Search PubMed⌕ Search

Biomedical subjects

R Baran

Publications and source records attributed to R Baran.

At least 199 records · Page 11Linked to original sources
PubMed1981

Nail growth direction revisited. Why do nails grow out instead of up?

In some investigations Kligman has been thought to have shown that the cul-de-sac in which the nail is formed determines that it should grow outward instead of upward. However, results obtained during the course of nail surgery for chronic paronychia and electron microscopic studies, along with genetic evidence, fail to confirm his observation on the effect of the proximal nail fold on nail growth direction. The whole subject of direction of nail growth remains questionable and worthy of further consideration.

Humans↗
PubMed1980

[Iso Kikuchi syndrome (C.O.I.F. syndrome). A report on 2 cases and a review of 44 cases in the literature (author's transl)].

Attention was drawn to congenital onychodysplasia of the index fingers (C.O.I.F.) by Iso, and later by Kikuchi who collected several cases. Micronychia, polyonychia, anonychia, hemionychrogryphosis and malalignment are the observed index finger defects. Five classical criteria were given to characterize the C.O.I.F. syndrome: 1 degree congenital, 2 degrees involvement of index fingers, 3 degrees variability in nail appearance, 4 degrees non-familial, non-hereditary, 5 degrees without bone and joint abnormalities. Alternative criteria are suggested for this syndrome. These are: 1 degree congenital, 2 degrees unilateral or bilateral index finger involvement, variability in nail appearance, 4 degrees possible hereditary involvement, 5 degrees frequent associated bone abnormalities.

Adult↗
PubMed1980

[Juvenile spring eruption (author's transl)].

Juvenile spring eruption is seen in early spring and needs a combination of different factors such as light exposure and chilling. It affects mainly boys aged 5-15 or young male adults. It involves the ears in most of the cases and may itch. The helix develops reddish papules, many of which becoming vesicular and later on crusty. Sometimes papular lesions appear on the back of the hands. The lesions heal within 2 weeks without scarring. Recurrences during following springs can be seen. Juvenile spring eruption cannot be reproduced. Histopathology study performed on 2 cases reveals a picture close to erythema mulutiforme and confirms Burckhardt's findings.

Adult↗
PubMed1979

[Bowen disease of the nail apparatus. Report of 5 cases and review of the 20 cases of the literature (author's transl)].

Five cases of Bowen disease of the nail apparatus were studied and the 20 cases published to date reviewed. The lesion was characterized by either periungual redness with scaling and erosions, whitish cuticle, hyperkeratotic or papilomatous process, fissure or crusted ulcer in the lateral nail fold or the nail bed with eventual partial or total destruction of the nail plate and sometimes soreness on the pressure. The key of the diagnosis is the histological picture, identical with that of Bowen diseases of other skin areas. Among the 25 cases, Bowen disease was found mainly in males (20 out of 25 patients) on the left fingers (17 out of 25 finger lesions) with particular involvement of the 1st, 2nd, 3rd finger nail. Hallux was concerned twice. The clinical picture can be protean and mimic verrucae, onychomycosis, paronychia, eczema, pyogenic granuloma, verrucous tuberculosis, subungual exostosis, glomus tumor, dermatitis vegetans, amelanotic malignant melanoma, kerato-acanthoma and of course squamous cell carcinoma. Treatment of choice is complete removal of the tumor by plastic surgery otherwise microscopically controlled excision following chemical fixation (Mohs) or fresh tissue technique.

Adult↗
PubMed1979

[Lichen striatus with nail involvement. Report of 4 cases and review of the 4 cases in the literature (author's transl)].

Four cases of lichen striatus (L.S.) with nail involvement were studied and the four cases published previously reviewed. There are several types of nail dystrophy: fraying, longitudinal ridging, splitting and shredding, onycholysis, and total nail loss. All of them are transient and can be explained by the pathologic changes observed, particulary the transitory disruption of the basal layer. Lichen striatus must be differentiated from systematized eruptions such as lichen planus (the simultaneous occurrence of L.S. and lichen planus is extremely rare and the resemblance of one dermatosis to the other can be so pronounced that a differential diagnosis is difficult) linear localized neurodermatitis, linear psoriasis (almost always associated with more typical lesions of psoriasis elsewhere on the body), linear keratosis follicularis (histologically typical of Darier's disease) and linear epidermal nevus which occasionaly does not appear at birth but later in life and may present nail involvement. In some cases, however, clinical similarity of the inflammatory linear verrucose epidermal nevus to lichen striatus is striking.

Adolescent↗
PubMed1978

Pigmentations of the nails (chromonychia).

Nails, particularly fingernails, may show signs that are important not only for detection of diseases of the nails themselves, but of diseases of other organs or the system as a whole. Changes of color in nail plates or nail beds sometimes seem to suggest the parts are windows to what is happening in the body. Above all, changes of color in nails that compel investigation for malignant melanoma, the most dread of diseases, are most important.

Dermatomycoses↗
PubMed1978

[Piebaldism. Clinical, pathological and ultrastructural study of three cases (author's transl)].

Comparative study of achromic and normally pigmented skin of three piebald patients from two families is reported here. DOPA-positive cells were not seen in the achromic areas, but the number of ATPase sites appeared to be normal; therefore the assumption of the replacement of the melanocytes by Langerhans cells cannot be supported. Through electron microscope, Langerhans cells looked strictly normal. Melanosomes appeared reduced in size and some alterations were noticed in their shape and contents. Ultrastructurally, a more prominent change consisted in increased undefined clear cells in the achromic skin. These dendritic suprabasal cells were devoid of melanosomes or Langerhans granules and might represent undifferentiated melanocytes. These features were discussed according to previous literature.

Adenosine Triphosphate↗
PubMed1978

[Vertical striated sand-papered twenty-nail dystrophy (author's transl)].

Vertical striated sand-papered twenty-nail dystrophy, an entity observed in both children and adults, is suggestive of an expression of alopecia areata. When the vertical striated sand-papered effect is not uniformly distributed over the full surface of the nail plates the disorder may be caused by lichen planus.

Adolescent↗