Search PubMed⌕ Search

Biomedical subjects

R B Goldstein

Publications and source records attributed to R B Goldstein.

117 records · Page 7Linked to original sources
PubMed1980

Perinatal developmental changes in hepatic UDP-glucuronyltransferase.

Postnatal developmental changes in hapatic microsomal UDP-glucuronyltransferase were studied in the rat. The previously reported postnatal decline in the capacity of microsomal fractions to glucuronidate p-nitrophenol was found to be observable in unperturbed preparations only at non-saturating concentrations of the substrate UDP-glucuronic acid. At saturating concentrations of UDP-glucuronic acid, activity is identical in newborns and adults. Kinetic analysis revealed that the enzyme from liver of newborns has a much higher affinity for UDP-glucuronic acid than does the enzyme in adults, but the same activity at Vmax. On the other hand, the enzyme from adult liver microsomal fractions can be activated by the physiological allosteric effector UDP-N-acetylglucosamine, whereas the enzyme from newborns is largely unaffected by it. Thus it appears that the number of enzyme active sites is not changing; rather, the enzyme is maturing to a more highly regulable form. There were also differences between the enzymes in newborns and adults in their response to perturbation of the membrane-lipid environment by detergent and phospholipase A. Possible interpretations of these differences are discussed.

Aging↗
PubMed1975

Sodium urate accelerates precipitation of calcium oxalate in vitro.

Precipitation of calcium oxalate crystals from a metastable solution can be detected within 10 min if crystalline sodium urate is added at a solid to liquid ratio of 0.1 mM or more. Without urate, precipitation begins after 50 min. Uric acid is not effective. Pyrophosphate inhibits the effects of sodium urate.

Calcium↗
PubMedDate not supplied

Sonography of anencephaly: pitfalls in early diagnosis.

A case in which the diagnosis of anencephaly was missed on a standard obstetrical sonogram performed at 12.5 menstrual weeks is described. Prompted by this case, we retrospectively reviewed the appearance of the cephalic pole of normal fetuses in 47 pregnancies ranging in menstrual age from 11 weeks to 16 weeks. Results indicate that the abnormal cephalic pole in the index case was similar to the appearance of many normal fetuses of similar menstrual age. We conclude that while anencephaly may be diagnosed as early as 11 menstrual weeks to 12 menstrual weeks, this defect may be difficult to diagnose on sonograms using standard sonographic techniques prior to 14 menstrual weeks.

Anencephaly↗
PubMedDate not supplied

Compulsive behaviors and obsessive-compulsive disorder (OCD): lack of a relationship between OCD, eating disorders, and gambling.

The lifetime prevalence of eating disorders and pathologic gambling was assessed in first-degree relatives of subjects with obsessive-compulsive disorder (OCD) and well controls. There were no significant differences between the groups. The authors conclude that eating disorder and pathologic gambling have no familial relationship to OCD.

Adolescent↗
PubMedDate not supplied

Measures of distress in 26 "environmentally ill" subjects.

The authors report on measures of distress in 26 subjects who had been diagnosed with environmental illness (EI) by a "clinical ecologist." EI subjects were more likely than control subjects to meet criteria for one or more personality disorder diagnoses assessed with the Structured Interview for DSM-III Personality Disorders and exhibited more somatic, mood, and anxiety symptoms assessed with the Symptom Checklist-90-R and the Illness Behavior Questionnaire. The authors conclude that subjects receiving this diagnosis may suffer from unrecognized psychological distress, which may account for some or all of the symptoms that had resulted in a diagnosis of EI.

Adult↗
PubMedDate not supplied

An electronic menstrual cycle calendar: comparison of data quality with a paper version.

OBJECTIVES: This pilot study compared a prototype electronic menstrual calendar on a handheld computer with a paper calendar for data quality and participants' perceptions. DESIGN: Twenty-three women completed identical information about menstrual bleeding and symptoms using paper and electronic calendars for 1 month each. RESULTS: Use of the paper calendar resulted in more missing data than the electronic calendar for bleeding characteristics (13% vs. 4%) and symptoms (35% vs. 4%). The electronic calendar's ability to log data entries revealed retrospective entry for 61% of the data. Total data entry and cleaning time was reduced by 81% with the electronic calendar. Overall, participants preferred the electronic (70%) to the paper (22%) calendar. CONCLUSIONS: Data quality with conventional paper calendars may be poorer than recognized. The data-logging feature, unique to the electronic calendar, is critical for assessing data quality. Electronic menstrual calendars can be useful data collection tools for research in women's health.

Computers↗