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R B Couch

Publications and source records attributed to R B Couch.

159 records · Page 9Linked to original sources
PubMedDate not supplied

Reactogenicity, immunogenicity, and antibody persistence in adults given inactivated influenza virus vaccines - 1978.

Monovalent A/USSR/77 (H1N1) and trivalent A/USSR/77, A/Texas/77 (H3N2), and B/Hong Kong/72 influenza virus vaccines from four manufacturers were tested in 292 adult volunteers. Systemic reactions were mild and resembled those with 1976 (swine) vaccines containing similar doses (in micrograms) of viral hemagglutinin. Trivalent vaccines caused more local inflammation than did monovalent, especially in older women. Two doses containing 7 micrograms of hemagglutinin each were required to induce a titer of hemagglutinin-inhibiting antibody of greater than or equal to 40 against A/USSR/77 virus in a majority of persons with an initial titer of less than 10, but one dose containing 20 micrograms of hemagglutinin did so; even one dose containing 7 micrograms was sufficient if the initial titer was greater than or equal to 10. Vaccine-induced titers of antibody to A/USSR/77 virus fell more during the six months after vaccination in younger than in older adults; this observation suggested that prior experience with related influenza viruses alters both production and persistence of antibody after vaccination. Seroconversions to A/Texas/77 and B/Hong Kong/72 viruses were more frequent in younger than in older adults with titers less than or equal to 20 before vaccination, but the final proportion of volunteers with titers of greater than or equal to 40 was high in both groups. Standardization of dosages in terms of micrograms of hemagglutinin appeared to reduce differences in responses to vaccines of different types and sources.

Adult↗
PubMedDate not supplied

[Role of Mycoplasma pneumoniae in the etiology of acute respiratory infections in Ribeirao Preto, Sao Paulo, Brazil].

Mycoplasma pneumoniae isolation was attempted in respiratory fluids from 64 patients with respiratory infection Complement fixation test (CF) and counterimmunoelectrophoresis (CIE) were used for Mycoplasma antibody detection using the patient sera. Mycoplasma pneumoniae was not isolated. Serologic diagnosis were positives in 3.1% (2/64) by CF test and 1.6% (1/64) by CIE. Serologic tests done in 200 health controls showed 4% (8/200) positives by CIE and 1% (2/200) by CF. The results showed differences in sensitivity among the serologic tests. CF seems to be more indicated for Mycoplasma infection diagnosis while, CIE could be used for Mycoplasmas serosurveys. The prevalence of Mycoplasma pneumoniae infections was low (3.1%) in the 64 patients during our study period.

Acute Disease↗
PubMedDate not supplied

[Combined action of remantadine (amantadine) and ribavirin on experimental influenza].

The inhibiting effect of remantadine (amantadine) and ribavirin combination on experimental influenza infection was studied in comparison of the effect of each of these drugs alone. The combination of the two chemopreparations was found to inhibit synthesis of influenza A virus proteins in cell culture more effectively, to ensure maximum survival rate of white mice treated with these preparations by oral, aerosol and intraperitoneal routes of administration.

Administration, Oral↗