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Biomedical subjects

R Benson

Publications and source records attributed to R Benson.

At least 55 records · Page 3Linked to original sources
PubMed1981

Systemic treatment of advanced prostatic cancer: development of a new system for defining response.

The low incidence of measurable or evaluable metastases in patients with prostatic cancer makes evaluation of response difficult. This is particularly true in patients with bone metastases only. With a digital model it is possible to measure quantitatively from the radioisotope bone scan the total area of skeletal involvement by metastatic tumor. Definitions of response in bone have been derived from this model. These response criteria have been compared to response in acid phosphatase determinations and clinical status in a study of 44 patients with advanced prostatic cancer treated with estramustine phosphate. Based on serial quantitative bone scans, serial measurements of acid phosphatase levels and repeat clinical evaluations a system is proposed for defining response to systemic therapy that is applicable to the majority of patients with metastatic prostatic cancer.

Acid Phosphatase↗
PubMed1980

Bladder cancer following administration of cyclophosphamide.

The relationship between cyclophosphamide and hemorrhagic cystitis is well documented; its role in inducing bladder cancer is less clear. To date, 18 cases of cyclophosphamide-associated bladder tumors have been reported. We present 3 additional cases of transitional cell bladder cancer, all preceded by hemorrhagic cystitis. Data implicating cyclophosphamide as a direct carcinogen as well as an immunosuppressive agent allowing bladder tumor development in the compromised host are discussed. While no direct relationship has been established, we suggest patients receiving this drug are at risk for developing bladder cancer, more likely transitional cell rather than squamous cell as has been reported previously.

Carcinoma, Small Cell↗
PubMed1980

Long-term survival with skin metastases from carcinoma of prostate.

Skin metastases from carcinoma of the prostate are uncommon and generally have been considered the portent of a grave prognosis. Originally, the metastatic route of this malignancy was popularly thought to be hematogenous; a lymphatic route is described in this article. We present the case of a sixty-year-old man who lived for five years after an initial diagnosis of prostatic carcinoma and for three-and-one half years after the appearance of skin metastases. We contend that skin metastases per se are not indicative of a poor prognosis, and that, as with metastases to other organs, the prognosis should be based on the histologic potential of the neoplasm as well as organ involvement elsewhere.

Carcinoma↗
PubMed1979

Preparation of reference antisera for laboratory diagnosis of blastomycosis.

Antiserum was prepared in rabbits against the A antigen and a new antigen (labeled the D antigen) of yeast-phase cells of Blastomyces dermatitidis by using immunoelectrophoretic precipitin arcs as vaccine. The antiserum can be used as a reference serum in the immunodiffusion test for identyfying antibodies to the A antigen in sera from patients thought to have blastomycosis. Antibodies to the D antigen have not yet been found in human sera. The rabbit antiserum that was absorbed with Histoplasma capsulatum yeast-phase cells did not react in the complement fixation test with either H. capsulatum yeast-phase or mycelial-phase complement fixation antigen. Therefore, it could also be used as a positive control serum in the complement fixation test. A fluorescent-antibody conjugate prepared from the absorbed serum was found to be valuable for the identification of yeast-phase cells of B. dermatitidis.

Animals↗
PubMed1978

The role of infant observation in child psychiatry training.

The authors discuss the role of infant observation in the training of child psychiatrists, emphasizing the overriding importance of the subtle but crucial interactions in the mother-infant relationship. Infant observation is valuable in preparing the student as an observer of behavior, and developmental concepts are taught and learned more easily in programs that provide opportunities for observing normal infants. The infant study program in the Department of Psychiatry of the University of Michigan Medical Center is presented as a model.

Child↗
PubMed1976

The function of a psychiatric unit in a general hospital -- a five year experience.

The author reviews his five years experience with a psychiatric unit in a general hospital. He reviews the American Literature noting such units are thought to be important. There has been no discussion of the community roles of such units. From his experience, he recommends such units play a limited but specific function in the medical and mental health delivery system.

Affective Symptoms↗
PubMed1975

Congenital malformations associated with the administration of oral anticoagulants during pregnancy.

Three small infants whose mothers had received oral anticoagulant therapy during the first trimester of pregnancy are described. These infants all had hypoplasia of the nasal bones, and two had stippling of epiphyses and bones and deformities of the bones of the hand. One child is mentally retarded. It is suggested that these abnormalities may be related to maternal oral anticoagulant therapy during the first trimester.

Abnormalities, Drug-Induced↗
PubMed1975

The forgotten treatment modality in bipolar illness: psychotherapy.

The author presents 31 bipolar patients treated with combined lithium prophylaxis and psychotherapy for up to 41 months. The grave prognosis of untreated bipolar illness is reviewed. The improved prognosis with lithium prophylaxis alone is reviewed. The author demonstrates an improved prognosis when lithium prophylaxis is combined with psychotherapy and discusses his findings as to why lithium prophylaxis alone still predicts a grave outcome.

Adult↗