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Biomedical subjects

R Bhaskaran

Publications and source records attributed to R Bhaskaran.

36 records · Page 2Linked to original sources
PubMed1989

Neurological manifestations of homocystinuria.

Six cases of homocystinuria with different clinical manifestations are described. Two of these patients presented with vascular problems, two had proximal muscle weakness, one each had cerebellar ataxia and psychiatric manifestations. Biochemical defects and the pathological mechanisms in different types of homocystinurias are reviewed.

Adult↗
PubMed1984

Differential equation model to study dynamic behaviour of globular proteins.

By regarding the globular proteins as spheroidal shaped bodies of uniform density, a differential equation model to study their low amplitude fluctuations was developed. It was then applied to the crystal structures of pancreatic trypsin inhibitor and ferrocytochrome c. The results were tested by comparing them with those of the dynamic simulation and temperature factor studies on the same proteins.

Animals↗
PubMed1984

Dynamics of amino acid residues in globular proteins.

The dynamic differential equation model developed and tested for bovine pancreatic trypsin inhibitor and tuna ferrocytochrome c in Ponnuswamy, P.K. & Bhaskaran, R. (Int. J. Peptide Protein Res. 24, 168-179, 1984) is extended for 17 more protein crystals in this work. Average displacements are computed for 20 amino acid residues observed in 19 proteins. Detailed information on the dynamic behaviour of the individual proteins and individual residues is presented. The effect of atomic packing on the fluctuations of the amino acid residues in alpha-chymotrypsin is illustrated. A number of general points on the dynamic characteristics of globular protein molecules are presented.

Amino Acids↗
PubMed1982

Internal fluctuations in globular proteins.

An attempt was made to study the dynamics and hence the fluctuations in globular proteins treating them as prolate and oblate spheroidal bodies. The fluctuations were obtained by solving the dynamical differential equation of motion derived from the elastic stress-strain relations. The results provide information on the nature of variation of the displacement of the atoms due to fluctuations in the distance from the central of the protein.

Elasticity↗
PubMedDate not supplied

A study of combustibility of wastes of two hospitals for determining disposal by incineration.

Determination of quantity, quality and characteristics of the wastes of two hospitals located in the same sector of a class B city was undertaken to review the present dumping method of disposal. On an average 1,424.71 and 224.6 kgs. of five types of wastes as per the moisture content were found daily for seven days in these two hospitals of 1000 general beds, and 600 long stay beds for chest tuberculosis and other Cardiothoracic diseases respectively. The wastes of first hospital had higher combustibility due to its sprawling nature and activities for general patients than that of the second multistoreyed hospital treating special cases. A combustibility analysis of hospital wastes would help to decide whether to adopt incineration for disposal.

Hospitals↗