 5.0 Hz. 4. Relative to eye velocity, the PC activity had a phase advance of about 30 deg between 0.1 and 2 Hz. It became larger at lower, and smaller at higher, frequencies. Eye velocity related sensitivity (imp/s/deg/s) was small at low stimulus frequencies and increased monotonically, on average from 0.16 at 0.02 Hz to 2.0 at 3.3 Hz. 5. Ten (out of 12) mossy fiber related input neurons were classified as visual neurons, since their activity could be related to the amount of retinal slip in all conditions. Neurons were clearly modulated at sinusoidal optokinetic stimulation up to 5 Hz. One input neuron, investigated during sinusoidal OKN, smooth pursuit eye movements, VOR and VOR-supp., behaved qualitatively like a 'gaze velocity' PC. The remaining input neuron encoded eye velocity at 0.2 Hz optokinetic, vestibular and visual-vestibular conflict stimulation. 6. The results show that during sinusoidal and constant velocity optokinetic stimulation 'gaze velocity' PC's do not encode eye velocity and/or eye acceleration. 7. The vestibular nuclei-flocculus complementary hypothesis (Waespe and Henn 1981) can explain PC responses to a large extent.(ABSTRACT TRUNCATED AT 400 WORDS)

Action Potentials↗
PubMed1988

Acute headache.

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Adult↗
PubMed1986

Assessment of the effect of nifedipine on myocardial ischaemia by using the ST segment/heart rate slope.

Nifedipine is used in patients with stable angina of effort and any resulting change in symptoms is attributed to several effects of nifedipine. However, there have been indications in such patients that one effect of nifedipine could be an increase in the severity of myocardial ischaemia, and the present report involves a trial the results of which could explain this effect. In the present trial, the effect of nifedipine on myocardial ischaemia was assessed by using the maximal ST/heart rate slope. This slope was used as an index of myocardial ischaemia because, in our hands in patients with angina, an increase or a decrease in the value of the slope respectively indicated an increase or a decrease in the severity of myocardial ischaemia as assessed by coronary arteriography. The maximal ST/heart rate slope was obtained at least twice in each of 23 patients with stable angina, with and without nifedipine; two patients were examined twice and three other patients were examined after an increased dose. Nifedipine resulted in an increase in the slope in 24 of the 28 comparisons, no change in three and a decrease in one comparison; there was a statistically significant (P less than 0.005; n = 28; paired t-test) increase in the maximal ST/heart rate slope. A further increase in the slope was obtained by increasing the dose of nifedipine in two out of three patients. The increase in the maximal ST/heart rate slope occurred in the absence of any effect of nifedipine on the initial level of ST segment.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1986

Ambulatory surgery.

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Ambulatory Surgical Procedures↗
PubMed1985

Vestibular nuclei activity and eye movements in the alert monkey during sinusoidal optokinetic stimulation.

In the alert monkey (Macaca fascicularis) vestibular nuclei neurons and eye movements were recorded during sinusoidal optokinetic stimulation in the horizontal plane at frequencies between 0.02-3.3 Hz. Maximal stimulus velocity was generally kept constant at 40 deg/s, except for frequencies above 1 Hz. Eye movements showed a nystagmus-like pattern up to 0.2 Hz with a gain (change in eye position/change in cylinder position) greater than 0.8; at frequencies above 1 Hz the gain dropped to 0.35 at 3.3 Hz. A decrease in gain was accompanied by an increasing phase lag. Recordings in the vestibular nuclei were obtained from 'vestibular only' and 'vestibular plus saccade' neurons. Neurons with a strong eye position signal ('vestibular plus position') were excluded. The vast majority (87%) of neurons were not modulated at 0.2 Hz or higher frequencies of sinusoidal optokinetic stimulation, and were classified as 'low-frequency' type neurons. Compared to the response at constant stimulus velocity, sensitivity (imp X s-1/deg X s-1) dropped to 72% at 0.03 Hz and 16% at 0.1 Hz. A few neurons (13%) responding at 0.2 Hz (sensitivity on average 65% of the constant velocity response) were classified as 'high-frequency' type neurons. They did not respond above 1.0 Hz and showed no modulation with individual eye movements. The results suggest that the activity in the groups of vestibular nuclei neurons tested here is insufficient to account for the eye movements in response to sinusoidal optokinetic stimulation at frequencies above 0.1 Hz.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1985

Pre-excitation due to accessory sinoventricular connexions associated with coronary sinus aneurysms. A report of two cases.

Ventricular pre-excitation occurred in two cases in which the accessory pathways between the atria and the ventricles were histologically identified as being associated with aneurysmal malformations of the coronary sinus. In one case the connexions were in the posterior wall of the coronary sinus aneurysm and were not related to the atrioventricular annulus; in the other, a connexion was situated in the anterior wall of the aneurysm in close apposition to the annulus and superficially resembled a Kent fibre. These connexions were considered to be of sinus venosus origin and to represent a modification of the muscular sheath that normally surrounds the coronary sinus but does not continue along the coronary veins. One of the posterior wall connecting bundles was composed of abnormally large Purkinje-like fibres; this may have played some role in the manifestation of the pre-excitation by reducing any mismatch impedance.

