Biomedical subjects

R Adar

Publications and source records attributed to R Adar.

255 records · Page 15Linked to original sources

PubMedDate not supplied

Perigraft lipid accumulation with unusual complications in a hyperlipidemic patient.

A 50-year-old man with hyperlipidemia, on long-term clofibrate therapy, 2 g/day, developed a series of unusual complications after insertion of a Dacron bifurcation graft from the aorta to the right popliteal and left femoral arteries. There were false aneurysms at all graft-to-artery suture lines, and a clinical picture of peripheral cholesterol emboli developed. At operation, a lipid accumulation under pressure was found between the graft and the perigraft adventitia. The perigraft adventitia later ruptured and a psoas muscle xanthomatous inflammatory mass developed, causing an acute abdomen; a second operation was performed. The mechanism of formation of the perigraft lipid accumulation and the relationship of this unusual sequence of complications to the hyperlipidemia or its treatment with clofibrate are discussed.

Aorta↗

PubMedDate not supplied

Initial experience with mesocaval H grafts: comparison with other portosystemic shunts.

Two policies concerning portosystemic shunt for bleeding esophageal varices were compared. In 18 patients, splenorenal or portocaval shunts were performed according to anatomic and hematologic considerations. In 13 patients, only mesocaval H grafts were performed. In the latter group, more patients had poor liver reserve and required urgent surgery. Accordingly, early and late mortality and morbidity were higher in these patients. the technical ease of performance of the mesocaval H graft did not cancel out increased risk in poorer candidates for surgery.

Adult↗

PubMedDate not supplied

Determination of the pressure drop across an arterial stenosis utilizing angiocinedensitometry.

A method is presented for an evaluation of the hemodynamic significance of a stenotic lesion in the arterial tree.Twenty-three patients were examined with arteriosclerosis obliterans and intermittent claudication of the same severity. Flow velocity data obtained by angiodensitometry and viscosity values calculated from the hematocrit were inserted into the Poiseuille's flow formula to obtain the pressure drop across a stenotic lesion in the left external iliac artery. By the same way, the pressure gradient was calculated in 33 "normal" subjects.The normal pressure gradient along the external iliac artery varied between 23 to 110 dynes/cm(2) (52 ± 24 dynes/cm(2) for mean and S.d), and the normal resistance to flow was 6.08 ± 4.1 dyne sec/cm(5)).Stenotic lesions of similar dimensions gave widely varying pressure drops (114-4,736 dynes/cm(2)) (mean and S.d 1,309 ± 1,224 dynes/cm(2)) indicating a difference in the hemodynamic significance of the various lesions. These values were significantly different (p(t) < 0.001) from the normal values. The resistance across these stenotic lesions ranged between 21 to 768 dyne sec/cm(5) (196 ± 192 dyne sec/cm(5)) for the mean and S.d and this was significantly different from the normal group; p(t) < 0.001.Direct measurement of blood viscosity coupled with angiocinedensitometry at rest and after forced vasodilatation should provide an accurate means of determining the relative significance of a stenotic lesion and distal vessel disease in a given patient on blood flow to the leg.

Arteriosclerosis Obliterans↗