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Biomedical subjects

R B Williams

Publications and source records attributed to R B Williams.

At least 217 records · Page 12Linked to original sources
PubMed1977

Distribution of copper and zinc in the liver of the developing sheep foetus.

1. A study has been made of the copper- and zinc-binding proteins in the livers from sheep foetuses of 80-142 d gestational age. 2. Metallothionein was found to constitute the major Zn-binding component in the cytosol at all times and to be identical to Zn-thionein from adult sheep liver. 3. Zn also occurred in two fractions, not normally found in sheep liver, with approximate molecular weights of 28000 and 47000. The relative proportions of these were age-dependent. 4. Between 15 and 35% of the hepatic Cu, corresponding to most of the Cu in the cytosol, also occurred in the metallothionein-containing fraction.

Amino Acids↗
PubMed1977

The effects of pregnancy and lactation on copper and zinc retention in the rat.

1. The accretion of copper and zinc in maternal tissues, conception products and postnatal offspring of the rat was determined at different stages of pregnancy and lactation. 2. Equations relating the weight of the bodies of the developing young and of the amounts of Cu and Zn in them to the time that has elapsed since conception showed that, early in pregnancy, the specific rates of accretion of Cu or Zn were greater than that of weight, but declined more rapidly as development continued. The instantaneous rates of accretion of both metals rose throughout pregnancy but only that of Cu continued to increase during lactation. 3. The amount of Cu in the maternal body rose significantly during pregnancy and declined thereafter, but relatively small changes in its Zn content occurred. 4. The results are discussed in relation to the relative demands for these metals during pregnancy and lactation.

Animals↗
PubMed1977

The effect of pregnancy and lactation on the absorption of zinc and lysine by the rat duodenum in situ.

1. The absorption of zinc by the duodenum of the rat was greatly enhanced at late stages of pregnancy and during lactation. 2. During pregnancy no increase in lysine uptake could be demonstrated, but during lactation, when further increases in Zn absorption occurred, uptake of lysine was increased. 3. The increased absorption of Zn at different stages of pregnancy and lactation appeared to be related to the demand made by the developing foetuses and post-natal offspring.

Animals↗
PubMed1975

Dimensional diagnosis and the medical student's grasp of psychiatry.

Two problems that interfere with the student's understanding and acceptance of psychiatric knowledge result largely from the use of a categorical model for psychiatric diagnosis. These two problems are: (1) the apparent inapplicability of the standard system of psychiatric diagnosis to real patients; and (2) the apparent irrelevance for general medical practice of psychiatric diagnosis and theory. Both problems may be avoided by presenting psychiatry in the framework of a multidimensional diagnostic schema that used familiar terms but treats them as dimensions with severe, moderate, and mild degrees of impairment rather than as categories of mutually exclusive psychiatric diseases. A teaching program is described in which detailed review of student interviews with psychiatric and especially nonpsychiatric patients is employed to demonstrate the usefulness of multidimensional psychiatric diagnosis.

Affective Symptoms↗
PubMed1975

The pharmacist's ability to use bioavailability data.

The ability of the pharmacist to use analytical, dissolution, blood level, excretion and cost data in evaluating drug products was studied. A questionnaire asked respondents to evaluate four brands of an antibiotic based on the comparative data presented. The responses of 19 pharmacists were compared to those of an expert panel. The pharmacists performed adequately in evaluating all types of data except urinary excretion data.

Biological Availability↗