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Biomedical subjects

R Böhmer

Publications and source records attributed to R Böhmer.

At least 19 recordsLinked to original sources
PubMed1993

First isolation of Borrelia burgdorferi from an iris biopsy.

The persistence of Borrelia burgdorferi in six patients is described. Borrelia burgdorferi has been cultivated from iris biopsy, skin biopsy, and cerebrospinal fluid also after antibiotic therapy for Lyme borreliosis. Lyme Serology: IgG antibodies to B. burgdorferi were positive, IgM negative in four patients; in two patients both IgM and IgG were negative. Antibiotic therapy may abrogate the antibody response to the infection as shown by our results. Patients may have subclinical or clinical disease without diagnostic antibody titers. Persistence of B. burgdorferi cannot be excluded when the serum is negative for antibodies against it.

Adolescent↗
PubMed1992

PCR-determined expression of the MDR1 gene in chronic lymphocytic leukemia.

To determine the role the multiple drug-resistance (MDR 1) gene plays in chronic lymphocytic leukemia (CLL), we measured the expression of the MDR 1 gene in 30 patients with this disease. A rapid, highly sensitive, and nonradioactive technique based on the polymerase chain reaction (PCR) was used for that purpose. In this technique, called differential PCR, the target (MDR 1) and a reference gene (beta 2-microglobulin) are co-amplified by PCR from random hexamer-primed cDNA in the same reaction vessel. The level of target gene expression is reflected in the ratio between the intensities of the two resulting PCR product bands, as measured by high-performance liquid chromatography (HPLC). MDR 1 gene expression was detectable in 29/30 (97%) patients with CLL, with a median expression level of 0.36 U (human placenta = 1 U). There was no correlation between expression of the MDR 1 gene and clinical stage, time from diagnosis, absolute lymphocyte count, several lymphocyte surface markers, or prior treatment in the patients analyzed. Immunocytochemical studies of the same material using the monoclonal antibody C219 showed a very low or undetectable expression of the P-glycoprotein in the lymphocytes of all patients studied, whereas granulocytes were significantly more immunoreactive. We conclude that the level of expression of the MDR 1 gene in CLL is generally low, that the removal of granulocytes is important in studies of expression of MDR 1 mRNA in CLL, and that differential PCR provides a rapid and reliable method for quantifying the amount of a specific mRNA, even in very small samples of total RNA.

ATP Binding Cassette Transporter, Subfamily B, Mem↗
PubMed1985

[Histiocytosis X. Follow-up for over 20 years in a patient with Hand-Schüller-Christian disease].

Since 1963 we have observed a patient with Hand-Schüller-Christian disease with involvement of the skeleton, skin and hypophysis/hypothalamus with diabetes insipidus. The diabetes insipidus was successfully treated initially with chlorpropamid and later with carbamazepin. Alterations of the lung parenchyma were seen radiologically in 1966, and two years later the patient complained of exertional dyspnea. The lung disease was progressive with the deterioration of lung function despite corticosteroid and D-penicillamine treatment. The patient now has marked dyspnea even at rest. The osteolytic lesions have not changed in recent years.

Adult↗
PubMed1984

[Esophageal tuberculosis].

Tuberculosis of the esophagus is a rare disease, occurring in most cases secondary to tuberculosis of other organs. A hyperplastic, a granular, and an ulcerous form can be discerned macroscopically. There are neither specific clinical symptoms and signs nor typical X-ray or laboratory findings; examination of bioptic specimens also does not allow establishing a diagnosis in many cases. A case report is given of a patient with ulcerous tuberculosis of the esophagus; the clinical course and diagnostic problems are described. Diagnosis was established in this case after a secondary abscess of soft tissue had appeared.

Adult↗
PubMed1983

[Regression of an inflammatory abdominal tumor after endoscopic removal of a foreign body].

Incarcerations and perforations of foreign bodies in the gastrointestinal tract are relatively rare. In most cases the foreign bodies must be removed by operation, especially after having passed the stomach. A patient is described with an ingested chicken bone which had incarcerated in the sigmoid colon and had brought about an inflammatory stenosis of the gut. After endoscopical removement of the foreign body the symptoms of the patient disappeared and the findings in the gut returned to normal, so that an operation could be avoided.

Aged↗
PubMed1979

[Hyperuricemia].

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Diagnosis, Differential↗
PubMed1979

[Therapy of bronchitis and bronchopneumonia in adults with cefaclor (author's transl)].

Sixty-two patients with bronchopneumonia or bronchitis were treated with cefaclor. In 42 patients (= 68%), the therapy was clinically successful. Of the patients who did not respond to therapy, cefaclor-resistant bacteria were found in the sputum culture of seven. Of the remaining 13 patients, ten suffered a secondary infection with cefaclor-resistant bacteria, and in three patients the pathogen found before therapy persisted, although sensitive to cefaclor on testing. In seven patients therapy was clinically successful although cefaclor-resistant pathogens were present before the start of therapy. In the entire group of patients investigated no increase of SGOT, SGPT, alkaline phosphatase, bilirubin, urea or creatinine was observed. In two patients alkaline phosphatase and SGOT increased slightly; in three patients SGPT increased slightly. On the other hand, in several patients initially elevated SGOT, SGPT and alkaline phosphatase activity decreased during therapy. Clinical side-effects were seen in two patients. In one patient with known penicillin allergy a pruritic exanthema developed; in the other patient, who had dermatitis herpetiformis, exacerbation of skin efflorescences occurred.

Adult↗
PubMed1979

Ligation or external fistulation of the common bile duct in the rat. I. Intestinal sucrose hydrolysis and absorption in vivo.

72 h after ligation of the common bile duct in the rat the sucrose hydrolysis in vivo was greater than in sham-operated animals, whereas the absorption of the split products, glucose and fructose, was not altered. In bile-depleted rats the sucrose hydrolysis did not differ from that in the control group. The absorption of the split products, glucose and fructose, was diminished. The alterations of the sucrose assimilation were - though statistically significant - rather small. Thus, the presence of bile in the intestinal contents does not seem to be very important for the hydrolysis and absorption of sucrose in vivo.

Animals↗
PubMed1979

Ligation or external fistulation of the common bile duct in the rat. II. Intestinal disaccharidase activities.

72 h after ligation or external fistulation of the common duct the activities of maltase, sucrase and lactase in the homogenate of the small intestinal mucosa of the rat were determined. The experiments were performed in connexion with intestinal perfusion studies, and the disaccharidase activities were measured in unperfused intestinal segments as well as in intestinal loops which had previously been perfused with a sucrose-containing solution. After bile duct ligation, the sucrase and maltase activities in a previously perfused intestinal loop were not different from those in sham-operated animals, the lactase activity was diminished. In a nonperfused segment, the sucrase activity was greater, the maltase activity was unchanged, and the lactase activity was lower than in control animals. After bile duct fistulation, the sucrase, maltase and lactase activities in a perfused segment were lower than in sham-operated rats. In a nonperfused loop, the sucrase activity was greater, the maltase activity was unchanged, and the lactase activity was lower then in the corresponding control group. These data suggest that bile is a factor which influences the total mucosal disaccharidase activities, and, probably, the intracellular enzyme distribution.

Animals↗
PubMed1978

[Edema].

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Edema↗