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Biomedical subjects

R Allen

Publications and source records attributed to R Allen.

At least 271 records · Page 15Linked to original sources

Sex differences in mental health.

The purpose of this study was to investigate the relationship between sex and mental illness. A sample of male and female adult psychiatric outpatients (n = 44) completed the Denver Community Mental Health Questionnaire (DCMHQ), the Taylor Manifest Anxiety Scale, an abbreviated version of the Minnesota Multiphasic Personality Inventory (the Mini-Mult), and the Social Readjustment Rating Scale. Differences in life event experiences, as well as differences on measures of anxiety, depression, psychological distress, and social functioning, were explored and identified by means of Pearson product-moment correlations. The strongest correlations were found between sex and four of the subscales of the DCMHQ: women tended to be less productive and evidenced more psychological distress than men; men had more legal difficulties and were more likely to use soft drugs. A modest correlation was found on the Taylor Manifest Anxiety Scale, with women showing higher scores.

Adult↗

Permselectivity of cat blood-lymph barrier to endogenous macromolecules.

The restrictive properties of liver blood-lymph barrier to endogenous plasma protein fractions of varying molecular size were studied at different hepatic venous pressures (and lymph flows) using steady-state lymph to plasma protein concentration ratios. At control hepatic venous pressures (0-2 mmHg) the lymph to plasma venous concentration ratios of the various protein fractions indicate significant selectivity by the liver blood-lymph barrier to macromolecules on the basis of molecular size. The sieving observed was consistent with equivalent pore radii of 180-250 A. The transsinusoidal oncotic pressure gradient ranged between 4.0 and 8.0 mmHg at control venous pressures. As venous pressure was increased, liver lymph flow and lymph to plasma protein concentration ratio increased while the blood-lymph oncotic pressure gradient decreased. Liver lymph flow was linearly related to hepatic venous pressure. At lymph flow less than or equal to 10 x control, there is no longer a sieving effect on plasma protein; findings consistent with por radii in excess of 1000 A. The results of this study suggest that maximal sieving by the liver blood-lymph barrier occur at normal capillary filtration rates and support the possibility that the interstitium is the rate limiting barrier for blood to lymph transport of macromolecules in the liver.

Animals↗

Use of ephedrine to control anal urinary incontinence.

A case illustrating the use of ephedrine to control urinary incontinence from the rectum is reported. It is postulated that this successful treatment is due to the action of ephedrine on the smooth muscle of the anal sphincter.

Anal Canal↗

Primary urethral malignancy: review of 22 cases.

Twenty-two cases of primary urethral malignancy have been diagnosed at the Medical University Hospital from 1955 to 1976. These lesions are uncommon and prognosis is poor except when disease is diagnosed in the early stages and treated aggressively. Anterior lesions are more often diagnosed at an early stage but may be mistaken for benign processes, delaying appropriate therapy. Our experience with urethral malignancies is reviewed and includes an association of carcinoma with urethral caruncles and diverticula. The first reported association of a urethral diverticulum with carcinoma in the male is presented and two additional cases of adenocarcinoma in female urethral diverticula are reported. Excision of urethral caruncles and diverticula is encouraged.

Aged↗

Host function-dependent induction of defective interfering particles of vesicular stomatitis virus.

Suppression of host cell function by treatment with actinomycin D prior to infection prevented the induction of defective interfering particles of vesicular stomatitis virus, which had been cloned and propagated in cell pretreated with actinomycin D. Replication of defective interfering particles already present in an infecting virus stock, however, was not affected by pretreatment of cells with actinomycin D. Thus, the induction, but not the replication, of defective interfering particles appears to be a host cell function-dependent phenomenon. The implications of this phenomenon for host defense mechanisms against virus infections are discussed.

Cell Line↗

Space allocation decisions in schools of allied health.

