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Biomedical subjects

R Benz

Publications and source records attributed to R Benz.

272 records · Page 16Linked to original sources

[The significance of passive smoking in pregnancy].

It is unclear whether passive smoking has any deleterious effects on pregnancy. The few investigations performed up to date seem to imply that passively inhaled cigarette smoke has teratogenic potential. To examine the extent of passive smoking during pregnancy detailed smoking histories were obtained from 442 pregnant women. Whereas only one in five women smoked actively during pregnancy, one in three women had a history of passive smoking. In additional 101 pregnant women serum-cotinine levels were determined. With this additional parameter it was possible to make a much more detailed determination of actual exposure to tobacco smoke than by using history alone.

Cotinine↗

[Blood screening for Down's syndrome in women under 35 years of age with an age-independent index].

The need for alternatives to amniocentesis, beset by 1% abortion rate, has been increasingly voiced over the past years and also includes the under 35 age group. However, the known age-dependent screening programs such as Alpha program according to Wald (1988) and the Dermalog Program according to Norgaard-Pederson (1990) only yield a detection rate of 50 or, at best, 70% (Müller, 1992) for this age group. We tried to improve this result by index calculation. Compared to the tested age-dependent screening programs the Ulm Index achieves a 25 to 40% higher detection rate (85%). For pregnant women beyond 35 years the detection rate of Down's syndrome can even be raised to 95-100% by a combination of the Alpha or Dermalog program with the Ulm Index, without entailling an increase in the rate of false-positive results.

Adult↗