When used in a dose of 100 mg/kg gutimine alpha-ketogluterate exerts a pronounced antihypoxic action in hypo- and normabaric hpoxic hypoxia ("lifting" albino mice in a pressure chamber to an "altitude" of 10000 m, rarefaction down to 198.7 mm of Hg, PO2--42 mm Hg, the chamber atmosphere containing 5.4 vol % of oxygen with the animals placed in the hermetically sealed chamber containing 5% of oxygen and 95% of nitrogen at 760 mm Hg). The absence of antihypoxic effect of the drug and exygen with the motor form of hypoxia (swimming test with the weight mass of 10 per cent of the body mass) bears evidence to the fact that the pathogenetic mechanisms in these two forms of hypoxia are dissimilar. An inference is drawn to the effect that the protective action of the drug may be associated with correction of the oxygen cycle in the organism.

Altitude↗

PubMedDate not supplied

[Radioprotective effectiveness of gas hypoxic mixture GHM-10 in experiments on dogs].

In experiments on 128 dogs (males and females) weighing 7-24 kg it was demonstrated that inhalation of gas hypoxic mixture containing O2 (10%) and N2 (90%) decreased significantly the level of PO2 in radiosensitive tissues and exerted a radioprotective effect on the exposed animals (60Co, doses of 2.8, 3.5-3.8 and 4.2 Gy, DMF = 1.3). At a dose of 8 Gy the average life of animals increased from 6.2 +/- 0.8 days (control) up to 9.3 +/- 1.1 days after the application of GHM -10.

Animals↗

PubMedDate not supplied

[Radioprotective action of a gas hypoxic mixture GHM-10 in multiple irradiations of rat and human skin].

Gas hypoxic mixture (GHM-10) decreased significantly the occurrence and duration of radioepidermitis after local therapeutic fractionated irradiation of Wistar rat skin with a cumulative dose of 66 Gy. In patients subjected to radiation therapy and protected with GHM-10 erythema and epidermitis developed at a much higher cumulative dose than in the controls. With erythema dose modifying coefficient was 1.38 +/- 0.06.

Animals↗

PubMedDate not supplied

[Modification of the intestinal syndrome using a hypoxic gas mixture under different conditions of animal irradiation].

In experiments on 1152 CBA mice and SHK colony and on 1180 Wistar rats it was demonstrated that a gas hypoxic mixture containing oxygen (10%) and nitrogen (90%) (GHM-10) reduced the intestinal syndrome of the acute radiation sickness in animals exposed to ionizing radiation at rest, during physical exercises, after radiation sickness endured earlier, after exposure to SHF, after fractionated irradiation, and after radiation-and-thermal damage.

Acute Disease↗

PubMedDate not supplied

[Comparative study in rat experiments of the radioprotective effectiveness of a gaseous hypoxic mixture and mexamine in the early postnatal period of animal development].

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5-Methoxytryptamine↗