Growth is continuing in schools of allied health in terms of faculty, enrollments, the use of university-based clinics and in the volume of training facilities required for allied health education. At the same time, budgets for future expansion of facilities are likely to become more stringent. Thus, the efficient allocation of physical space within schools of allied health is extremely important and it will become more important in future years. This paper examines procedures for evaluating space needs in allied health schools. A number of possible approaches, and their strengths and weaknesses, are explored. Influences of the physical environment--of which space is a primary component--on behavior is considered in the context of allied health education and their implications for space allocation are explored. The likely effects of Occupational Safety and Health Administration (OSHA) regulations on space utilization are also examined. Throughout the analysis recommendations are made for the safe and effective use of the available physical space within which allied health education occurs.

Facility Design and Construction↗

Social dysfunction and anxiety.

A sample of 44 male and female adults, newly admitted to outpatient clinics at a large community mental health center, was given the Denver Community Mental HEALTH Questionnaire on social functioning, the abbreviated version of the Minnesota Multiphasic Personality Inventory, the Social Readjustment Rating Scale, and the Taylor Manifest Anxiety Scale. The results indicate that impairment of social functioning, as well as personality disturbance and excessive change, is strongly associated with anxiety. The outcome implies that effective treatment must include social and vocational training in addition to psychotherapy.

Adult↗

The fate of the untreated alcoholic. Toward a natural history of the disorder.

Eighty-three male alcoholics were administered a structured interview when they appeared at a large general hospital for treatment of a variety of disorders. These represent 83 consecutive cases. None received treatment aside from brief "drying-out" but all were accepted as participants in a research program. Seventy-three (88 per cent of the sample) were located for a 3-year follow-up; five of these were not seen at the 1-year follow-up, and 10 were known to be dead. This paper focuses on 58 of the alcoholics who were seen at all three evaluations, and the 10 who were known dead. The data are presented as indicating the long term results of, at best, a mild or minimal intervention with male alcoholics. A small, but significant improvement was noted on several life-adjustment scales between the initial and 1-year evaluation (OYE), but no further improvement was seen between OYE and the 3-year evaluation (TYE); 19 percent were abstinent for 1 year and 10 per cent for the full 3-year period. The best predictor of TYE abstinence was OYE abstinence, but only for the extremes, i.e., no abstinence or total abstinence. Abstinence success was also related to a tendency to use community resources, lower number of mental hospitalizations, higher occupational status, higher global rating and, curiously, lower interpersonal adjustment rating. The group using Alcoholics Anonymous showed no better outcome than the group using no community resources at all. The mortality rate was 12 per cent over the 3 years or slightly more than 4 per cent a year. The suicide rate was about 4 per cent over the 3 years. The ratings for those dying showed a pattern of more admitted drunken arrests and heavy recent drinking superimposed on lighter overall drinking for the past year. The study demonstrates that even untreated alcoholics can be traced and effective follow-up studies completed. Results also indicate that over long time periods and left to their own devices, many alcoholics do seek out some form of help. But such assistance tends not to be sustained or intensive and a good portion of it is nonprofessional and nonmedical. Moreover, a surprisingly substantial number (31 per cent) of hospital-identified alcoholics apparently neither seek out nor receive any help at all after their initial identification; yet their self-reported life-adjustment ratings do not differ significantly from those who do seek help. The no-help receivers may be the most critical group of all to follow, as they are trule untreated. It would be important to determine how consistent in fact they are in their avoidance of help, what accounts for that behavior, and whether their ultimate fate is different from those who regularly seek assistance.

Alcohol Drinking↗

Simple procedure for the removal of nonspecific inhibitors of rubella virus hemagglutination.

The adsorption of serum lipoproteins onto an insoluble matrix of colloidal silicic acid results in the removal of nonspecific inhibitors of rubella virus hemagglutinin. The procedure can be performed in 15 min at room temperature. Comparative studies using both the dextran sulfate-CaCl2 and heparin-MnCl2 methods for removal of inhibitors demonstrated that the colloidal silicic acid procedure yielded identical hemagglutination inhibition titers. In addition, it is technically feasible to read titers below 1:8.

Adsorption↗