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Biomedical subjects

R Blackburn

Publications and source records attributed to R Blackburn.

At least 37 records · Page 2Linked to original sources
PubMed1988

Phase II study of fludarabine phosphate in patients with advanced colorectal carcinoma.

For phase II studies in patients with solid tumors, the National Cancer Institute recommended that the starting dose of fludarabine phosphate be 20 mg/m2/day as a short intravenous infusion for 5 days every 21 days. Twenty-one patients with untreated, advanced, measurable colorectal carcinoma received fludarabine phosphate as a 30-minute infusion at a median dose of 25 mg/m2/day (range 15-35 mg/m2/day) for 5 consecutive days repeated every three weeks. Antitumor response was evaluated following two courses of therapy. No patient achieved complete or partial response. Minor regression of lung metastases occurred for less than 12 weeks in one patient. Therapy was generally well tolerated. Frequent toxicities included lymphopenia, mild nausea and vomiting, mucositis, and anorexia. One patient died of sepsis, bleeding, and progressive disease while she was severely myelosuppressed. Neurotoxicity was not observed in any patient. Fludarabine phosphate at this schedule and dose range is inactive against colorectal carcinoma.

Adult↗
PubMed1988

Interpersonal style and personality deviation.

Forensic psychiatric patients were assigned to empirically derived categories of personality deviation, and described their interpersonal reactions in situations of threat and affiliation. Differences between groups were maintained across situations, and support the utility of conceptualizing personality disorders in terms of inflexible interpersonal styles.

Antisocial Personality Disorder↗
PubMed1986

Cadmium-induced changes in renal hemodynamics in the domestic fowl.

Low i.v. doses of cadmium chloride (15 micrograms Cd) given to pullets resulted in a significant reduction in urine flow (UF), glomerular filtration rate (GFR) and effective renal plasma flow (ERPF). However, in hens treated with the heavy metal chelate FeNa EDTA prior to cadmium treatment no oliguria or reduction in GFR or ERPF was observed. It is suggested that the renal changes following the i.v. administration of cadmium to diuretic hens and alleviated in hens primed with the heavy metal chelate may result from changes in glomerular hemodynamics.

Animals↗
PubMed1985

Reactions of primary and secondary psychopaths to anger-evoking situations.

Offender patients at a psychiatric security hospital were classified as primary or secondary psychopaths or as conforming or inhibited non-psychopaths, and compared on a Situations-Reactions Inventory of Hostility. Prior factor analysis of this inventory indicated two classes of situation, labelled attack and frustration, and three classes of reaction - aggression, anger, and arousal. Psychopathic subjects generally rated their reactions as more intense but differed significantly from non-psychopaths only in their response to attack. Secondary psychopaths produced the most intense reactions, but differed from primary psychopaths in reporting greater somatic arousal. The results suggest that psychopaths as a group more readily interpret provocation or threats from others as unwarranted attack. It is proposed that an attributional bias towards perceiving malevolent intent may be central to psychopathy.

Aggression↗
PubMed1979

Psychopathy and personality: the dimensionality of self-report and behaviour rating data in abnormal offenders.

Factor analyses of personality test data in two samples of offenders admitted to psychiatric security hospitals yielded two higher order factors identified as psychopathy or antisocial aggression versus conformity, and social withdrawal versus sociability. One sample was also rated for ward behaviour by nursing staff, and similar factors emerged from the behaviour rating data. The self-report dimension of psychopathy correlated significantly with the corresponding rating dimension at the time of admission and, for medicated subjects only, with ratings obtained 2 years later. Cross-media convergence of the withdrawal dimension was not found at the time of admission, but for unmedicated subjects, initial self-reports correlated significantly with the equivalent rating dimension as assessed 2 years later. The two dimensions therefore appear to measure meaningful behavioural dispositions. While they define the same dimensional space as neuroticism and introversion--extraversion, they appear to provide a more appropriate framework for classification within this population of offenders.

Adult↗
PubMed1975

Am empirical classification of psychopathic personality.

Personality profiles of 79 non-psychotic male offenders admitted to a security hospital were subjected to a cluster analysis. Four profile types were generated, classifying four-fifths of the sample, and differences were found between the types in previous antisocial behaviour. Two of the types were identifiable as primary and secondary psychopaths, while the remaining two showed little resemblance to the concept of the psychopathic personality. The primary psychopaths were extraverted but not neurotic, while the secondary psychopaths were neurotic, but not extraverted. Both were highly impulsive but distinguished by a dimension of sociability-withdrawal.

Adult↗