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Biomedical subjects

R B Rutherford

Publications and source records attributed to R B Rutherford.

At least 145 records · Page 8Linked to original sources
PubMed1977

The use of velocity wave form analysis in the diagnosis of carotid artery occlusive disease.

Velocity wave form analysis (VWFA) was carried out on 75 velocity tracings recorded from the common carotid artery with a continuous wave Doppler. Grouped according to clinical status, there were 20 young "normals" (I), 18 old "normals" (II), 15 stenoses of less than 50% diameter (III), 13 stenoses of greater than 50% (IV), and nine complete occlusions (V). Five of the nine dimesnions analyzed were found to be more discriminating than the others. Using these dimensions in an equation derived by discriminant analysis, the "score" of each tracing placed it into the appropriate clinical category with 95% accuracy. The accuracy rate of separating normal, stenosed, and occluded carotids was 100%. The accuracy of VWFA was limited (82%) only in discriminating between greater than and less less than 50% stenosis by diameter. Twenty-one of the 37 patients identified by VWFA as having carotid artery occlusive disease (CAOD) had normal supraorbital artery Doppler tests. Highly significant improvements in the velocity wave form of 10 carotid arteries were produced by endarterectomy.

Adult↗
PubMed1976

Platelet factors stimulate fibroblasts and smooth muscle cells quiescent in plasma serum to proliferate.

Whole blood serum is widely recognized as essential for the growth of diploid cells in culture. Dermal fibroblasts and arterial smooth muscle cells fail to proliferate in culture in the presence of serum derived from platelet-poor plasma. Platelet-poor plasma serum is capable of maintaining monkey arterial smooth muscle cells quiescent in culture at either low (1.5 x 10(3)) or high (2.0 x 10(4)) population densities. The proportion of cell traversing the cell cycle under these conditions was approximately 3%. Equal numbers of quiescent smooth muscle cells initiated DNA synthesis and cell division when treated with whole blood serum or with an equivalent quantity of platelet-poor plasma serum supplemented with a factor(s) derived from a supernate obtained after exposure of human platelets to purified thrombin in vitro.

Blood↗
PubMed1976

Comparison of hemodynamic and regional blood flow changes at equivalent stages of endotoxin and hemorrhagic shock.

Hemodynamic, respiratory, and regional blood flow measurements were carried out in two groups of monkeys at three roughly equivalent stages of endotoxin and hemorrhagic shock. Comparisons revealed characteristic differences at the two early stages, particularly in systemic vascular resistance and the pattern of distribution of cardiac output. However, at the final stage of shock, these patterns had merged and there were no characteristic differences between the two groups. The pathologic significance of these findings, in terms of the endotoxin theory of irreversible hemorrhagic shock and the realtive contributions of vasoactive humoral substances at various stages of the two forms of shock, is discussed.

Animals↗