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Biomedical subjects

R Arndt

Publications and source records attributed to R Arndt.

At least 55 records · Page 3Linked to original sources
PubMed1991

[Microbiologic findings in protracted and chronic enterocolitis].

Novel diagnostic methods (immunoblotting, immunofluorescence test) have been proved to be very sensitive and specific for detecting enteropathogenic bacilli. 28 patients with chronic enterocolitis were investigated. In 50% (14/28) of these patients Yersinia enterocolitica could be visualized in biopsies by immunofluorescence. The serum of 8 patients also contained IgA-antibodies against plasmid encoded released proteins of Y. enterocolitica. This paper reports evidence for persistence of Yersinia bacilli in a group of patients with chronic enterocolitis. Further studies must show, if these results may have therapeutic implications.

Adolescent↗
PubMed1991

[Clinical results of filling intraoral bone defects with ionomeric porous microimplants (V-Os)].

In a clinical trial over a period of two years 50 cavities were filled up with an ionomeric porous micro implant (V-Os)* as bone replacement material after apicectomy and excision of cysts. Primary healing was found in 43 cases. 3 months after the operation 44 of 46 examined cases showed no pathological signs. In two cases the material had to be removed. 2 years after the operation 35 cases should be examined, in one case there was a fistula, the other cases showed no pathological signs. The comparison of the individual reproducible X-ray pictures after 3, 6, 12 and 24 months shows a bone regeneration next to the implanted micro implant.

Alveolar Bone Loss↗
PubMed1990

[Recommendations for the diagnosis and therapy of meningitis, Waterhouse-Friderichsen syndrome and encephalitis in childhood].

Representatives of the working group of "Neuropaediatrics" and "Infectology" like to present recommendations on diagnostics and treatment of infectious diseases on the CNS. Individual opinions can not be considered in recommendations always. Therefore we have to understand these recommendations in this way that individual decisions will not be restricted in special situations.

Child↗
PubMed1990

[BCG osteomyelitis and arthritis].

Since 1980 an increase of the frequency of osteomyelitis after BCG vaccination has been described by some european countries. In the GDR osseous impairments as BCG complication are rarely. The authors report on an 18 months old boy with lesions of the distal tibia and the ankle-joint. He was vaccinated with BCG in the neonatal period. In contrast to the local findings general symptoms were unimportant. The surgical treatment was completed by antituberculotic chemotherapy. This treatment was successful.

Ankle Joint↗
PubMed1990

[A contribution to the frequency and assessment possibilities of chronic aspecific respiratory tract diseases (CARD)--an epidemiological study in the mostly agricultural district of Neubrandenburg].

A test was carried out in order to determine representative information on CNSRD prevalence in children at the age of 3 to 15 and to check possibilities of registration. A clinical examination was performed at a totality of 122,400 children of a district, a sample test of 2,927 children was carried out. 10% of the children suffer from chronic diseases of the respiratory tract. In 3 to 4% of these children it is required to apply an acute or frequent therapy. The incidence of asthma bronchiale totals 1 to 2%.

Adolescent↗
PubMed1989

[Impairment of the immune system by HIV infection].

CD4 + T-helper lymphocytes are the main target cells in HIV infection. Since CD4 molecules are not restricted to T-cells but also found on monocytes, macrophages, follicular dendritic cells, Langerhans cells, and microglial brain cells, these cells might be affected, too, by HIV. HIV binds via the gp 120 envelope protein to the 67 KD CD4 membrane protein. Patients with HIV infection show distinct autoimmunological reactions against the cells of their immune system. Autoantibodies directed against CD4 cells seem to be responsible for the extent of the immune deficiency and are, therefore, of prognostic value. Aside from CD4+ cell depletion, the functional impairment of the T-cell system plays an important part in the progress of the disease. Patients with depressed gamma-interferon production after stimulation with antigens are at a risk for AIDS-related opportunistic infections. Polyclonal production of immunoglobulins and impaired stimulation of B-cells are characteristic for B-cell dysfunction. NK-cell dysfunction depends on reduced production of IL-2 and altered gamma-interferon production of T-cells infected with HIV.

Acquired Immunodeficiency Syndrome↗
PubMed1989

Renal transplantation using cyclosporine with and without regard to HLA matching: a randomized prospective unicenter study.

A randomized prospective unicenter study produced no significant difference in 2-year outcome between the use of well matched cadaver renal allografts shared among transplantation centers, and the use of organs of local origin matched only for blood group. Graft and patient survival rates, transplant function and incidence of rejection were compared. On the basis of 1 and 2-year outcome with well matched and shared allografts we conclude that cyclosporine therapy makes HLA matching unnecessary.

Adolescent↗
PubMed1989

[Immunomodulation by cryosurgery in malignant melanoma].

Cryosurgery is a well-known, established method for the local destruction of tumor tissue by freezing. The assumption that, in addition to a physical and blood vascular phase, an immunological phase exists, has been discussed by many authors and tested using animal models. These results can only be transferred to humans in a limited sense. During the last year, we initiated a randomized study "Cryosurgery versus Conventional Surgery", whereby the peripheral blood and the normal skin from the areas surrounding the resection were compared. We were able to demonstrate in the peripheral blood of 8 cryosurgery patients a postoperative increase in the total and helper T-cells, HLA-DR-positive cells, and the ratio helper/suppressor T-cells in comparison to preoperative values. In the 8 patients treated with conventional surgery, these parameters decreased slightly or remained the same. The differences were highly significant (p = 0.001) to significant (p = 0.01). The results from the first 16 are patients studied presented and discussed here.

Adult↗