Immunization-induced changes in later intra-abdominal abscess formation are mediated by cellular and humoral mechanisms.
Explore the source record for details and available documents.
Abscess↗
Biomedical subjects
R B Adams
Publications and source records attributed to R B Adams.
Development of Candida albicans and C. albicans/Escherichia coli/Bacteroides fragilis intraperitoneal abscess models with demonstration of fungus-induced bacterial translocation.
The development of models of both Candida albicans and mixed C. albicans/Escherichia coli/Bacillus fragilis peritonitis in immunologically normal mice are described, each with significant mortality and intra-abdominal abscess formation. C. albicans inoculated alone induced bacterial translocation into abscesses, and the addition of bacteria reduced the number of, but did not eliminate. C. albicans in abscesses. There was no synergy seen between fungi and bacteria in terms of either morbidity or mortality.
Abdominal Abscess↗
Effectiveness of fluconazole in murine Candida albicans and bacterial C. albicans peritonitis and abscess formation.
The role of fluconazole in the treatment of many forms of focal mycoses remains unclear. We studied the effectiveness of three different oral doses of fluconazole in three murine models of Candida albicans peritonitis leading to intra-abdominal abscess formation. During monomicrobial Candida infection, fluconazole decreased mortality and the number of C. albicans cultured per abscess; prolonged treatment also eliminated Escherichia coli translocation. In mixed C. albicans/E. coli/Bacteroides fragilis infection, prolonged treatment with higher doses of fluconazole decreased mortality, the number of abscesses formed, and the number C. albicans per abscess. In animals with a similar polymicrobial infection but with concurrent cefoxitin treatment, fluconazole decreased mortality and the number of C. albicans per abscess; in addition, prolonged treatment reduced the number of abscesses. Amphotericin B gave similar results in all three models. These data indicate that the clinical use of fluconazole in peritonitis should be investigated.
Abdominal Abscess↗
A miniature segment-length strain gauge arch for the assessment of myocardial function.
A miniature myocardial segment-length strain gauge arch utilizing solid-state strain gauge elements is described. The arch weighs 0.25 g, has a frequency response flat to 30 Hz, requires simple circuitry, and is stable in situ for periods exceeding 6 hours. Its miniaturization and ease of insertion offer distinct advantages over similar devices previously described. Miniature arches have been applied simultaneously to multiple sites to assess left ventricular function in dogs. The response of these arches to a variety of interventions indicates that this device may be used to follow localized segment-length and velocity changes. The study also clearly demonstrates that the orientation of strain gauge arches with respect to muscle fiber direction in the ventricular wall qualitatively and quantitatively affects the recorded segment-length alterations.
Animals↗