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Biomedical subjects

R B Haynes

Publications and source records attributed to R B Haynes.

At least 127 records · Page 7Linked to original sources

How to keep up with the medical literature: II. Deciding which journals to read regularly.

For practitioners, one of the major objectives for reading the medical literature is to maintain clinical competence. Ideally, this task is accomplished through efficiently extracting from the literature properly validated advances in medical knowledge of direct relevance to the reader's own practice. Practically, the extraction process is a difficult one because reports describing such advances are disseminated through a multitude of general and specialty journals. We describe a preemptive strategy for clinicians to determine which journals to read on a regular basis. General and specialty journals of potential relevance to the reader's practice should be selected initially on the basis of circulation or citation impact, and then consecutive issues surveyed to determine the journals' yields of articles that are both directly relevant and of high quality. Subsequent reading should concentrate on the journals that produce the highest yield on this personal survey.

Clinical Competence↗

How to keep up with the medical literature: III. Expanding the number of journals you read regularly.

Clinicians can derive immense satisfaction from keeping abreast of new developments in patient care by regularly scanning the medical journal literature. Combined with good reading habits and self-discipline, this scanning generally can be accomplished within the time that most practitioners allot to attempting to keep up to date. We describe tactics for formulating a personalized journal-reading list and ensuring access to the key articles in one's field at a reasonable cost. These tactics begin with deleting low-yield journals from regular reading and adding journals more relevant to one's interests. The cost of multiple journal subscriptions can be reduced by circulating different journals among colleagues or by regular visits to the library. These tactics can be supplemented or replaced by using Current Contents or the Selective Dissemination of Information service of the National Library of Medicine and other database vendors.

Education, Medical, Continuing↗

How to keep up with the medical literature: IV. Using the literature to solve clinical problems.

Ideally, searches for published articles to solve clinical problems should lead to the best evidence on a given topic quickly and at reasonable expense. This goal can be achieved with modern information skills, sources, and services. In this article, we describe and compare various means, from textbooks to computers, that provide access to information of potential value in addressing clinical problems as they arise. Using the problem of understanding and controlling the risk for the acquired immunodeficiency syndrome among personnel of a community hospital, we examined the following sources for their utility in locating journal literature: general and specialty medical texts, personal reprint collections, expert clinicians, recent journal issues, library textbook collections, the Index Medicus "Bibliography of Reviews" and subject index, and MEDLINE computer searching. For this problem, Index Medicus and MEDLINE were the best sources of up-to-date articles, but MEDLINE was three times as fast.

Information Services↗

How to keep up with the medical literature: V. Access by personal computer to the medical literature.

Access to the medical literature through personal computers is now readily available and can greatly reduce logistical barriers to using recently published journal articles to support clinical decisions. In this article, we describe many of the options available to clinicians who wish to do their own computer searching of MEDLINE, the largest of the electronic services for the biomedical literature. The "bare bones" computer equipment needed includes a terminal or personal computer, a modern and telephone line, and a printer. Access to MEDLINE is then gained through subscribing to any of a burgeoning number of database vendors. A comparison of 17 permutations and combinations of software and vendors shows that the software and vendors vary substantially in efficiency, cost, and ease of use. Direct subscription to MEDLINE is least expensive, PaperChase is the simplest service to use, and Colleague and Medis provide both MEDLINE access plus full-text journals online. Basic search techniques are illustrated for three clinical problems.

Computers↗

How to keep up with the medical literature: VI. How to store and retrieve articles worth keeping.

The human mind is not well suited to storing and retrieving large amounts of infrequently used information. An effective personal filing system is needed if good articles that we encounter in our efforts to keep up to date are to be kept handy for future reference. Many options exist for the creation of a personal filing system. In this article, we assist the reader in the development of a tailor-made system that is based on making key decisions that strike a balance between filing needs and the lack of enthusiasm that most of us have for filing. The complexity of the system should match the number of purposes that your file must serve. Important additional considerations include how much time and effort you are willing to spend; where and how you will house your collection; how many articles you want to keep in the file; what standards you will apply in selecting material for your file; what subject headings are most appropriate for your articles; whether you will need to cross-reference; and what access you will have to personal computers.

Abstracting and Indexing↗

The measurement iterative loop: a framework for the critical appraisal of need, benefits and costs of health interventions.

A framework for organizing health services data is presented that subdivides the spectrum of health information into subgroups that constitute a logical progression from quantifying the burden of illness, through identifying its likely causes, to validating interventions that prevent or ameliorate it and evaluating their efficiency, to monitoring the application of these interventions and coming full-circle to determine whether the burden of illness has been reduced.

Cost-Benefit Analysis↗

Computer searching of the medical literature. An evaluation of MEDLINE searching systems.

Although clinicians can now search the medical literature electronically from the clinic, bedside, or operating suite, little is known about the performance characteristics of online information services. Fourteen access routes to the MEDLINE database of journal literature were compared for retrieval quantity and quality, user and online search time, and cost for randomly ordered, standardized searches on common clinical problems. All routes produced the articles we judged to be the most definitive on the clinical problem. However, routes differed significantly (p less than 0.01) for the same searches with respect to online time (range, 5.15 to 18.72 minutes), total search time (8.37 to 20.55 minutes), cost (US $3.38 to $11.62), and proportion of articles relevant to the topic (98% to 75%). "User friendliness" aside, our results showed that the higher the cost, the worse the product. Clinicians should consider these major differences when deciding which search system to use.

Costs and Cost Analysis↗

Accuracy of carotid Doppler peak frequency analysis: results determined by receiver operating characteristic curves and likelihood ratios.

