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Biomedical subjects

R Bell

Publications and source records attributed to R Bell.

At least 361 records · Page 20Linked to original sources
PubMedDate not supplied

Short-latency somatosensory evoked potentials in perinatal asphyxia.

Ten asphyxiated term newborns were studied in the first 6 months of life with median nerve short-latency somatosensory evoked potentials (SLSEP) and followed subsequently to a mean age of 20 months. Results of SLSEP correlated with subsequent outcome in every patient; normal and abnormal infants at subsequent examination were separable on the basis of prior SLSEP, although the severity of later disability could not be inferred from SLSEP.

Asphyxia Neonatorum↗
PubMedDate not supplied

The use of cis-retinoic acid in recurrent respiratory papillomatosis of the larynx: a randomized pilot study.

We undertook a study of 13-cis-retinoic acid to evaluate its use as an adjuvant to laser surgery in the management of recurrent respiratory papillomatosis. In a double-blind study using placebo, four of the six subjects treated with this agent experienced recurrence while receiving therapy, with two requiring further surgical intervention. All six experienced toxicity, necessitating the withdrawal from therapy of two and dose reduction in three. When it became apparent that the therapy was ineffective, and caused toxicity, the study was closed.

Adult↗
PubMedDate not supplied

Acute administration of conjugated equine oestrogen does not improve exercise-induced myocardial ischaemia in men with coronary artery disease.

BACKGROUND: The parenteral administration of oestradiol acutely protects against exercise-induced myocardial ischaemia in women, but whether this effect is sex-specific is not known. AIMS: The effects of acutely administered conjugated equine oestrogen on exercise-induced myocardial ischaemia in men with established coronary heart disease were investigated in a randomized, placebo-controlled, double-blind cross-over trial. METHODS: Twenty men, aged 62 +/- 11.6 years, with reproducible exercise-induced myocardial ischaemia were treated with either intravenous conjugated equine oestrogen (25 mg) or saline prior to undergoing an exercise stress test. Primary end-points were total exercise time and time to 1 mm ST-segment depression. RESULTS: All participants completed the protocol. Total exercise time exceeded the baseline value in 17 of the 20 men following saline, and in 17 of the 20 men following oestrogen pretreatment. Time to 1 mm ST-segment depression exceeded the baseline value in 14 of the 19 men following saline, and following oestrogen administration, exceeded baseline in 13 of the 19 men. There was no significant difference between the two treatments in either time to 1 mm ST-segment depression or total exercise time. A period effect was apparent for total exercise time (P = 0.05) but not for time to ST-segment depression. CONCLUSION: Acute parenteral oestrogen therapy did not increase total exercise time or time to the onset of electrocardiographic changes of ischaemia in men with chronic stable coronary artery disease. These findings contrast the favourable effects of oestrogen in women in comparable studies and indicate a sex specificity for the acute cardiovascular effects of oestrogen.

Adult↗
PubMedDate not supplied

Subjective swelling: a new sign for carpal tunnel syndrome.

This single-blinded, randomized cohort study of 186 patients was conducted to determine whether the subjective complaint of swelling of the hand or wrist is associated with the diagnosis and/or prognosis of carpal tunnel syndrome. All patients were referred for splinting with a presenting clinical diagnosis of carpal tunnel syndrome from outpatient specialty clinics, including orthopedics, rheumatology, and neurology. Patients were assessed before splinting for the complaint of subjective swelling and underwent a clinical examination including Phalen testing and carpal compression testing. In addition, 211 of the 290 joints underwent electrodiagnostic testing by the end of this study. Among the 211 joints for which electrodiagnosis was used, a chi2 analysis was performed to determine the correlation among subjective swelling, the Phalen and carpal compression tests, and the electrodiagnostically verified carpal tunnel syndrome. Two weeks after splinting, an assessment was made of the subjective response to splinting. Chi2 analysis was then performed to assess the correlation among the Phalen test, carpal compression test, and nerve conduction study results and the symptom of subjective swelling at presentation with that of response to splinting. Subjective swelling of the hand showed a trend toward association with electrodiagnostic results (although this finding was not statistically significant) and proved to be significantly correlated with a poor clinical response to splinting. Positive electrodiagnostic findings were significantly, though positively, correlated with pain relief from splinting. This study, therefore, introduces the complaint of subjective swelling of the affected hand as an important diagnostic and prognostic symptom for the assessment and treatment of carpal tunnel syndrome.

Carpal Tunnel Syndrome↗
PubMedDate not supplied

Screening for ovarian cancer: is it worth the risk?

New screening methods need to be fully evaluated to assess whether they should be introduced in the NHS. This article summarises a systematic review of research on screening for ovarian cancer. There is no evidence that screening reduces the death rate and there is the potential for significant harm from diagnostic surgery in women with false positive results. Screening should be done only within well-conducted research trials.

CA-125 Antigen↗
PubMedDate not supplied

Effects of type of ownership of skilled nursing facilities on residents' mortality rates in Illinois.

The effect of ownership on the quality and cost of care in skilled nursing facilities (SNFs) was examined using unadjusted and adjusted mortality rates for such facilities in Illinois for the 1986-87 reporting year. Results indicated that when using unadjusted mortality rates, for-profit facilities had much lower rates than either government-owned or nonprofit SNFs. When mortality rates were adjusted, using available measures of intervening variables, differences by type of ownership disappeared. The higher percentage of discharges to general hospitals exhibited by for-profit facilities, compared with other types of facility ownership, appears to have the strongest effect on SNF mortality rates.

Aged↗
PubMedDate not supplied

Technical writing in the radiologic technology curriculum.

Although courses in technical writing are no longer suggested in the Curriculum Guide for Programs in Radiologic Technology, the writer believes that writing is essential to the growth of the profession and development of the professional. Emphasis is placed on some of the benefits that accrue to students who are exposed to technical writing as part of their technology curriculum.

Curriculum↗