[Our 1st experiences with the stimulation of gonadotropic releasing hormones (GnRH - LH/FSH)].
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Adult↗
Biomedical subjects
R Borota
Publications and source records attributed to R Borota.
[Clinical use of granulocyte colony stimulating-factors (GM-CSF and G-CSF].
Humoral regulation of granulocytopoiesis was proven 30 years ago by discovery of factors which stimulate production of granulocyte colonies (CSF-colony stimulating factors), while clinical utilization of recombinant human colony stimulating factors (rhGM-CSF and rh-CSF) is present for the last 10 years. On the basis of this, today we have a lot of experience in regard to indications, modes and results of their clinical utilization. Clinical utilization of CSF is divided into three fields: treatment of the neutropenic syndrome, utilization in oncologic patients and in bone marrow transplantation. The best results have been achieved in neutropenic syndrome therapy, both chronic (congenital, cyclic and idiopathic neutropenia, aplastic anemia and myelodysplastic syndrome) and acute (granulocytopenia drug induced, postirradiation neutropenia). In oncologic patients it is used to eliminate neutropenia which occurs after cytostatic therapy with standard doses or high dose cytostatic therapy with better effects on the tumor, but with myeloablation. Granulocyte colony-stimulating factor is also used for stimulating fast granulocytopoiesis in autologous or allogeneic bone marrow transplantation, in unsatisfactory transplants especially. In recent years it has been used for mobilization of progenitor CD34+ cells in the donor in order to perform their transplantation, especially in treatment of chronic myeloid leukemia. At our institution G-CSF has been successfully used in 17 patients.
Bone Marrow Transplantation↗
[The role and achievements in clinical pathophysiology in the Novi Sad region].
Nowadays, clinical pathophysiology in our conditions is a firmly founded branch of medicine which has had an important role in the improvement of diagnostics, scientific and researching work and all forms and levels of education at the Medical Faculty in Novi Sad. The value and usefulness of clinical pathophysiology has been particularly important in the team work within the Clinical center in Novi Sad in the time it was organized as an unique health care institution. Pathological physiology was ready to take over all its tasks foreseen within this type of organization, and through further constructional and equipment improvements it could soon achieve European standards in its work. Professionally unjustified decision for abandoning the concept of Clinical center in Novi Sad has greatly affected health care service in general. Twenty years of work on the improvement of pathophysiology have been thrown away and its important role in the first-class treatment of the patients has been certainly discredited but not denied. If health care service happens to be reorganized following the model of developed countries there will be a chance for the revitalization of clinical pathophysiology and finalization of its development to fulfill the interests of patients for obtaining the high quality treatment in our conditions.
Health Services↗
Effect of serum from thrombocytopenic patients on platelet count in blood of mice.
Estimation of the effect of sera obtained from patients suffering from several forms of megakaryocytic (immune) thrombocytopenia (19), and those with acute non-lymphoblastic leukemia (13), on the platelet count in the peripheral blood of mice was carried out. Several groups of mice were injected intravenously with 0.2 ml of patients' sera, and the platelet count was followed up for 10 days. A marked and highly significant decrease of platelet count in recipient mice was established even 6 hours after the application of both groups of patients' sera. In the control group of mice receiving pooled serum of healthy persons this decrease was not registered. It can be presumed with great probability that the mechanism of development of thrombocytopenia in both groups of patients is very similar: there is an extremely increased destruction of platelets in the peripheral blood in cases with immune thrombocytopenia by antibodies, and in cases with acute leukemias by antibodies and/or other cytotoxic substances. In further investigations the influence of thrombopoietin on this phenomenon will be tested.
Animals↗