To determine the accuracy of peak Doppler frequency measurements in the diagnosis of extracranial carotid arterial disease and to apply the results to the assessment of the individual patient, 397 studies of continuous-wave Doppler frequency analysis were compared with the results of arteriography. The diagnostic accuracy of the measurement of peak frequency was determined in two ways. First, receiver operator characteristic curves were calculated for different threshold levels of peak frequency. The results showed that the measurement of the peak frequency can be related in only an approximate way to the severity of the arteriographic stenosis because of the uncertainty of the probe-to-vessel angle. Nevertheless, the overall maximum diagnostic accuracy was approximately 91% (Kappa = 0.82 +/- 0.05). Second, likelihood ratios were calculated to take into account the degree of abnormality of the peak frequency measurements. The probability of carotid disease increased as the peak frequency increased, giving likelihood ratio ranges from 0.03 to 25.71. To be able to apply the peak frequency measurements to the assessment of the individual patient in the vascular laboratory, our results were used to construct tables that show the posttest probability of carotid disease based on the clinically estimated pretest probability of disease and the measured peak frequency. It is concluded that the measurement of peak Doppler frequency is an adjunct in the diagnosis of carotid artery disease.

Aged↗

Educational package on hypertension for primary care physicians.

The usefulness of an educational package on hypertension that provides clinically important, up-to-date medical information and office "aids" to primary care physicians was tested in a randomized controlled trial. Fifty-six physicians completed a pretest multiple-choice questionnaire and were allocated at random either to a group that received the educational package (the "study group") or to a control group. There was a highly significant correlation between the pretest scores and the number of years since graduation (r = -0.55, p less than 0.0001), which indicated that younger physicians are more likely than older physicians to have an up-to-date knowledge of the management of hypertension. The increase in knowledge in the study group (17.5%) was significantly greater than that in the control group (2.7%). Furthermore, although the post-test scores in the control group were still significantly correlated with the number of years since graduation, those in the study group were not. It was concluded that although the older physicians knew less than their younger colleagues about hypertension, the use of the educational package significantly increased knowledge, and the increase was not limited by the physician's age.

Age Factors↗

A critical appraisal of the efficacy of continuing medical education.

To determine the efficacy of continuing medical education (CME), we collected 248 original articles describing studies of CME interventions. These articles were reviewed for applicability and scientific credibility by applying preset methodological criteria. Thirteen percent of articles described randomized trials, but only 7% of all articles and 20% of randomized trials assessed the impact of CME on patient outcomes. Seven articles met all our criteria and were reviewed in detail. These studies provide convincing evidence that CME can improve physician behaviors. However, only three of these methodologically sound studies assessed patient outcomes and only one demonstrated any improvement in outcomes.

Certification↗

A critical review of compliance studies in rheumatoid arthritis.

Nineteen studies of treatment compliance in rheumatoid arthritis (RA) patients have been critically appraised to assess the magnitude and determinants of noncompliance in this population. Deficiencies in study methodology undermined the possibility of firm conclusions on the influence of various factors on compliance in RA populations. Nevertheless, it is apparent that noncompliance with treatments for RA is a major problem that hitherto has not been widely considered. Compliance with prescribed drug regimens varied from 16% to 84% among these studies. With physiotherapy regimens, compliance rates varied from 39% to 65%, while for splint-usage, rates varied from 25% to 65%. No consistent correlation has been demonstrated between compliance and age, sex, treatment side effects, disease severity, or drug dose frequency. Gaps in our present day knowledge have been detailed and the need for further research is outlined.

Arthritis, Rheumatoid↗

Effects of labelling on income, work and social function among hypertensive employees.

Two hundred and thirty hypertensive Canadian steelworkers were followed for 5 years after screening and referral. Data on income, absenteeism and measures of work and social function were collected on these men and on a matched group of 230 normotensive employees. In the fifth year after screening, hypertensive employees earned an average of Can. $1093 less than normotensive employees despite similar incomes in the year before screening. This adverse effect on income was observed regardless of awareness of hypertension at the time of screening or compliance with treatment. Illness-related absenteeism among hypertensives rose in the year following screening and remained elevated for 4 years after screening. Normotensive and hypertensive employees reported similar levels of physical ability and psychological well-being. These findings need verification in other settings before inclusion in cost-effectiveness analyses of the management of hypertension.

Absenteeism↗

Labelling in hypertension: a review of the behavioural and psychological consequences.

Recent evidence has suggested that the detection and treatment of hypertension can result in adverse psychological and behavioural consequences. Furthermore, there is evidence to suggest that these consequences may outweigh the gains in the case of mild hypertension where the benefit of treatment has not yet been established. This paper reviews the literature to date regarding the behavioural and psychological changes which have occurred upon the detection and labelling of hypertension. In addition, an explanation is posed which may resolve some of the contradictory findings with regard to the phenomenon. Finally, a strategy to alleviate, or at least minimize, the deleterious labelling of individuals as "hypertensive" is proposed for testing in future experiments.

Absenteeism↗

Failure of weight reduction to reduce mildly elevated blood pressure: a randomized trial.

To determine the value of weight reduction on blood pressure, we randomly allocated 60 untreated, mildly hypertensive, obese individuals to a no-treatment control group or to a behaviourly-oriented weight loss ('diet') programme administered by professional dietitians. Behavioural techniques included self-monitoring, shaping, reinforcement and modelling. Subjects were reassessed after six months by an observer who was unaware of their study group. Fifty-four subjects (90%) completed the study. Diet subjects lost 4.1 kg and controls only 0.8 kg (P = 0.018). However, neither systolic nor diastolic blood pressures differed. The chance that we missed a clinically important diastolic difference of 6 mmHg (our pre-study target) is less than 1%. We conclude that our weight loss programme was successful in reducing weight but that weight loss is not useful in lowering blood pressure in mild, otherwise untreated hypertensives.

Blood Pressure↗