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Biomedical subjects

R Barth

Publications and source records attributed to R Barth.

At least 109 records · Page 6Linked to original sources
PubMed1978

[Efficacy of disinfectants against rabies virus (author's transl)].

A variety of disinfectants was tested against, their efficacy against Rabies virus Flury LEP strain. The efficacy was tested by intracerebral inoculation of a mixture of virus and disinfectant into 11-15 g white mice after evaluation of the intracerebral toxic dose. Two disinfectants, based on Phenolecompound, showed a marked superior effect compared with other disinfectants. One disinfectant based on quarternary Ammoniumbase showed insufficient efficacy.

Aldehydes↗
PubMed1977

Administration of human interferon to rabies virus-infected monkeys after exposure.

The treatment of rabies-infected cynomolgus monkeys (Macaca fascicularis) with human interferon after exposure was studied. The monkeys were infected with rabies street virus by the intramuscular route; larger than or equal to 24 hr after infection, human interferon was administered intramuscularly or by lumbar spinal injection into the cerebrospinal fluid. Whereas 90% of the infected untreated monkeys died, 40%-80% of animals treated with interferon survived. No or only low levels of neutralizing antibody to rabies virus were found in the sera of monkeys that survived after a single intramuscular injection of human interferon. Distinctly higher antibody titers, however, were detected in the sera of surviving monkeys that had been given six consecutive intralumbar doses of interferon beginning three days after infections. Therefore, we conclude that in these monkeys rabies virus propagated until it spread into the central nervous system, where further viral replication was inhibited by the human interferon administered by the intralumbar route.

Animals↗
PubMed1976

[Anatomic and histologic studies of a Triatominae subfamily (Heteroptera, Reduviidae). Triatoma infestans' brain and its nerves].

To give a concrete aspect of structure, topography and function of the different nervous systems of the Triatominae, we begin this study with a description of the senso-motor system. As the first part we choose the study of the brain and its nerves. The external form of the brain is conditioned by the anatomy and morphology of the head. The brain is situated in the posterior part of the head beneath and behind the ocelli. It is characterized by the reduction of its longitudinal extension and, by this, the connectives between Syncerebrum and Gnathocerebrum are extremely short, but large, and the third commissure is included in the mass of the mandibular segment of the Gnatocerebrum. The optical masses are of the typical form, also the optical commissure. The Central Corps is volumous and is directly linked with the majority of the centres of the Protocerebrum and Deutocerebrum. The Pedunculated Corps has only one glomerulus that looks like a pedunculated mushroom without any signal of the formation of a calyx, found in ants and other more evoluted insects. Beneath the Central Corps, the extremities of the pedunculus disintegrate and form a number of claviform annexes like in the primitive Machilidae. The Deutocerebrum is characterized by volumous antennal centre, composed by numerous little glomeruli in peripheral situation. The Tritocerebrum is very reduced and has in its anterior part two very short frontal connectives and, by this, the frontal ganglion lies near the Tritocerebrum. The compact mass of the Gnathocerebrum shows its composition by three pairs of ganglions only by observation of series of preparations. With exception of the Lobi optici, 8 pair nerves and 3 impair nerves come from the brain: From the Protocerebrum: the nerves of the ocelli and the nerve of the Corpus allatum. From the Deutocerebrum: the nerves of the antennae and those of the pharynx. From the Tritocerebrum, the nerves of the labrum and, by the frontal ganglion, the Nervus recurrens and the nerve of pharyngeal muscles. From the Gnathocerebrum: the nerves of the amndibulae, maxillae, labium and of the salivary glands.

Animals↗
PubMed1975

[Sensitivity of various primate cells and animal viruses to the antiviral activity of human leukocyte interferon (author's transl)].

U cells (a permanent, human amnion cell line) were protected against infection with Semliki Forest Virus (SFV) by human interferon (HIF) from peripheral leukocytes. Despite the usual genus-specific action of interferons, mouse L929 cultures (a permanent mouse fibroblast cell line) were also protected by HIF. The antiviral action of HIF in six other primate cell cultures was also examined. It is of interest that two lymphoblastoid cell lines, RPMI1788 and Kaplan, were insensitive to HIF. The sensitivity of ten different viruses against HIF in primary African green monkey kidney cell cultures was compared. Among the viruses tested SFV was the most sensitive whereas two strains of vaccinia virus were barely inhibited. In contrast, type 1 herpes simplex virus was relatively sensitive to the action of HIF.

Amnion↗