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Biomedical subjects

R Bittner

Publications and source records attributed to R Bittner.

At least 181 records · Page 10Linked to original sources
PubMed1976

Insulin response and portal-peripheral insulin difference during the oral glucose tolerance test in patients after abdominal operations.

Following abdominal surgery, insulin and glucose concentrations in the portal vein, and a peripheral vein are compared in patients during control periods and after oral administration of glucose. During the control period, the glucose concentrations are identical in both veins. After glucose loads with the prompt increase of portal glucose concentration the portal-peripheral difference also increases (p less than 0.01). During the control period the insulin concentration in the portal vein is double as compared to peripheral blood (p less than 0.005). After glucose load the increasing portal insulin as well as the peripheral and portal glucose correlate with the portal-peripheral insulin difference (p less than 0.001). Furthermore, there is a significant positive correlation between the peripheral glucose area as a parameter of glucose tolerance and the portal insulin area as a semiquantitative parameter of insulin secretory capacity (p less than 0.001). It can be concluded that in the early postoperative period in patients with a diminished oral glucose tolerance (large glucose areas) there is an even greater insulin response in comparison to patients with normal oral glucose tolerance. On the other hand, however, in those patients with diminished glucose tolerance, the insulin response is essentially delayed.

Abdomen↗
PubMed1976

[Studies of the relationship of gastric motility, gastrin secretion and HCl biosynthesis in patients with duodenal ulcer].

Serum gastrin, acid output and gastric emptying were measured in patients with duodenal ulcer. 1. Eighty-two patients with duodenal ulcer evacuate a semisolid meal with differing patterns: rapid (n = 24), normal (n = 46), and delayed (n = 12). 2. Comparing patients with rapid and delayed gastric emptying, basal and peak serum gastrin and integrated gastrin output are significantly higher in the rapid emptying group.

Adult↗
PubMed1975

[Glucose-assimilation and dynamics of insulin secretion. Measurements after intra-abdominal operations (author's transl)].

Insulin concentrations in peripheral venous blood and portal venous blood were measured in 18 patients after intraabdominal operations during 20 standardised glucose-infusion-tests (GIT). The conclusion is as follows: 1. In spite of similar preoperative situations and operative traumatisation the islets reactivity to a constant hyperglycemia and the glucose assimilation is individually ver different. 2. Measurements of insulin concentrations in the portal venous blood in man show a significant correlation between the profile of the insulin concentration curve and the k-value; the measurement of the insulin concentrations in peripheral venous blood fails to demonstrate a significant difference. 3. In patients with a pathologic glucose assimilation it is not the insulin secretion that is delayed but the insulin regression (disappearance rate) in portal venous blood. 4. In patients with a normal glucose assimilation the insulin concentrations curve in portal venous blood shows an oscillating course during the first 30 min. These oscillations registered for the first time in humans indicate an insulin-induced feedback mechanism of insulin secretion.

Abdomen↗
PubMed1975

[Diagnosis and operative treatment of coelic-artery compression].

Stenosis of the coeliac artery by compression occurs predominantly in youngish patients and three times more frequently in women than men. It gives rise to abdominal symptoms, due to chronic disturbance of intestinal arterial supply. In eight patients, operated on for this condition, the characteristic symptoms were of abdominal pain, epigastric vascular sounds, loss of weight, nausea and vomiting. Diagnosis could only be made by angiography of the coeliac and (or) mesenteric arteries, and lateral aortography. Analysis of 240 cases reported in the literature indicates that the condition is caused by compression of the coeliac artery by the medial arcuate ligament of the diaphragm, and only in a few instances by nerve tissue of the mesenteric ganglion of the coeliac plexus. Operative treatment (decompression of the artery) removes symptoms in 83% of cases.

Adult↗
PubMed1975

[Extragastric gastrin liberation. Studies on patients following gastrectomy and duodenopancreatectomy].

28 investigations were performed in control patients with no gastric disease (n equals 10), in patients after total gastrectomy (n equals 10) and in patients after duodenopancreatectomy (n equals 8). We measured the serum gastrin concentrations in the fasting state and after the ingestion of a test meal. The results indicate that more than 60% of the gastrin activity is released from extragastric sites and in addition, it is supposed that about 20% are released from extragastric and extraduodenal sites.

Aged↗