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Biomedical subjects

R B Strelkov

Publications and source records attributed to R B Strelkov.

At least 19 recordsLinked to original sources
PubMed1979

[Radiation protection using a gaseous hypoxic mixture in oncological practice].

Studies on volunteers have shown that the gas hypoxic mixture containing 10% of oxygen and 90% of nitrogen (GHM-10) renders a protective action on the genetic apparatus of human skin cells but provides no protection of the peripheral blood leucocytes, which show the identical character of metabolic processes as neoplastic cells. Under clinically performed distant x-ray therapy for breast cancer the inhaling of GHM-10 was found to render the antiradiation protective action on different normal tissues (skin, subcellular connective tissue, muscle tissue, mammary gland tissue), but it fails to protect the tumor tissue and regional lymph nodes involved. The clinical observations were supported by pathomorphological examination of the operation material.

Adult↗
PubMed1978

[Subcellular reaction to cerebral hypoxia].

Compensatory-adaptive reaction of the brain to hypoxia depends on destructive and reparative processes developing in neuronal and glial elements. A drastic tension and reconstruction of the energy apparatus--mitochondria occurs, as well as reversible disturbances in informative connections between the nucleus and cytoplasm and between nerve fibers and synapses. As a result, structural-functional activity of organells decreases along with changes in metabolic processes. Destructive processes in oligodendroglia, at all stages of the experiment, are more pronounced than in neurons. Preliminary injection of hydroxybutyric acid to the animals preserves the cellular energy potential under hypoxia, that is evident from the lack of severe alterations in mitochondria and other organells. Mechanisms of the adaptive-compensatory reaction in cortical neurons under hypoxia are connected with tension and reconstruction of all organells of the brain cellular elements and with biochemical shifts of lactate dehydrogenase enzymes.

Adenosine Triphosphatases↗
PubMed1978

[Protective effect of sodium hydroxybutyrate and mexamine on the body and cerebral cortex neurons during hypoxia].

Experiments on white non-pure male mice have established that NA oxybutirate in doses 100 mg/kg and mexamine in doses 2.5 mg/kg possess antihypoxic properties in conditions of severe hypoxia corresponding to a height of 10 000 m. In a combined introduction of Na oxybutirate and mexamine in the above-mentioned doses there is an increase of their antihypoxic action. It was demonstrated that Na oxybutirate, mexamine and their combination exposes a distinct protective effect on the cortical neurons on rats in conditions of hypoxia. It is assumed that the protective action of the studied antihypoxants on the cortical neurons is realized with the aid of the same mechanisms as in a physiological adaptation to hypoxia.

5-Methoxytryptamine↗
PubMedDate not supplied

[Study of antihypoxic properties and toxicity of mexamine (5-methoxytryptamine)].

On its introduction to mongrel albino mice in doses of 1 to 200 mg/kg mexamine (5-methoxytryptamine) exerted a marked antihypoxic action in conditions of hypoxic hypoxia (a "rise" in the pressure chamber to an altitude of 8000 to 10 000 m) 5--180 minutes after administration of the drug. The possibility of reducing the toxicity of mexamine through preventive introduction of the agent in a dose of 1 mg/kg was established. With such a modification of the toxicity no mitigation of the antihypoxic effectiveness of the basic dose of the agent is observed.

5-Methoxytryptamine↗
PubMedDate not supplied

[Effect of intermittent normobaric hypoxic activity on the development of acute radiation disease].

The experiments on 260 male mice of colony SHK, 352 mongrel rats and 20 Wistar rats were carried out to study the ability of using the normobaric hypoxic stimulation method for acute radiation sickness. Hypoxic stimulation using gas mixture with 10% of oxygen and 90% of nitrogen was conducted for two weeks after irradiation for 30 min. every day. It is shown that under influence of ionizing radiation (7 and 5.5 Gy) the postradiation hypoxic action increased the 30-day survival rate of mice, reduced disturbances of the qualitative composition of leukocytes in peripheric blood, promoted more rapid restoration of thromboelastography indices and caused no reliable changes in the postradial content of albumin and creatinine in blood.

Acute Disease↗
PubMedDate not supplied

[Manifestation of oxygen effect during normobaric hypoxic hypoxia in the intrauterine and postnatal developmental periods].

The experiments on rats have shown that hypoxic gas mixture containing 10% of oxygen and 90% of nitrogen (HGM-10) under normobaric conditions exerts a highly reliable radioprotective effect on progeny when 11-day pregnant animals are exposed to total irradiation (60Co, 20 Gy). As distinct from the known radioprotector, mexamine, (5-methoxytryptamine), HGM-10 has a pronounced radioprotective effect during the first days (1-5) after birth. Radioresistance of new-born rats correlates with the level of pO2 in the tissues which progressively decreases with respiration of HGM-10 and remains unchanged after mexamine (10 mg/kg) introduction.

5-Methoxytryptamine↗
PubMedDate not supplied

[Influence of hypoxia on the effects of ethanol and acetaldehyde].

During experiments on male SHK mice it was established that a preliminary normobaric normocapnic hypoxic stimulation (30-minute inhalation of a gas mixture containing 10% of oxygen) increased the animal organism resistance to toxic effects of ethanol and its metabolite acetaldehyde.

Acetaldehyde↗
PubMedDate not supplied

[Modification of the radiation injury of hematopoiesis in rats using the gaseous hypoxic mixture GHM-10].

In experiments on Wistar rats it was shown that gas hypoxic mixture containing O2 (10%) and N2 (90%) had a radioprotective action with regard to the survival rate for 30 days and to the haemopoietic system status. The application of gas hypoxic mixture reduced the postirradiation cytopenia in the blood and lowered the degree of the bone marrow depletion by the 3d day following irradiation; DMF was 1.25 as determined by total bone marrow cellularity.

Animals↗
PubMedDate not supplied

[Differences in the efficacy of gutimine alpha-ketoglutarate in the hypoxic and motor forms of hypoxia].

When used in a dose of 100 mg/kg gutimine alpha-ketogluterate exerts a pronounced antihypoxic action in hypo- and normabaric hpoxic hypoxia ("lifting" albino mice in a pressure chamber to an "altitude" of 10000 m, rarefaction down to 198.7 mm of Hg, PO2--42 mm Hg, the chamber atmosphere containing 5.4 vol % of oxygen with the animals placed in the hermetically sealed chamber containing 5% of oxygen and 95% of nitrogen at 760 mm Hg). The absence of antihypoxic effect of the drug and exygen with the motor form of hypoxia (swimming test with the weight mass of 10 per cent of the body mass) bears evidence to the fact that the pathogenetic mechanisms in these two forms of hypoxia are dissimilar. An inference is drawn to the effect that the protective action of the drug may be associated with correction of the oxygen cycle in the organism.

Altitude↗