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Biomedical subjects

R B Alfin-Slater

Publications and source records attributed to R B Alfin-Slater.

10 recordsLinked to original sources
PubMed1978

Effect of administration of alpha- and gamma-tocopherol on tissue distribution and red cell hemolysis in rats.

Four groups of rats fed a tocopherol-free diet from weaning were administered, orally, 1.5 mg/day of either alpha- or gamma-tocopherol for 12 weeks or 5 mg/day of these compounds for 6 weeks. The fifth group was continued on the tocopherol-free diet. At the end of the experimental period the concentration of the two tocopherols was measured in plasma, RBC, liver, kidney, heart, spleen, muscle, testes and lungs. At the lower dose levels alpha-tocopherol, but not gamma-tocopherol, protected the RBC from hemolysis. At the higher levels both compounds were effective in this respect. While liver and spleen appeared to be the preferred storage tissues for both alpha- and gamma-tocopherols, a considerable amount of these compounds were found in RBC, muscle, heart and lung. The content of alpha-tocopherol in the liver was significantly greater than that of gamma-tocopherol. Whether this difference is the reflection of preferential utilization of gamma-tocopherol remains to be determined. The other tissues showed a more or less equal accumulation of the two compounds. At the higher levels of supplementation with the tocopherols the accumulation of gamma-tocopherol in most tissues was significantly greater than that of alpha-tocopherol.

Animals↗
PubMed1977

Vitamins.

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Animals↗
PubMed1976

An evaluation in rats of nutritional status and reproduction performance post oral contraceptive therapy.

Adult female rats were orally administered either 0.052, 0.26 mg of Enovoid E (OC) or the vehicle, propylene glycol. Thereafter they were mated six, thirteen or twenty-seven days after the discontinuation of the drug. Chemical analyses i.e. cholesterol levels in plasma, liver and adrenals; tocopherol levels in plasma and liver; fatty acid patterns of cholesteryl esters of plasma liver, and adrenals, and plasma lipoproteins distribution, were performed on the pre-breeding (post-OC) females, mothers (following weaning of the young) and young female progeny, 10 weeks after weaning. Weanlings derived from mothers previously exposed to OC weighed more than their counterparts from mothers who had not been given the drug. A slight decrease of the survival time of the young during lactation was also observed in groups treated with higher levels of OC. Liver weights were increased in mothers as a result of pregnancy and lactation. Observed elevations of plasma cholesterol levels and cholesteryl arachidonate in the livers of the progeny were probably due to prolonged exposure to the 15% corn oil diet. In addition, previously reported metabolic effects of OC, such as increases in liver cholesteryl oleate, decreases in plasma and adrenal cholesteryl arachidonate, decreases in the alpha/beta lipoprotein ratio and alpha-tocopherol levels in plasma were confirmed.

Adrenal Glands↗