Synovial fluid acid phosphatase in rheumatoid arthritis.
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Acid Phosphatase↗
Biomedical subjects
R B Clague
Publications and source records attributed to R B Clague.
Enhancement (by native type II collagen) of the humoral immune response to native type I collagen in the rat.
Both native type II collagen and rabbit IgG were good immunogens in the rat when emulsified in incomplete Freund's adjuvant but native type I collagen and denatured type II collagen were not. Both native type II collagen and rabbit IgG had an enhancing effect upon the production of antibodies to native type I collagen when rats were immunised with a mixture of native type I collagen and either of these immunogens but denatured type II collagen did not have this effect. These immunogens, however, did not enhance the production of antibodies to ovalbumin when emulsified with it. Although both native type II collagen and rabbit IgG showed this enhancing effect with native type I collagen, only rats immunised with native type II collagen or mixtures containing native type II collagen developed arthritis. Thus, a specific immune response to collagen rather than this enhancing effect appears to be necessary for the induction of arthritis.
Animals↗
Native type II collagen-induced arthritis in the rat. II. Relationship between the humoral immune response to native type II collagen and arthritis.
The onset of arthritis in Sprague-Dawley rats occurred between 10-13 days after intradermal injection of collagen when serum IgM and IgG antibody levels to native type II collagen had reached high levels. Although arthritis could be induced in rats immunized with 25-500 microgram native type II collagen in incomplete Freund's adjuvant, higher serum IgM and IgG antibody levels to native type II collagen occurred in arthritic rather than non-arthritic rats irrespective of the immunizing dose of collagen. Studies in 3 different rat strains showed that higher serum antibody levels to native type II collagen were found in the strain with the highest incidence of arthritis. All these findings suggest that these antibodies are one essential for the induction and/or perpetuation of native type II collagen-induced arthritis.
Animals↗