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Biomedical subjects

R Bluhm

Publications and source records attributed to R Bluhm.

24 records · Page 2Linked to original sources
PubMed1990

Aplastic anemia associated with canthaxanthin ingested for 'tanning' purposes.

Aplastic anemia with a fatal outcome occurred in a previously healthy young woman after ingesting canthaxanthin taken for the purpose of skin "tanning" and provided to her by a commercial tanning salon. Canthaxanthin is a synthetic, non-provitamin A carotenoid that is highly lipid-soluble; it colors the skin by deposition in the epidermis and subcutaneous fat. It is readily available through commercial tanning salons and mail advertisements, but despite advertising claims that it is harmless, investigation regarding the safety of oral doses of canthaxanthin in humans has not been conducted. It is not approved as a prescription or an over-the-counter preparation by the Food and Drug Administration. The drug's present means of distribution makes monitoring for toxic effects difficult. Thus, the frequency of adverse effects associated with canthaxanthin use, such as bone marrow suppression, is unknown. Even if there is only a small risk of these toxic effects, the use of the drug for cosmetic purposes does not justify this risk.

Administration, Oral↗
PubMedDate not supplied

Potentiation of opioid analgesia by H1 and H2 antagonists.

The finding that abusers of pentazocine and tripelennamine experience a heroin-like euphoria which neither drug alone can produce prompted this study on the possible potentiation of opioid analgesia by H-antagonists. The reaction to pain in seconds was assessed at the time of peak drug effect by measuring the latency to jump from a hot plate at 55 degrees C after drug administration in male Swiss Webster mice. Several H1 antagonists and the H2 antagonist cimetidine markedly potentiated analgesia of opioids (morphine, fentanyl and nalbuphine). No motor impairment occurred with any of the drugs and drug combinations at the doses studied. It is hypothesized that the H-antagonists may produce these effects by peripheral mechanisms or by a central action.

Analgesia↗
PubMedDate not supplied

Ciclopirox (Loprox) gel for superficial fungal infections.

Ciclopirox (Loprox) is a broad-spectrum antifungal medication that also has antibacterial and anti-inflammatory properties. Its main mode of action is thought to be its high affinity for trivalent cations, which inhibit essential co-factors in enzymes. Clinical trials have shown that ciclopirox gel is a successful treatment for seborrheic dermatitis of the scalp as well as for tinea pedis. Adverse effects are generally mild and include a skin-burning sensation, contact dermatitis, and pruritus. Ciclopirox is indicated in the US for the treatment of tinea pedis, tinea corporis, pityriasis versicolor, seborrheic dermatitis, and cutaneous candidiasis.

Administration, Topical↗
PubMedDate not supplied

Ciclopirox shampoo for treating seborrheic dermatitis.

Seborrheic dermatitis is a common inflammatory skin disease, affecting between 1% and 3% of immunocompetent adults. While its cause is unknown, a number of predisposing factors have been reported, including the implications of Malassezia yeasts. Various treatment options are available, such as ciclopirox shampoo, which combines anti-Malassezia activity with an anti-inflammatory action. This agent has been shown to be an effective and safe treatment for seborrheic dermatitis of the scalp.

Administration, Cutaneous↗