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Biomedical subjects

R B Clark

Publications and source records attributed to R B Clark.

270 records · Page 15Linked to original sources
PubMed1967

Guest editor.

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Anesthesia, Obstetrical↗
PubMed1967

"Saddle block".

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Anesthesia, Spinal↗
PubMedDate not supplied

In vitro susceptibilities of Edwardsiella tarda to 22 antibiotics and antibiotic-beta-lactamase-inhibitor agents.

The in vitro susceptibilities of 22 isolates of Edwardsiella tarda were studied with 22 antibiotics and antibiotic-beta-lactamase-inhibitor agents. Results indicated that all isolates were susceptible to the aminoglycosides, cephalosporins, penicillins, imipenem, aztreonam, ciprofloxacin, and antibiotic-beta-lactamase-inhibitor agents. Each strain produced a beta-lactamase even though no resistance was detected to the beta-lactams.

Animals↗
PubMedDate not supplied

Aortic stenosis, cesarean delivery, and epidural anesthesia.

A 23-year-old female was referred to the University of Arkansas for Medical Sciences at 32 weeks' gestation with a history of aortic stenosis following aortic valve replacement. Evaluation by echocardiography showed an approximately 90 mmHg transvalvular pressure gradient. Pregnancy progressed to 36 weeks' gestation without problem, at which time the patient underwent cesarean section with lumbar epidural anesthesia. Invasive hemodynamic monitors were used to assess cardiac performance and as a guide for anesthetic management. The impact of aortic stenosis on pregnancy is discussed, as are management aspects of lumbar epidural anesthesia in such patients.

Adult↗
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An Apgar timer.

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Biomedical Engineering↗
PubMedDate not supplied

Mathematical model of an adult human atrial cell: the role of K+ currents in repolarization.

We have developed a mathematical model of the human atria myocyte based on averaged voltage-clamp data recorded from isolated single myocytes. Our model consists of a Hodgkin-Huxley-type equivalent circuit for the sarcolemma, coupled with a fluid compartment model, which accounts for changes in ionic concentrations in the cytoplasm as well as in the sarcoplasmic reticulum. This formulation can reconstruct action potential data that are representative of recordings from a majority of human atrial cells in our laboratory and therefore provides a biophysically based account of the underlying ionic currents. This work is based in part on a previous model of the rabbit atrial myocyte published by our group and was motivated by differences in some of the repolarizing currents between human and rabbit atrium. We have therefore given particular attention to the sustained outward K+ current (I[sus]), which putatively has a prominent role in determining the duration of the human atrial action potential. Our results demonstrate that the action potential shape during the peak and plateau phases is determined primarily by transient outward K+ current, I(sus) and L-type Ca2+ current (I[Ca,L]) and that the role of I(sus) in the human atrial action potential can be modulated by the baseline sizes of I(Ca,L), I(sus) and the rapid delayed rectifier K+ current. As a result, our simulations suggest that the functional role of I(sus) can depend on the physiological/disease state of the cell.

Action Potentials↗
PubMedDate not supplied

Physostigmine reversal of sedation in parturients.

Parturients in whom meperidine HCl, propiomazine HCl, and scopolamine were used for analgesia and amnesia in labor and delivery were studied to determine the efficacy and safety of physostigmine reversal after delivery. Of a total of 120 patients, 108 received physostigmine salicylate at the completion of episiotomy closure, awakening in an average of 7.5 minutes compared with 137.8 in 12 controls. Physostigmine appears to be a safe, rapidly effective agent for reversing the prolonged somnolence of this sedation regimen.

Adult↗