Experimental observations on the behaviour of nerve grafts in sheaths formed around silicone rods.
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Biomedical subjects
Publications and source records attributed to R B Berry.
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The frequency of non-clostridial anaerobic infection was studied in 95 patients who had undergone acute appendicectomy: 49 received prophylactic metronidazole and 46 received placebo. Anaerobic infection did not develop in any of the metronidazole-treated patients, but infections did develop in nine (19%) of the 46 controls. Metronidazole is conveniently administered by suppository to patients who cannot take oral drugs. Five patients with intra-abdominal infections caused by non-clostridial anaerobes were successfully treated with metronidazole.
A single 27 gauge implant of PGE2 into the periventricular region of the hypothalamus resulted in a significant increase in sexual receptivity in estrogen primed, ovariectomized female rats. Open field activity levels were only slightly decreased while rectal body temperature increased significantly over control values. It is postulated that the effects upon sexual receptivity might be mediated by PGE2 stimulated LRF release.
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We evaluated the effects of inhomogeneous lung emptying on the relationship of partial to maximal complete expiratory flow by obtaining pre- and post-metaproterenol maximal (MEFV) and partial flow-volume curves in normal subjects and asthmatics. Partial curves were initiated between 65-70% of vital capacity after inspiration from functional residual capacity (PEFV curve) or after deflation from total lung capacity (PEFVDI curve). Since PEFVDI curves were initiated at lower lung volumes than MEFV manoeuvres (but with a similar volume history), non-homogeneous emptying should cause higher flow on PEFVDI than on MEFV manoeuvres. Expiratory flow (Vmax) was highest on MEFV manoeuvres in normals and PEFV curves in asthmatics. Pre- and post-metaproterenol Vmax was very similar on MEFV and PEFVDI manoeuvres in both groups, although Vmax(MEFV) slightly but significantly exceeded Vmax(PEFVDI) in normals and the reverse was true in asthmatics. Lung elastic recoil did not differ significantly on MEFV and PEFVDI manoeuvres in either group. We conclude that asthmatics demonstrate inhomogeneous emptying. However, because flow-volume curves are relatively insensitive to sequences of lung emptying, inhomogeneous emptying during forced expiration only has minor effects on the relationship of partial to maximal expiratory flow.