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Biomedical subjects

R Baumgartner

Publications and source records attributed to R Baumgartner.

At least 145 records · Page 8Linked to original sources
PubMed1990

Clinical experience with the integral photodynamic therapy of bladder carcinoma.

Photodynamic therapy (PDT) was given to 20 patients who had recurring superficial tumours after unsuccessful application of other treatments. The phototherapeutic results were evaluated by check-ups at 3 month intervals (endoscopy, cytology, bladder mapping, renal ultrasonography) and computed tomography (CT) examination at 8-13 month intervals. In six patients treated with PDT no tumour recurrence was found over the whole observation period up to nearly 5 years. Four patients remained free of tumour (12 and 14 months) after repeated transurethral resection (TUR) and Nd:YAG laser therapy following PDT. Due to an initial application of insufficient irradiation, four patients required a second photodynamic treatment. In one of these cases a circumscribed dysplasia which appeared at the left ostium 26 months following PDT was treated successfully using the Nd:YAG laser following TUR. In six patients slight mucosal atypia persisted for a period of at least 2.5 years. One cystectomy had to be performed because of bladder shrinkage. The dissected bladder was free of tumour. According to these preliminary results, PDT with strict patient selection (worst case situation with recommended cystectomy) is justified in the case of recurrent superficial TIS bladder carcinoma.

Antineoplastic Agents↗
PubMed1990

[Determination of choroid circulatory parameters].

The equipment needed for digital image acquisition and computer-aided image analysis of ICG-choroidal angiograms is shown. The approach to image analysis, the algorithms utilized and the 2- and 3-dimensional graphic display of some of our preliminary results are briefly explained. This image analysis method allows one to summarize information from a whole image sequence into topographical 3-dimensional displays of choroidal blood flow parameters of interest.

Algorithms↗
PubMed1990

[Congenital limb abnormalities: amputate or not amputate?].

Congenital limb deficiencies pose quite a number of questions, problems and tasks that go far beyond the surgical and prosthetic-orthotic aspects present. The question of amputation in view of improved function and appearance as well as easier prosthetic provision can be answered only in the context of the orthopaedic-surgical and prosthetic possibilities available. Social, cultural and religious factors are in addition enumerated that have to be taken into account.

Amputation, Surgical↗
PubMed1990

[Photodynamic therapy of bronchial cancer].

Photodynamic therapy (PDT) with porphyrin derivatives (haematoporphyrin and dihaematoporphyrin äther/ester) and laser light of the wavelength 640 nm, is a new procedure for the treatment of carcinomas. This form of therapy is selective, can be applied through the bronchoscope, and is aimed at accomplishing curative elimination of central tumours of the lung. To date, we have successfully applied PDT in four selected patients. Our first patient was treated in April, 1987. The irradiation modalities and the clinical course are described.

Adenocarcinoma↗
PubMed1989

Long-term experience with integral photodynamic therapy of TIS bladder carcinoma.

Fifteen patients in whom superficial bladder tumours (TIS GII-III) recurred after the unsuccessful application of other treatments were treated by photodynamic therapy (PDT) and observed for 24-54 months. The results of therapy were evaluated by regular three-monthly check-ups (endoscopy, cytology, bladder mapping, renal ultrasonography) as well as by computed tomography (CT) examination at 8- to 13-month intervals. In nine patients treated by PDT no tumour recurrence has been found over the whole observation period. Two patients have remained free of tumour (12 and 14 months) after repeated transurethral resection (TUR) and Nd-YAG laser therapy after PDT. Two patients required a second application of PDT before the treatment goal was achieved. In one of these cases a circumscribed dysplasia which appeared at the left ostium 26 months after PDT was treated by TUR and Nd-YAG laser. Further observations showed it had been successfully removed. In six patients slight mucosal atypia persisted for at least 2.5 years. In the short-term course of further cases (n = 12) one cystectomy has to be performed because of bladder shrinkage. According to these preliminary results, PDT (with strict patient selection--worst-case situation with recommended cystectomy) is justified for recurrent superficial TIS bladder carcinoma.

Carcinoma in Situ↗
PubMed1989

Bronchoscopic photodynamic therapy of bronchial carcinoma.

Photodynamic therapy with photosensitizers is a new method of treating malignant tumors. In the area of bronchoscopy it is employed for the selective therapy of early carcinomas at central localizations. We report on our first attempts at treatment with hematoporphyrin derivative in an inoperable patient. The modalities of irradiation and the recurrence-free progress of, to date, 2.5 years, are described.

Bronchoscopy↗
PubMed1989

Kaposi-like acroangiodermatitis in an above-knee amputation stump.

The clinical, histological and immunohistological features of a Kaposi-like acroangiodermatitis in an above-knee amputation stump are reported. There was no evidence for an underlying arteriovenous malformation and the irregular purple-blue skin lesions resulted from chronic circulatory disturbance of the distal stump caused by a poorly fitting suction-type prosthesis.

