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Biomedical subjects

R Bell

Publications and source records attributed to R Bell.

At least 307 records · Page 17Linked to original sources
PubMed1981

Biochemical and biophysical characterization of glucocorticoid receptors in normal lymphoid tissue.

3H-triamcinolone acetonide labeled glucocorticoid receptors in normal lymphoid tissues can be resolved into two component by DEAE chromatography: peak I elutes at 0.04 M salt and peak II is 0.22 M salt. By glycerol gradient centrifugation, peak I is 3.5S and peak II 8.5S. Peak I binds to DNA and chromatin, while peak II binds to neither. After heat activation, peak II alters its coefficient of sedimentation to 3.5S and on DEAE rechromatography changes its elution position to 0.04 M salt (peak I area) and acquires affinity for DNA. Glucocorticoid receptors in lymphoblastic leukemia cells can now be characterized using these techniques and compared to receptors in normal lymphoid cells.

Animals↗
PubMed1980

Chemotherapy and immunotherapy for acute myelogenous leukemia.

Eighty-six consecutive untreated adults with acute myelogenous leukemia were treated with a combination of Adriamycin, vincristine, prednisolone, Cytosine Arabinoside, and BCG. Complete remission was achieved in 39 (45%) patients; these patients were then allocated on an alternate basis to receive BCG and monthly chemotherapy with or without weekly irradiated allogeneic blast cells. The median duration of remission was eight months and was the same for both groups. The median survival of those achieving complete remission was 19 months compared with two months for those not achieving complete remission. Nine patients are still alive without relapse and five of these patients have been disease free for more than three years.

Adolescent↗
PubMed1980

Isolation, synthesis, and pharmacology of metabolites of 1-(3,4-dichlorobenzyl)-3,4,5,6-tetrahydro-2(1H)-pyrimidone.

The metabolism of 1-(3,4-dichlorobenzyl)-3,4,5,6-tetrahydro-2(1H)-pyrimidone, an antianxiety/antidepressant agent, in dogs is reported. Two metabolites, 3-[1-(3,4-dichlorobenzyl)-1-ureido]propanoic acid and 1-(3,4-dichlorobenzyl)uracil, were isolated, characterized, and synthesized. Neither metabolite was acutely toxic, and they did not exhibit antidepressant or antianxiety/anticonvulsant activity.

Animals↗
PubMed1980

Shock-induced defensive fighting in the rat: evidence for cholinergic mediation in the lateral hypothalamus.

Bilateral microinjections of scopolamine into the lateral hypothalamus significantly reduced shock-induced defensive fighting, without altering jump threshold values. Further investigation of the lateral hypothalamus demonstrated that (1) fighting increased in response to bilateral microinjections of physostigmine and carbachol, (2) social attraction remained unaltered following scopolamine treatment, (3) neither motor co-ordination nor motor activity was significantly affected by any of the treatments.

Aggression↗
PubMed1980

Rupture of pulmonary artery aneurysm associated with persistent ductus arteriosus.

Fatal haemopericardium occurred in a 14-year-old boy after rupture of a pulmonary artery aneurysm. Persistent ductus arteriosus with severe pulmonary hypertension was confirmed by cardiac catheterisation when he was 4 weeks old. Attempted closure of the ductus at 4 years had not been possible because of apparent high pulmonary resistance. Exercise tolerance had been good enough to permit competitive horse riding up to the day of death. Light and electron microsocpy showed widespread cystic medionecrosis of the elastic pulmonary arteries.

Adolescent↗
PubMed1979

Ciramadol. A new analgesic.

Ciramadol (WY 15705), a new analgesic and narcotic antagonist was studied on oral-dose form in 16 patients (15 of whom were suffering from malignant disease) to evaluate the analgesic dose and toxicity. Patients with mild or moderate pain experienced effective relief with doses of from 20 mg to 60 mg (mean dose, 47 mg). In patients with moderate to severe pain, effective pain control was not achieved (mean dose, 82 mg). There was no consistent effect on blood pressure level, heart rate, or respiratory rate. Mild or moderate sedation occurred in eight patients. Nausea and vomiting occurred in two patients.

Adult↗
PubMed1979

Kinetics and absolute bioavailability of atenolol.

Twelve healthy volunteers received four single doses of atenolol (25-, 50-, and 100-mg oral solutions and a 50-mg intravenous infusion), each dose separated by at least one week. Blood and urine assayed for atenolol by a high pressure liquid chromatography (HPLC) method. Kinetic analysis of the intravenous data indicates a three-compartment model with elimination from the central compartment. The mean (+/- SD) terminal elimination half-life is 6.06 +/- 2.02 hr, the mean volume of the central compartment is 0.173 L/kg, and 94.1 +/- 8.0% of the intravenous dose is excreted in the urine. The mean value of the plasma clearance is 10.7 +/- 1.27 L/hr and of the renal plasma clearance, 10.4 +/- 1.14 L/hr. The mean absolute bioavailability for the 25-, 50-, and 100-mg oral doses is 0.52 +/- 0.18, 0.54 +/- 0.12, and 0.58 +/- 0.16, respectively. The maximum plasma concentration varies as a linear function of dose. Time to mean maximum plasma concentration (3.0 hr) and the time for half of the bioavailable dose to be absorbed (2.0 hr) do not differ significantly with dose. The mean renal plasma clearance after oral doses (9.49 +/- 1.6 L/hr) is in the same range as renal clearance after intravenous doses.

Adult↗
PubMed1979

The effects of two "anti-aggressive" compounds, an indenopyridine and a benzothiazepin, on shock-induced defensive fighting in rats.

1. An indenopyridine (YG19-256) and a benzothiazepin (thiazesim) were investigated in rats for possible effects on shock-induced defensive fighting, shock reactivity and locomotor activity. 2. YG19-256 significantly reduced aggression at the higher dose levels employed. Thiazesim produced no significant decrease in aggression at the dose levels used. 3. Neither compound produced any consistent effect on shock reactivity or locomotor activity.

Aggression↗