[Dagnosis and treatment of sarcoma botryoides (author's transl)].
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Biomedical subjects
Publications and source records attributed to R Ackermann.
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Two children of mothers who, in the second half of pregnancy, had been in touch with golden hamsters, had an internal hydrocephalus at birth and extensive chorio-retinitic scars in both eyes. One newborn also had myopia magna, the other severe bilirubinaemia. Increasing titres of neutralizing serum antibodies in both mothers and children and falling titres of complement-binding serum antibodies against the virus of lymphocytic chorio-meningitis argue for a causative role of this micro-organism, apparently transmitted by the hamsters.
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Serum from 39 of 288 (13.5%) cancer patients contained antibodies detectable by immunofluorescence which reacted with frozen tumour sections from kidneys, prostate glands and ovaries. The serum did not react against areas of normal kidney taken from the same diseased organ. In comparison, 0.7% of normal persons and 3.8% of patients with non-malignant diseases had antibody activity. Sections from two colon carcinomas did not react with the serum. It is concluded that tumour-associated antibodies do not necessarily have histological type specificity and are worthy of further study.
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