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Biomedical subjects

R B Friedman

Publications and source records attributed to R B Friedman.

At least 55 records · Page 3Linked to original sources

Computerized tomographic and magnetic resonance imaging of intracranial lipoma. Case report.

Intracranial lipoma is an uncommon lesion that has been well described in both the neurosurgical and neuroradiological literature for many years. This lesion is usually only an incidental finding, but it may be symptomatic. The authors describe a case of symptomatic intracranial lipoma of the superior medullary velum with emphasis on the correlation between computerized tomography and magnetic resonance imaging in evaluation of the lesion.

Brain Neoplasms↗

Left hemisphere pathways in reading: inferences from pure alexia without hemianopia.

In pure alexia, reading is impaired despite almost normal speech, spelling, and writing. We studied a right-handed man with pure alexia, but no hemianopia. He had more difficulty reading longer words (word-length effect), but had no selective reading impairment in phonologic or semantic analysis. Clinical-CT correlation suggests that (1) left hemisphere visual pathways crucial for reading arise from or pass close to the left occipitotemporal or inferior temporal gyrus, and (2) relevant transcallosal fibers from the right hemisphere course inferior to the posterior horn of the left lateral ventricle before ascending to left hemisphere language areas.

Aged↗

Impact of the evolution in health care delivery on the academic medical center.

The academic medical center is currently being affected by major changes in the national health care delivery system. These changes include the rapid growth in prepaid health plans, the emerging surplus of physicians, and the continued escalation of health care costs. The potential effects of these changes are only now becoming appreciated and may have significant ramifications for the entire medical education system. In this article, the author traces the impact of these changes on one major academic medical center. He presents a methodology for pinpointing other centers that may soon be affected and discusses ways to minimize the undesirable consequences of these changes.

Academic Medical Centers↗

Interactive video.

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Microcomputers↗

Prognostic factors in invasive gallbladder carcinoma.

The medical records of 52 patients from the University of Wisconsin Hospital and Clinics with carcinoma of the gallbladder were examined retrospectively. The cases were reviewed for factors in their medical history, presenting physical examination, laboratory data, therapy, pathological grade, and histology that might effect median survival. Only a prior complaint of anorexia, an elevated lactic dehydrogenase (LDH), or advanced pathologic stage at time of diagnosis provided significant prognostic information. Combining pathologic stage and histologic grade additively provided the most significant prognostic information [1]. Division of gallbladder carcinoma patients in future clinical trials by this combined (stage and grade) stratification scheme may prove helpful in assessing the efficacy of new therapies. The knowledge that anorexia and elevated LDH are poor prognostic findings may assist physicians in counseling patients with this malignancy.

Aged↗

Experience with an automated cancer protocol surveillance system.

At an active cancer center, patients may be on a large number of different treatment protocols. Each of these protocols has its own examination, test, and treatment modification requirements. It is often difficult for the clinician to keep track of the protocol requirements on all of his patients, so elements of the protocol may be inadvertently omitted. To assist the physician in managing these patients, a computerized protocol surveillance system was developed and implemented at a major cancer center. Compliance with protocol requirements was studied prior to and after introduction of the automated protocol system. There was a statistically significant (p less than 0.02) improvement in nonroutine test ordering (from 80 to 95%) and therapeutic modification (from 91 to 99%) compliance. Introduction of an automated protocol surveillance system can result in improved protocol compliance.

Cancer Care Facilities↗

Mechanisms of reading and spelling in a case of alexia without agraphia.

In the clinical syndrome of alexia without agraphia, reading is greatly disturbed while writing and spelling remain relatively intact. The most commonly accepted explanation of this pattern of findings is that the center for written language interpretation remains intact, but has become inaccessible to visual input. This paper examines the nature of the intact written language center with respect to specific mechanisms of reading and spelling in a patient presenting with the major components of alexia without agraphia. It is concluded that the dissociation between reading and writing performance found in this patient reflects the existence of separate and distinct mechanisms for reading and spelling.

Adult↗

On the underlying causes of semantic paralexias in a patient with deep dyslexia.

The nature of the underlying causes of paralexias produced by a patient exhibiting the syndrome of deep dyslexia was explored by pairing an oral reading task with a picture matching task using the same words. The results suggested two causes of semantic paralexias: word retrieval difficulties and impaired concept arousal. Parallel deficits in language tasks not involving written words were found. It is suggested that the major component of the deep dyslexia syndrome may reflect a deficit which is not specific to the written modality.

Anomia↗