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Biomedical subjects

R B Hawkins

Publications and source records attributed to R B Hawkins.

22 records · Page 2Linked to original sources
PubMed1975

Infection after silicone prosthetic arthroplasty in the hand.

After 2105 silicone prosthetic arthroplasties in the hands of 631 patients, infections occurred in ten. The average time from operation to onset of signs and symptoms of infection was seventeen days, and in seven of the ten patients the infecting organism was Staphylococcus aureus. Seven patients ultimately were treated by removal of the prosthesis, intravenous antibiotics for about five days, and oral antibiotics for about two weeks. At follow-up, twelve to fifty-six months after operation, nearly all of the patients had stable, somewhat stiff but pain-free joints, the results being similar to those after resection arthroplasty.

Adult↗
PubMed1971

The physical measurement of radiation damage to coliphage T7 DNA.

Coliphage T7 was exposed to (60)Co gamma radiation while suspended in phosphate buffer or in phosphate buffer plus 0.001 M l-histidine. DNA was isolated from the phage by incubation with pronase, followed by extraction with cold phenol. The intrinsic viscosity of the DNA was measured as a function of radiation dose. The fraction of DNA molecules surviving radiation treatment with no double-strand breaks was measured from the radiation-induced heterogeneity of the DNA sedimentation boundary. From comparison of these measurements it is concluded that radiation introduces lesions other than double-strand breaks which affect the hydrodynamic properties of the DNA. In both buffer and buffer plus histidine the surviving fraction of intact virus genomes far exceeds the surviving fraction of plaque-forming units at any given dose. It was found that the decrease in intrinsic viscosity with dose is independent of the presence of histidine in the radiation medium. From this it is concluded that DNA damage is primarily due to a direct effect of radiation on the phage particle. The procedure necessary to isolate DNA from irradiated virus suggests that radiation produces covalent bonding of protein to the DNA.

Cobalt Isotopes↗