Acrodermatitis↗
PubMed1989

[Knee exarticulation: technique for amputation of ischemic extremities].

A knee disarticulation or a trough-knee amputation stump is superior to an above-knee stump. Knee disarticulation does not require that bone be sectioned or muscle cut. The stump allows total end-load capacity. The muscle balance remains undisturbed. Due to the bulbous shape of the stump prosthetic fitting of modern appliances no longer presents problems. An operative technique especially developed for vascular patients is described in detail, including the postoperative treatment and the principles of prosthetic fitting.

Amputation, Surgical↗
PubMed1989

[Rehabilitation following amputation].

Rehabilitation after amputations is a complex interdisciplinary task which depends on numerous factors: the reason for and the level of the amputation, the quality of the stump and the limb fitting, the patient's general mental and physical state, and particularly his and his family's motivation. Strictly speaking, the normal functions can never be fully restored, even with the help of the most up-to-date techniques and rehabilitation facilities. For optimal results, full coordinated use should be made of the available methods of diagnosis and treatment. The course of rehabilitation is determined from the outset by the level of the amputation and the surgical technique. Emphasis is put on stump treatment, limb fitting, and training of the amputee, with or without a prosthetic replacement. Technical aids also are extensively used in the rehabilitation of amputees and includes various items for performing daily activities, from the workplace to the wheel chair. Even when fully equipped, a small number of amputees still remain permanently dependent on others.

Amputation, Surgical↗
PubMed1989

[Fluorescence diagnosis of porphyrin-marked urothelial tumors. Status of experimental development].

On the basis of selective storage of fluorescing hematoporphyrin derivative (HpD) in tumors, a method has been developed that enables the endoscopic detection of early-stage cancer by monitoring fluorescent images. The contrast-reducing portion of the superposed tissue autofluorescence is suppressed by the use of two-wavelength excitation and subsequent image processing in realtime. The amount of photosensitizing HpD necessary for diagnostic purposes is considerably reduced by means of sensitive detection devices. A clear distinction between benign and malignant bladder tissue seems possible according to the results of animal studies.

Animals↗
PubMed1988

Prognostic cardiac catheterization variables in survivors of acute myocardial infarction: a five year prospective study.

The prognostic variables from predischarge coronary angiography and left ventriculography in survivors of acute myocardial infarction during the years 1974 to 1978 were evaluated in 143 patients (less than or equal to 66 years of age) with documented myocardial infarction who were then followed up prospectively for 5 years. One half of the study population had triple vessel coronary disease (greater than or equal to 50% stenosis). However, only 7% of patients had severely depressed left ventricular function with an ejection fraction less than or equal to 29%. Evaluation of the contribution of many clinical and angiographic variables to a first cardiac event (death, nonfatal reinfarction or coronary artery bypass surgery) was considered with Kaplan-Meier actuarial curves and multivariate Cox's hazard function analysis. A risk segment was defined as an area of contracting myocardium supplied by a coronary artery with a greater than 50% stenosis. Multivariate analysis demonstrated that right plus left anterior descending coronary artery stenoses (p less than 0.01), ejection fraction (p less than 0.01) and the presence of risk segments (p less than 0.05) were significant predictors of outcome. Furthermore, on separate multivariate analyses, the angiographic variables added significantly to the clinical variables to predict cardiac events over 5 years of follow-up. Therefore, in survivors of acute myocardial infarction who undergo cardiac catheterization, additive prognostic information is obtained that can be used to stratify risk over 5 years.

Cardiac Catheterization↗
PubMed1988

[3 discoveries of amputations in Bern canton, Switzerland].

At La Neuveville (Switzerland) close to the Blanche Eglise a separately buried amputated leg from the 19th century was discovered. The pathological lesions of the knee joints are most likely due to a nonspecific infection (Osteomyelitis). However, postmortal defects made an exact diagnosis difficult. Two foot-amputated male burials were discovered on St. Petersinsel (Switzerland) in the monastery cemetery of the 11th to 15th century. The possible causes of these amputations are being discussed within the historical context.

Amputation, Surgical↗
PubMed1988

[Technical orthopedic management of osteopathies in adulthood].

Some indications for orthopedic appliances in the treatment of bone disease in adult patients are discussed. The fit of an appliance and comfort in use are important factors in its acceptance, as are the duration of use required and the standard of maintenance available for it. The role of orthopedic appliances in the rehabilitation of adult orthopedic patients is discussed with reference to osteogenesis imperfecta. The provision of individually adapted chair seats or extension of the patients' area of activity by means of special wheel-chairs are possible ways of improving their quality of life and, indirectly, that of their families.

Adult↗