Adolescent↗
PubMed1984

Discharge activity of spindle afferents from the gastrocnemius-soleus muscle during head rotation in the decerebrate cat.

The activity of spindle afferents originating from both primary and secondary endings of the isometrically extended (6-8 mm) gastrocnemius-soleus (GS) muscle was recorded in precollicular decerebrate cats during sinusoidal head rotation about the longitudinal axis above a stationary body. In the first group of experiments to test the influence of vestibular volleys on fusimotor neurons, an acute bilateral neck deafferentation at C1-C3 was performed to eliminate possible influences arising from neck receptors; head rotation (0.026 Hz, +/- 15 degrees) induced a weak periodic rate modulation in 6/38 (15.8%) of the tested spindle afferents; the average response gain was 0.18 +/- 0.12, SD imp./s/deg (mean firing rate, 18.9 +/- 2.8 imp./s), and the average phase angle was -43.2 +/- 47.0 degrees, SD lag with respect to ipsilateral side-down displacement of the head (alpha-response pattern). In a second group of experiments head rotation studied after acute bilateral section of VIII cranial nerve, thereby stimulating only neck receptors, failed to influence in a reliable manner the firing rate of 38 additional spindle afferents. In a third group of experiments in which both VIII nerves and cervical dorsal roots were left intact, head rotation induced a response in 7/45 (15.6%) of the tested spindle afferents similar to that observed after cervical deafferentiation and thus depended on stimulation of labyrinth receptors alone. Over the examined frequency range of head rotation from 0.015 to 0.325 Hz (+/- 15 degrees), the response gain of spindle afferents was relatively stable during sinusoidal labyrinth stimulation. For most of the spindle afferents the phase angle of the response elicited at the lower frequencies was related to the direction of head orientation towards the ipsilateral sidedown, thus being attributed to labyrinth volleys originating from macular receptors; at 0325 Hz the stimulus was less effective and some units showed a phase advance relative to head position which was attributed to costimulation of canal receptors. Displacement of the muscle under study obtained by either rotation of the whole animal or body alone beneath a stationary head elicited a periodic modulation of spindle afferent discharge, independent of head orientation or type of preparation, in 51/73 (70%) of the muscle spindles tested; the average response gain was 0.20 +/- 0.19, SD imp./s/deg, and an average phase lead of +14.1 +/- 20.5 degrees, SD with respect to the peak of the ipsilateral side-down displacement of the body or of the animal was observed.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗
PubMed1982

Detection of severity of coronary artery disease by the ST segment/heart rate relationship in patients on beta-blocker therapy.

Many patients presenting with anginal pain are on beta-blocker therapy and it has been suggested that noninvasive exercise tests for coronary artery disease are adversely affected by such therapy. Recently a new exercise test has been introduced claiming the ability accurately to detect the presence and severity of coronary heart disease in patients with anginal pain; the claim was based on results obtained in patients not undergoing beta-blocker therapy. Therefore using this test, the maximal rate of progression of ST segment depression relative to increases in heart rate during exercise (maximal ST/HR slope) as an index of the severity of myocardial ischaemia, 60 patients on beta-blocker therapy were studied and the results compared with results of coronary arteriography independently obtained. There was a complete agreement, without false results, between the maximal ST/HR slope and the number of significantly diseased coronary arteries. In 21 of these 60 patients the maximal ST/HR slopes obtained before and after beta-blockade were compared; the maximal ST/HR slopes after beta-blockade were not different from those before. It is concluded, that the maximal SR/HR slope can be used reliably to detect the pressure and the severity of coronary heart disease in patients with angina pectoris who are already on beta-blocker therapy.

Adult↗
PubMed1982

Accurate detection of coronary heart disease by new exercise test.

The ability of a new exercise test accurately to detect the presence and severity of coronary heart disease has been examined in 206 patients with anginal pain, including patients on beta blockers or with concomitant cardiac lesions. From recordings of 13 electrocardiographic leads during exercise, the maximal rate of progression of ST segment depression relative to increased in heart rate (maximal ST/HR slope) was obtained and used as an index of myocardial ischaemia. The maximal ST/HR slope and results of coronary arteriography were independently obtained and the two sets of data compared the ranges of the maximal ST/HR slopes in the 38 patients with no significant disease, 49 with single vessel, 75 with double vessel, and 44 patients with triple vessel disease were different from each other and there was no overlap in the data between adjacent groups; there were no false positive, false negative, or indeterminate results. It is concluded that the maximal ST/HR slope can be used reliably to predict the presence of absence and severity of coronary heart disease in individual patients presenting with anginal pain in a hospital population.

