Biomedical subjects

R Bevilacqua

Publications and source records attributed to R Bevilacqua.

At least 19 recordsLinked to original sources

PubMed2004

Disposition of 4,6,4'-trimethylangelicin in mice maintained in the dark and after UVA irradiation.

The disposition of the furocoumarin 4,6,4'-trimethylangelicin (4,6,4'-TMA) was studied in mice. After oral administration of (3)H 4,6,4'-TMA, radioactivity measured in serum shows fast absorption and slow elimination. Serum protein binding is higher as compared to 8-methoxypsoralen (8-MOP), currently used in photochemotherapy (PUVA) and linearly declines from 30 min to 6 h after administration. Distribution in the various organs was similar to that of 8-MOP and was relatively uninfluenced by UVA radiation, required for the biological effects of 4,6,4'-TMA. Mice eliminate (3)H 4,6,4'-TMA mostly through the urine, but also through the faeces. Two metabolites were identified in the urine and serum of the treated mice, one of which proved to be a derivative of 4,6,4'-TMA, formed by hydrogenation of the double 4',5' bond of the furocoumarin nucleus.

Animals↗

PubMed1998

Long-term follow-up of cranial bone graft in dorsal nasal augmentation.

A follow-up of 363 cranial bone grafts for nasal reconstruction is presented. The main indications for the surgery were congenital, posttraumatic, or postrhinoplasty deformity. The results were satisfactory in the vast majority of cases. The complications associated with the grafts and with the donor site are discussed, as are the methods to treat and prevent these complications from occurring.

Adult↗

PubMed1991

Studies on 8-methoxypsoralen tolbutamide interactions. 2. Studies after U.V.-A irradiation in vitro and in vivo.

Previous studies had evidenced that tolbutamide has influence on the complex formation between 8-methoxypsoralen (8-MOP) and serum albumin, both in vitro and in vivo, partially displacing it from its binding site. We have now extended this research by studying competition under UV-A irradiation, thus approaching the conditions which occur during PUVA therapy more closely. Research was first carried out in vitro, studying tolbutamide competing with bound 8-MOP in human serum after irradiation with UV-A. From the data obtained, it appears that the displacement is not influenced to any significant extent by irradiation. Experiments were then carried out in vivo on mice treated with the two drugs and irradiated with UV-A in conditions analogous to those generally used for PUVA therapy; the amount of 8-MOP localized in blood serum and in various organs was then determined. Concerning distribution of 8-MOP, results confirmed what had been previously obtained; concerning irradiation, results showed that the effect on the 8-MOP displacement by tolbutamide was not statistically significative in the most organs considered. A slight difference in respect to the results obtained without irradiation was observed only in the cases of skin, eyes and ears.

Adult↗

PubMed1991

Studies on 8-methoxypsoralen tolbutamide interactions in vitro and in vivo.

The present study aimed at characterizing the influence of tolbutamide on the distribution of 8-methoxypsoralen (8-MOP) in mouse serum and organs. Experiments performed in vitro clearly showed that tolbutamide causes competitive displacement of 8-MOP from its binding sites on human serum albumin. Similarly, the amount of labelled compound(s) bound in serum after oral administration of 3H-8-MOP to mice was significantly reduced when tolbutamide was given by the same route. The quantitative distribution of radioactivity from 3H-8-MOP in mouse tissues varied according to organ (liver, intestine, skin, etc.,), and was maximum in the organs of elimination. In all the organs studied, the administration of tolbutamide 2 hours after that of 3H-8-MOP caused a dose-dependent reduction of the radioactive compound(s) present in tissues, suggesting that tolbutamide may accelerate the excretion of 8-MOP and/or its metabolites from the body.

Animals↗

PubMed1990

[Evoked phonomyography of the human masseter muscle].

Sounds obtained in normal man by electric stimulation of masseter muscle have been analyzed both in the domain of time and frequency. Data thus obtained have been compared with those obtained by the same technique in vastus lateralis and soleus muscles. Results suggest the feasibility of sound analysis in dentistry diagnosis.

Amplifiers, Electronic↗

PubMed1989

[Open evaluation of a new anti-inflammatory analgesic drug: etodolac. Report of a clinical trial].

In a controlled clinical study the efficacy and tolerance of etodolac was evaluated in patients with orthopedic or traumatologic pathology. Twenty-four patients received one 200 mg tablet of the drug in the morning and two in the evening; patients were followed for a minimum of 60 days, and laboratory tests were done at the start, mid-term and after the end of treatment. For clinical evaluation, the following parameters were assessed: --pain during movement; --morning stiffness; --pain/sleep ratio; --global evaluation. For each of these parameters, a score was attributed at the beginning and end of treatment so as to obtain a quantitative assessment of the long-term pharmacological and clinical results. The patients benefitted from the treatment with specific effects on the parameters considered. Tolerance was good: only one patient had to abandon treatment. Compliance was fair, and the results were considered satisfactory even before the planned conclusion of the trial so that patients were advised to stop taking the drug once the therapeutic objective had been achieved. Overall judgment was very good as far as the pharmacological effect was concerned, and good as to tolerance and compliance.

Adolescent↗

PubMed1984