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R Abbate

Publications and source records attributed to R Abbate.

201 records · Page 12Linked to original sources
PubMedDate not supplied

Increased thrombin generation in normal pregnancy.

The aim of this longitudinal study was to evaluate whether an increased thrombin generation takes place in normal pregnancy by determining fibronopeptide A plasma concentration in 24 women at three stages of gestation. The activity of the main blood clotting inhibitors, antithrombin III and protein C., and platelet agregability were also investigated. Our study showed a significant rise of fibrinopeptide A plasma levels already manifest at the first trimester. Antithrombin III activity was found to slightly but significantly decrease during pregnancy, whereas protein C levels showed a moderate, significant increase. A slight platelet activation was observed in the second and third trimester. These findings indicate that during pregnancy a new equilibrium of blood clotting system arises, shifted to a hypercoagulable state which leads to the increased risk of thromboembolism observed in pregnancy.

Adult↗
PubMedDate not supplied

[Hormone replacement therapy and cardiovascular pathology in menopause].

Although the incidence of vascular disease increases progressively with age, the increment observed in women between 50 and 60 years old does not seem to be directly correlated to the menopause. On the other hand, significant modifications of some risk factors, particularly those related to lipid metabolism and the hemostatic system have been observed in postmenopausal women. It should be stressed that the results of these studies, although generally concordant, cannot be applied directly to the entire population: the majority of women studied were well-educated and from the upper-middle social and economic classes and thus more prone to comply with behavioral and therapeutic precepts. Moreover, non-white women were excluded from these studies. At present, numerous data attest to the beneficial effect of hormone replacement therapy on cardiovascular disease in postmenopausal women. The presently running National Institutes of Health 9-year randomized primary prevention study (Women's Health Initiative) and the secondary prevention "Heart Estrogen/Progestin Replacement Study" should, within a few years, provide further and, it is hoped, definitive information concerning the utility of hormone replacement therapy for the primary and secondary prevention of cardiovascular disease.

Aged↗