Adrenergic beta-Antagonists↗
PubMed1981

Responses of vestibulospinal neurons to neck and macular vestibular inputs in the presence or absence of the paleocerebellum.

1. The role of the paleocerebellum in determining the responses of lateral vestibular nucleus (LVN) neurons either to independent or combined stimulation of macular vestibular and neck receptors has been investigated in decerebrate cats. Sinusoidal rotation around the longitudinal axis at 0.026 Hz, 5-10 degrees, represented the constant input parameters. Among the tested neurons, 100 and 131 units were recorded in animals with intact cerebellum and following partial cerebellectomy, respectively. The units were classified according to their anatomical location in either the rostroventral (cLVN) or dorsocaudal (ILVN) part of the LVN; units also were activated antidromically from the spinal cord. 2. The majority of units responded to stimulation of macular receptors both in preparations with intact cerebellum (75.0%) or with partial cerebellectomy (71.8%), the response being primarily in phase with the direction of animal orientation. The proportion of responding units and their response sensitivity were greater in the cLVN than ILVN in each preparation; no significant differences in mean firing rate and response sensitivity were observed between the two preparations for each subdivision of the LVN. In animals with cerebellum intact, the majority of cLVN and ILVN units were excited during side-down tilt; following partial cerebellectomy, this predominant response pattern still was present in cLVN but was reversed in ILVN. 3. About one-half of the units responded to sinusoidal stimulation of neck receptors in both preparations, the response being mainly in phase with the direction of neck orientation. In the intact cerebellum preparations, the proportion of cLVN units responding to neck rotation was greater than that of ILVN units, but no difference in response sensitivity was observed between these units. Following partial cerebellectomy, the proportion of cLVN units responsive to the neck input was reduced but that of ILVN units was not; however, the average response sensitivity was halved for both cLVN and ILVN units. In preparations with cerebellum intact, most of the cLVN units were excited during side-down neck rotation, whereas ILVN units were excited mainly by rotation in the opposite sense; following partial cerebellectomy, the majority of units were excited during side-up neck rotation, not only in ILVN but also in cLVN. 4. Units receiving a convergent input from both receptors were more numerous in cLVN (72.7%) than ILVN (41.8%) in preparations with intact cerebellum; following partial cerebellectomy, this disproportion of responsive units in the two divisions (45.3% and 44.9%, respectively) disappeared, due to a reduced number of cLVN units responding to the neck input. In both preparations, the macular input had a relatively greater influence on the cLVN whereas the neck input was more effective on the ILVN. 5...

Acceleration↗
PubMed1981

Relation between cell size and response characteristics of vestibulospinal neurons to labyrinth and neck inputs.

(1) The activity of 136 Deiters' neurons projecting to lumbosacral segments of the spinal cord has been recorded in decerebrate, partially cerebellectomized cats, and their response characteristics to sinusoidal stimulation of labyrinth and neck receptors have been related to cell size inferred from the conduction velocity of the corresponding axons. (2) Vestibulospinal neurons with faster conduction velocity and, by inference, having thicker axons and larger cell bodies differed from those neurons having lower axonal conduction velocity by displaying (i) a relatively irregular interspike interval distribution; (ii) a lower resting discharge rate; (iii) a periodically modulated response to the labyrinth input elicited by sinusoidal tilt around the animal's longitudinal axis (0.026 Hz, 10 degrees) characterized by an increase in firing rate during side-down roll tilt; (iv) an increase in gain (impulses per sec per degree) and phase lag relative to the displacement of the labyrinth response to increasing angular acceleration; (v) a greater gain in labyrinth than neck input, the latter elicited by sinusoidal neck rotation (0.026 Hz, 5 or 10 degrees); and (vi) due to the imbalance of the gains of the separate labyrinth and neck responses and their predictable vectorial summation, a response to both inputs elicited by head rotation resembling that obtained by labyrinth stimulation alone. (3) These findings are discussed in terms of the reciprocal distribution of synaptic contacts of vestibular and neck afferents on vestibulospinal neurons as a function of cell size. The evidence indicates that, in addition to intrinsic neuronal properties related to cell size, the quantitative and qualitative organization of synaptic inputs represents the critical factor controlling the responsiveness of vestibulospinal neurons.

Action Potentials↗
PubMed1980

Diffuse involvement of the leptomeninges by tumour--a clinical and pathological study of 63 cases.

The clinical and pathological features of 63 cases of post-mortem-proved diffuse infiltration of the leptomeninges by tumour are presented. A wide variety of tumours of the nervous system, both primary and secondary, was found to give rise to such involvement, with adenocarcinoma having a particular propensity to behave in this manner. Dysfunction of cranial and spinal nerves, a confusional state and headache were prominent clinical features. Examination of the cerebro-spinal fluid was found to be less useful diagnostically in cases of primary tumours of the nervous system with leptomeningeal involvement than in cases of diffuse infiltration of the meninges by carcinoma.

Adult↗